MSc Neuroscience at the Institute of Psychiatry
King's College London

Basic chemistry tutorial
A1.1 Neuroanatomy and neuropathology
A1.1.1 Introduction to brain structure/anatomy
A1.1.2 Research Methods I
A1.1.3 Research Methods II
A1.1.4 Biology of neurons
A1.1.5 Microglia and oligodendrocytes
A1.1.6 Astrocytes
A1.1.7 Introduction to neuropathology
A1.1.8 An overview of cerebral connectivity
A1.2 Cell biology
A1.2.1 Amino acids and proteins 1
A1.2.2 Amino acids and proteins 2
A1.2.3 Molecular biology
A1.2.4 Molecular biology methods
Molecular Biology and Genetics Tutorial Group A
Molecular Biology and Genetics Tutorial Group B
Amino Acids and Protein Tutorial Group A
Amino Acids and Protein Tutorial Group B
A1.2.5 Growth, differentiation and death
A1.2.6 Concepts in cell biology
A1.2.7 Gene expression
A1.2.8 Apoptosis
A1.3 Neurotransmission
A1.3.1 Receptor isolation, purification and binding assays
A1.3.2 Receptor occupancy theory
A1.3.3 Membrane, synaptic and action potentials
A1.3.4 Use of cloning and expression systems to investigate ionotropic receptors
A1.3.5 Use of cloning and expression systems to investigate metabotropic receptors
A1.3.6 Structure and function of voltage and ligand-gated channels
A1.3.7 Techniques for monitoring neurotransmitters in vivo
A1.3.8 Pharmacology of glutamate and excitotoxicity
A1.4 Cell signalling
A1.4.1 Receptor-effector coupling: G proteins,adenylate cyclase and phosphatidylinositol
A1.4.2 Receptors and transcriptional regulation
A1.4.3 Cell-cell signalling 1
A1.4.4 Cell signalling 2
A1.4.5 Control of gene expression
A1.4.6 Neurotrophic factors

A2.1 Neurogenetics
A2.1.1 Linkage and association
A2.1.2 Genetics of complex disorders
A2.1.3 Genomics
A2.1.4 Bioinformatics
A2.2 Developmental neurobiology
AA2.2.1 Basic Principles of neural development
A2.2.2 Patterning the brain
A2.2.3 Neurogenesis and migration
A2.2.4 Axon guidance
A2.2.5 Synapse formation
A2.2.6 Circuit formation
A2.2.7 Neurodevelopmental disorders
A2.3 Neuronal plasticity
A2.3.1 Cortical map plasticity
A2.3.2 Long term potentiation
A2.3.3 Molecular manipulations to understand hippocampal function
A2.3.4 Neural Networks - I
A2.3.5 Neural Networks - II
A2.3.6 Neural Networks - III
A2.3.7 Neural Networks - IV
A2.4 Neuroimmunology
A2.4.1 Immune reactions in the CNS
A2.4.2 Antigen and molecular movement
A2.4.3 Cell migration into the CNS
A2.4.4 Antigen presentation
A2.4.5 Microglia
A2.4.6 Cytokines and cell activation
A2.4.7 Neuroimmunology; from basic immunology to disease treatment

A3.1 Systems neuroscience
A3.1.1 Pain and pain systems
A3.1.2 Hypothalamic pituitary axis - basic functioning
A3.1.3 Hypothalamic pituitary axis - clinical relevance
A3.1.4 Cognitive processing in cortico-striatal circuits
A3.1.5 Vision - part 1
A3.1.6 Vision - part 2
A3.1.7 Motor control
A3.2 Addiction biology
A3.2.1 Genetics of substance abuse
A3.2.2 Molecular biology of drug addiction
A3.2.3 Animal models and neurocircuitry of addiction
A3.2.4 Pharmacological and reinforcing effects of drugs in humans
A3.2.5 Concurrent addictive and psychiatric disorders
A3.3 Neuropsychology of mental health
A3.3.1 Clinical aspects of psychoses
A3.3.2 Neurobiology of psychoses
A3.3.3 Clinical aspects of affective disorders
A3.3.4 Neurobiology of affective disorders
A3.3.5 Neurological disorders
A3.3.6 Dementia
A3.3.7 Neural substrates or normal and abnormal development
A3.3.8 Learning and memory in humans
A3.3.9 Animal models of psychiatric disease
A3.4 Neuroimaging
A3.4.1 Introduction to neuroimaging
A3.4.2 Basic principles of functional imaging
A3.4.3 Molecular and cellular MRI
A3.4.4 Brain hodology 1
A3.4.5 Brain hodology 2
A3.5 Neurodegeneration
A3.5.1 Molecular pathology of Alzheimer's disease
A3.5.2 Parkinson’s disease and related disorders
A3.5.3 Amyotropic lateral sclerosis and other motor neuron disorders
A3.5.4 Prion disorders
A3.5.5 Polyglutamine repeat disorders
A3.5.6 Neurodegenerative diseases of childhood

