MSc Neuroscience header image

MSc Neuroscience

at The Institute of Psychiatry, Psychology & Neuroscience, King's College London

Modules and Sections

This page contains the titles of all the lectures in the Fundamental and in the optional Specialised taught modules. The Specialised modules B1-B8 are not taught separately to the part-time students but part-time students will have the option to attend them when they are given to the full-time students on Mondays to Fridays in February of their second year. A selection of these specialised module lectures will be taught on Fridays in the module B Neuroscience for those students not able to attend lectures with the full-time students.

Fundamental module lectures within the different sections of each module
Fundamental Neuroscience

Basic chemistry tutorial
A1.1 Neuroanatomy and neuropathology
A1.1.1a Introduction to the rodent and human
A1.1.1b Introduction to brain structure/anatomy
A1.1.2 Research Methods I
A1.1.3 Research Methods II
A1.1.4 Biology of neurons - Jon Cooper
A1.1.5 Microglia and oligodendrocytes
A1.1.6 Astrocytes
A1.1.7 Introduction to neuropathology
A1.1.8 An overview of cerebral connectivity
A1.2 Cell biology
A1.2.1 Amino acids and proteins
A1.2.2 Molecular biology methods
A1.2.3 Molecular biology
A1.2.4 Growth, differentiation and death
A1.2.5 Concepts in cell biology
A1.2.6 Gene expression
A1.2.7 Apoptosis
A1.3 Neurotransmission
A1.3.1 Receptor isolation, purification and binding assays
A1.3.2 Receptor occupancy theory
A1.3.3 Membrane, synaptic and action potentials
A1.3.4 Use of cloning and expression systems to investigate ionotropic receptors
A1.3.5 Use of cloning and expression systems to investigate metabotropic receptors
A1.3.6 Structure and function of voltage and ligand-gated channels
A1.3.7 Techniques for monitoring neurotransmitters in vivo
A1.3.8 Pharmacology of glutamate and excitotoxicity
A1.4 Cell signalling
A1.4.1 Receptor-effector coupling: G proteins, adenylate cyclase and phosphatidylinositol
A1.4.2 Receptors and transcriptional regulation
A1.4.3 Cell-cell signalling 1
A1.4.4 Cell signalling 2
A1.4.5 Control of gene expression
A1.4.6 Neurotrophic factors

Fundamental Neuroscience

A2.1 Neurogenetics
A2.1.1 Mendelian genetics
A2.1.2 DNA and genotyping methods
A2.1.3 Linkage and association
A2.1.4 Genetics of complex diseases
A2.1.5 Genomics
A2.1.6 In vivo genetic models for neuroscience research 1
A2.1.7 In vivo genetic models for neuroscience research 2
A2.1.8 An Introduction to bioinformatics
A2.1.9 Epigenetics
A2.2 Developmental neurobiology
A2.2.1 Basic principles of neural development
A2.2.2 Patterning the brain
A2.2.3 Neurogenesis and migration
A2.2.4 Axon guidance
A2.2.5 Synapse formation
A2.2.6 Circuit formation
A2.2.7 Neurodevelopmental disorders
A2.2.8 Neural stem cells
A2.3 Neuronal plasticity
A2.3.1 Cortical map plasticity
A2.3.2 Long term potentiation
A2.3.3 Molecular manipulations to understand hippocampal function
A2.3.4 Neural Networks - I
A2.3.5 Neural Networks - II
A2.3.6 Neural Networks - III
A2.3.7 Neural Networks - IV
A2.4 Neuroimmunology
A2.4.1 Immune reactions in the CNS
A2.4.2 Antigen and molecular movement
A2.4.3 Cell migration into the CNS
A2.4.4 Antigen presentation
A2.4.5 Microglia
A2.4.6 Cytokines and cell activation
A2.4.7 Neuroimmunology; from basic immunology to disease treatment