Neurodegeneration
B.1 Parkinson's disease
B.2 Huntington's disease
B.3 Gene therapy for neurodegenerative disease
B.4 Clinical trials relevant to neurodegenerative disease
B.5 Autophagy in Neurodegeneration
B.6 The epidemiology of dementia
Genetics
B.7 Gene - environment interactions
B.8 Epigenetics
B.9 Genetics of Alzheimer's disease and related dementias
B.10 Genetics of schizophrenia and bipolar disorder
Developmental Neurobiology
B.11 Neural induction
B.12 Axon pathfinding and disease modelling in Drosophila
B.13 Influencing the fate of embryonic neural progenitor cells
B.14 Stem cells and brain repair
B.15 Epigenetic regulation of neural development and neuropsychiatric disorders
Neuroimmunology
B.16 Clinical Neuroimmunology
B.17 Virus diseases of the CNS
B.18 Bacterial and parasitic infections of the nervous system
DTI and Tractography
B.19 Networks underlying language and praxis
B.20 Aphasias and apraxias
B.21 Projection pathways (interactive virtual dissections)
Neuroimaging
B.22 Imaging techniques in drug addiction
B.23 Neuroimaging in schizophrenia
B.24 Neuroimaging in dementia
B.25 Neuroimaging in depression and bipolar disorder
Addiction Biology
B.26 Receptor pharmacology of major addictive drugs
B.27 Acute effects, sensitization and conditioned drug effects
B.28 TBA
B.29 TBA

B1.1 An introduction to the genetics of normal and abnormal behaviour
B1.2 The human genome
B1.3 A case study of gene-hunting in depression
B1.4 Analysis of genetic association studies
B1.5 Quantitative genetics and the twin model
B1.6 The discordant MZ twins design as a method for investigating environmental influences
B1.7 Quantitative and molecular genetic studies of ADHD
B1.8 Cognitive impairment in ADHD
B1.9 Genes, environment and translation in ADHD
B1.10 Genes and cognitive abilities and disabilities
B1.11 The origins of cross-cultural differences in cognitive abilities
B1.12 Interface between cognitive and behavioural genetic research on autism
B1.13 What has behavioural genetic research taught us about autism?
B1.14 Chromosomal abnormalities and autism spectrum disorder
B1.15 Genetic factors in the development and treatment of anxiety and depression
B1.16 Cognitive biases in fear and anxiety: genetic origins and mechanisms
B1.17 The genetics of schizophrenia
B1.18 Genetically informative studies of psychopathic traits
B1.19 Gene - environment interactions
B1.20 The nature and nurture of psychological wellbeing
B1.21 Genetic and environmental risk factors for unipolar and bipolar affective disorders
B1.22 Gene x environment interactions in drug addiction
B1.23 Cellular and molecular psychiatry
B1.24 Epigenetics: mediating the interplay between nature and nurture
B1.25 Genomic imprinting
B1.26 Epigenetics in drug addiction
B1.27 Tutorial: Analysing behavioural genetics research papers I
B1.28 Tutorial: Analysing behavioural genetics research papers II
B1.29 Tutorial: Written exam preparation
B1.30 Dry Lab Practical: Basic statistical genetics training
B1.31 Wet Lab Practical: Basic molecular lab training

B2.1 Drug use and addiction in humans – introduction
B2.2 Measuring drug addiction related behaviours in humans
B2.3 The effects of drug addiction on mental illness
B2.4 Clinical trials in addiction treatment
B2.5 Biomarkers of addiction in humans
B2.6 Morphological and functional effects of chronic drug use in the brain
B2.7 Neuroanatomy of the reinforcement system of the brain
B2.8 Imaging techniques in drug addiction
B2.9 Acute and chronic cellular effects of drugs
B2.10 Withdrawal, relapse and reinstatement
B2.11 The effects of addictive drugs on brain activity
B2.12 Receptor pharmacology of major addictive drugs
B2.13 Acute effects, sensitization and conditioned drug effects
B2.14 Reinforcing effects and self-administration
B2.15 Drugs of abuse and cognitive effects
B2.16 Genetic methods in addiction research
B2.17 B2.17 The genetic base of drug addiction
B2.18 B2.18 Genetic imaging in drug addiction
B2.19 B2.19 Gene x environment interactions in drug addiction
B2.20 Translational approaches in addiction: from preclinical to clinical treatment
B2.21 MicroRNA and drug addiction
B2.22 Tutorial: Analysing addiction neuroscience research papers
B2.23 Epigenetics in drug addiction
B2.24 Prenatal effects of addictive drugs
B2.25 Drug effects during adolescence vs. adulthood
B2.26 Analysing addiction neuroscience research papers II
B2.27 Tutorial: Written exam preparation
Training classes on basic molecular lab techiques

Introduction and welcome
B3.1 Neural induction
B3.2 Tutorial: Model organisms in developmental neurobiology research
B3.3 Asymmetric division in the vertebrate neural tube
B3.4 Patterning the spinal cord
B3.5 Patterning the forebrain
B3.6 Patterning subregions of the Drosophila brain
B3.7 Development of cranial sensory ganglia
B3.8 Cerebellum; neurogenesis, migration and circuit building
B3.9 Coordinating neural development with non neural tissues
B3.10 Axon guidance of motorneurons
B3.11 Tutorial: Bioinformatic approaches to neural development
B3.12 The growth cone and cytoskeletal regulation
B3.13 Axon pathfinding and disease modelling in Drosophila
Lab Tour at MRC Centre for Developmental Neurobiology
B3.14 Neurodevelopmental implications of PI3 kinase signaling
B3.15 Tutorial: Writing an abstract Part I
B3.16 FGF signalling and neurodevelopmental disease
B3.17 Dendritic remodelling
B3.18 Neuroendocrine systems and aging in C. elegans
B3.19 Tutorial: The axon initial segment: Neural excitability and polarity
B3.20 Role of activity during synapse formation in the visual system
B3.21 Homeostatic plasticity during development
B3.22 Visual circuitry
B3.23 Tutorial: Writing an abstract Part II
B3.24 Retinotectal development
B3.25 Stem cells and brain repair
B3.26 Tutorial: Use of functional genomics in neural development
B3.27 Building functional circuits
B3.28 Stuctural plasticity in the cortex
B3.29 Influencing the fate of embryonic neural progenitor cells
B3.30 Transcriptional regulation of neural development and neurological disease
Tour of the CCBB Laboratories at the James Black Centre: contact Brenda Williams and Angela Bithell
B3.31 Epigenetic regulation of neural development and neuropsychiatric disorders
B3.32 Tutorial: Adult neural stem cells
B3.33 Post-transcriptional gene regulation of stem cell development
B3.34 Course de-briefing and question and answer session

B4.1 Introduction to the module
B4.2 Paediatric storage disorders
B4.3 Neuroprotection in Parkinson's disease
B4.4 Clinical aspects of amyotrophic lateral sclerosis
B4.5 Multiple sclerosis
B4.6 The epidemiology of Alzheimer's disease and other dementias
B4.7 Huntington's disease
B4.8 Prion diosrders
B4.9 Genetics of Alzheimer’s disease and related dementias
B4.10 Processing of amyloid precursor protein in Alzheimer’s disease B4.11 Genetics of Parkinson's disease
B4.12 The role of the cytoskeleton in neurodegeneration
B4.13 Genetics of complex neurodegenerative disorders
B4.14 Defects in axonal transport in neurodegenerative disease
B4.15 Imaging in neurodegeneration
B4.16 Mitochondria and neuronal energy balance
B4.17 Phosphorylation mechanisms implicated in neurodegeneration
B4.18 Impaired RNA processing
B4.19 Pathways to protein degradation
B4.20 Synaptic dysfunction in Alzheimer's disease
B4.21 Aberrant signalling in Alzheimer's disease
B4.22 Transcriptional dysregulation in neurodegeneration
B4.23 Drosophila as a model of neurodegenerative disease
B4.24 Neuropathology of Alzheimer's disease and related disorders
B4.25 Neuropathology of movement disorders
B4.26 Workshop on critical analysis of scientific papers
B4.27 Mammalian models of neurodegeneration
B4.28 Zebrafish as a model organism of neurodegenerative disease
B4.29 Writing a scientific abstract 1: Preparation
B4.30 Gene therapy for neurodegenerative disease
B4.31 Clinical trials relevant to neurodegenerative disease
B4.32 Pharmacological treatment of neurodegenerative disease
B4.33 Autophagy in Neurodegeneration
B4.34 Writing a scientific abstract 2: Review