Fundamental Neuroscience

A3.1 Systems neuroscience
A3.1.1 Pain and pain systems
A3.1.2 Hypothalamic pituitary axis - basic functioning
A3.1.3 Hypothalamic pituitary axis - clinical relevance
A3.1.4 Cognitive processing in cortico-striatal circuits
A3.1.5 Vision - part 1
A3.1.6 Vision - part 2
A3.1.7 Motor control
A3.2 Addiction biology
A3.2.1 Genetics of substance abuse
A3.2.2 Molecular biology of drug addiction
A3.2.3 Animal models and neurocircuitry of addiction
A3.2.4 Pharmacological and reinforcing effects of drugs in humans
A3.2.5 Concurrent addictive and psychiatric disorders
A3.3 Neuropsychology of mental health
A3.3.1 Testing cognitive function
A3.3.2 Clinical aspects of psychoses
A3.3.3 Neurobiology of psychoses
A3.3.4 Clinical aspects of affective disorders
A3.3.5 Neurobiology of affective disorders
A3.3.6 Dementia
A3.3.7 Neural substrates or normal and abnormal development
A3.3.8 Learning and memory in humans
A3.3.9 Animal models of psychiatric disease
A3.4 Neuroimaging
A3.4.1 Introduction to neuroimaging
A3.4.2 Basic principles of functional imaging
A3.4.3 Molecular and cellular MRI
A3.4.4 Brain hodology 1
A3.4.5 Brain hodology 2
A3.5 Neurodegeneration
A3.5.1 Molecular pathology of Alzheimer's disease
A3.5.2 Parkinson’s disease and related disorders
A3.5.3 Amyotropic lateral sclerosis and other motor neuron disorders
A3.5.4 Prion disorders
A3.5.5 Polyglutamine repeat disorders
A3.5.6 Neurodegenerative diseases of childhood

Optional specialised modules. Note that Module B is only available to the part-time students (see below).
Neuoroscience research

B.1 Parkinson's disease
B.2 Huntington's disease
B.3 Gene therapy for neurodegenerative disease
B.4 Clinical trials relevant to neurodegenerative disease
B.5 Autophagy in Neurodegeneration
B.6 The epidemiology of dementia
B.7 Gene - environment interactions
B.8 Epigenetics
B.9 Genetics of Alzheimer's disease and related dementias
B.10 Genetics of schizophrenia and bipolar disorder
Developmental Neurobiology
B.11 Neural induction
B.12 Axon pathfinding and disease modelling in Drosophila
B.13 Influencing the fate of embryonic neural progenitor cells
B.14 Stem cells and brain repair
B.15 Epigenetic regulation of neural development and neuropsychiatric disorders
B.16 Clinical Neuroimmunology
B.17 Virus diseases of the CNS
B.18 Bacterial and parasitic infections of the nervous system
DTI and Tractography
B.19 Networks underlying language and praxis
B.20 Aphasias and apraxias
B.21 Projection pathways (interactive virtual dissections)
B.22 Imaging techniques in drug addiction
B.23 Neuroimaging in schizophrenia
B.24 Neuroimaging in dementia
B.25 Neuroimaging in depression and bipolar disorder
Addiction Biology
B.26 Receptor pharmacology of major addictive drugs
B.27 Acute effects, sensitization and conditioned drug effects
B.28 TBA
B.29 TBA

Psychiatric Genetics

B1.1 Introduction to the B1 module
B1.2 The human genome
B1.3 The genetics of Alzheimer's disease and related dementias
B1.4 Genetic variation tutorial
B1.5 Quantitative genetics and the twin model
B1.6 Gene-environment interplay
B1.7 Epigenetics……the story continues
B1.8 Epigenetic techniques in neuroscience
B1.9 The genetics of autism spectrum disorders
B1.10 Genome-wide association studies
B1.11 Mouse models of autism spectrum disorders
B1.12 The genetics of anxiety and depression
B1.13 The genetics of bipolar disorder
B1.14 Functional genomics
B1.15 Bioinformatic tools for genetic analysis
B1.16 The genetics of addictive disorders
B1.17 The genetics of schizophrenia
B1.18 The genetics of ADHD
B1.19 Genetic and environmental influences on cognitive ability
B1.20 Next generation sequencing
B1.21 Working with 'omics data
B1.22 Basic statistics tutorial
B1.23 Human neural cell models for psychiatric illness
B1.24 Exploring effects of psychosis risk variants on brain function
B1.25 Preparation for abstract and written exam tutorial
B1.26 Genetic influences on cognition and brain functions