Introduction to the clinico-anatomical correlation method
B5 - B7.1 Localizationist, holistic and associationist theories of brain function
Methods for assessing brain anatomy
B5 - B7.2 Surface, sectional, connectional anatomy 1
B5 - B7.3 Surface, sectional, connectional anatomy 2
B5 - B7.4 Maths and physics for neuroimaging
B5 - B7.5 Structural MRI
B5 - B7.6 Diffusion tensor imaging
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B5 - B7.7 Functional MRI physics and paradigm design
B5 - B7.8 Functional MRI analysis
B5 - B7.9 Interpretation of functional MRI studies
Methods for assessing cognition and behaviour
B5 - B7.10 Neuropsychological approaches in cognitive neuroscience
B5 - B7.11 Psychoemetric and electrophysiolgical methods in cognitive and affective neuroscience
B5 - B7.12 Experimental design and analysis: quantitative methods

B5.13 Introduction to the specialised neuroimaging module
B5.14 Basics of imaging
B5.15 SPET and PET blood flow
B5.16 PET receptor binding
B5.17 EEG and MEG
B5.18 Magnetic resonance spectroscopy and metabolite mapping
B5.19 Perfusion MRI
B5.20 Cortical mapping
B5.21 Neuroimaging in attention deficit hyperactivity disorder
B5.22 Pharmacological MRI
B5.23 Neuroimaging in schizophrenia
B5.24 Neuroimaging in depression and bipolar disorder
B5.25 Practicalities of scanning clinical populations
B5.26 Neuroimaging in autistic spectrum disorders
B5.27 Neuroimaging in anxiety and OCD
B5.28 Neuroimaging in addiction
B5.29 Neuroimaging in motor neurone disease
B5.30 Neuroimaging in pain
B5.31 Neuroimaging in epilepsy
B5.32 Neuroimaging in dementia
B5.33 Neuroimaging in multiple sclerosis
B5.34 Paper critiquing in neuroimaging

B6.13 Introduction to the specialised Functional Neuroimaging and Tractography research module
B6.14 Diffusion Imaging Tractography and virtual dissections
B6.15 Perisylvian pathways (interactive virtual dissections)
B6.16 Networks underlying language and praxis
B6.17 Aphasias and apraxias
B6.18 Dorsal fronto-parietal connections (interactive virtual dissections)
B6.19 Dorsal-fronto-parietal pathways for visuospatial processing
B6.20 Neglect syndromes
B6.21 Visual occipital networks (interactive virtual dissections)
B6.22 Visual occipital pathways and disorders of vision 1
B6.23 Visual occipital pathways and disorders of vision 2
B6.24 Interhemispheric callosal connections
B6.25 Callosal connections (interactive virtual dissections)
B6.26 Split brain and other callosal disconnection syndromes
B6.27 The limbic system and its disorders 1
B6.28 Limbic pathways (interactive virtual dissections)
B6.29 The limbic system and its disorders 2
B6.30 Projection pathways (interactive virtual dissections)
B6.31 Projection pathways and motor-sensory disorders 1
B6.32 Projection pathways and motor-sensory disorders 2
B6.33 Paper critiquing in tractography

B7.13 Introduction to the specialised Cognitive Neuroscience module
B7.14 Striatal and cerebellar systems involvement in cognition
B7.15 Neuroscience of attention and consciousness
B7.16 Functional neuroanatomy of working memory
B7.17 Neuroscience of cognitive control and self-regulation
B7.18 Neuroscience of timing processes
B7.19 Memory systems
B7.20 Neuroscience of language and speech
B7.21 Neuroscience of perception and imagery
B7.22 Social cognition I - theory of mind/ empathy
B7.23 Social cognition II - face and facial affect processing neural networks
B7.24 Social cognition III - neuroscience of fear, anxiety and defence
B7.25 The resting brain (default mode)
B7.26 Genetic influences in cognitive and brain functions
B7.27 Effects of pharamacological manipulations on cognitive and brain functions
B7.28 Cognitive and neural effects of drugs of abuse
B7.29 Sex differences in cognitive and brain functions
B7.30 Individual differences in brain and cognition functions
B7.31 Cognitive development: from infancy to adulthood
B7.32 Recovery and rehabilitation after brain damage
B7.33 Paper critiquing in Cognitive Neuroscience