Developmental Neurobiology research

B3. Welcome and introduction
B3.1 Model organisms in developmental neurobiology research
B3.2 Neural induction
B3.3 Asymmetric division in the vertebrate neural tube
B3.4 Patterning the spinal cord
B3.5 Patterning the forebrain
B3.6 Patterning the Drosophila brain
B3.7 Connecting the periphery with higher brain centres: induction, patterning and wiring of the thalamus
B3.8 Cerebellum; neurogenesis, migration and circuit building
B3.9 Cortical development: cells, layers and areas
B3.10 Tutorial: Probabilities for Data Analysis
B3.11 The growth cone and cytoskeletal regulation
B3.12 Axon pathfinding and disease modelling in Drosophila
B3.13 Axon guidance of motorneurons
B3.14 Neuroendocrine systems and aging in C. elegans
B3.15 Tutorial: Writing an abstract Part I
B3.16 Retinotectal development
B3.17 Visual circuitry
B3.18 Olfactory neurogenesis and map formation
B3.19 Tutorial: Use of functional genomics in neural development
B3.20 Tutorial: Writing an abstract Part II
B3.21 The axon initial segment: Neural excitability and polarity
B3.22 Homeostatic plasticity during development
B3.23 Neurodevelopmental disorders of the synapse
B3.24 Neural activity and development of the retinotectal map
B3.25 Building functional circuits
B3.26 Stuctural plasticity in the cortex
B3.27 Transcriptional regulation of neural development and neurological disease
B3.28 Epigenetic regulation of neural development and neuropsychiatric disorders
B3.29 Adult neural stem cells
B3.30 Influencing the fate of embryonic neural progenitor cells
B3.31 Tutorial: The use of patient-specific iPS cells to model neurological disoders
B3.32 Stem cells and brain repair

degeneration research

B4.1 Introduction to the Module
B4.2 Epidemiology of Alzheimer's disease and other dementias
B4.3 Genetics of Alzheimer’s disease and related dementias
B4.4 Huntington's disease
B4.5 Neuroprotection in Parkinson's disease
B4.6 Paediatric storage disorders
B4.7 Prion disorders
B4.8 Multiple Sclerosis
B4.9 Genetics of Parkinson's disease
B4.10 Genetics of complex neurodegenerative disorders
B4.11 Processing of amyloid precursor protein in Alzheimer’s disease
B4.12 The role of the cytoskeleton in neurodegeneration
B4.13 Pathways of protein degradation
B4.14 Defects in axonal transport in neurodegenerative disease
B4.15 Mitochondria and neuronal energy balance
B4.16 Synaptic dysfunction in Alzheimer's disease
B4.17 Impaired RNA processing
B4.18 Calcium dysregulation in neurodegenerative disease
B4.19 Imaging in neurodegeneration
B4.20 Autophagy in Neurodegeneration
B4.21 Clinical and neuropathological aspects of movement disorders
B4.22 Neuropathology of Alzheimer's disease and related disorders
B4.23 Transcriptional dysregulation in neurodegeneration
B4.24 Phosphorylation mechanisms implicated in neurodegeneration
B4.25 Workshop on critical analysis of scientific papers
B4.26 Cell Signalling in Alzheimer's disease
B4.27 Drosophila as a model of neurodegenerative disease
B4.28 Mammalian models of neurodegeneration
B4.29 Biobehavioural assays of neurodegeneration
B4.30 Zebrafish as a model organism of neurodegene
rative disease
B4.31 Gene therapy for neurodegenerative disease
B4.32 Writing a scientific abstract 1: Exam Preparation
B4.33 Pharmacological treatment of neurodegenerative disease
B4.34 Writing a scientific abstract 2: Review of completed abstracts

B5 and B7 Common lectures

B5 - B7.1 Localizationist, holistic and associationist theories of brain function
B5 - B7.2 Structural MRI
B5 - B7.3 Introduction to Diffusion tensor imaging
B5 - B7.4 Advanced Diffusion tensor imaging
B5 - B7.5 Surface, sectional, connectional anatomy 1
B5 - B7.6 Surface, sectional, connectional anatomy 2
B5 - B7.7 Functional MRI physics and paradigm design (part 1)
B5 - B7.8 Functional MRI physics and paradigm design (part 2)
B5 - B7.9 Neuropsychological approaches in cognitive neuroscience
B5 - B7.10 Psychometric and electrophysiological methods in cognitive and affective neuroscience
B5 - B7.11 Functional MRI analysis (part 1)
B5 - B7.12 Functional MRI analysis (part 2)
B5 - B7.13 Experimental design and analysis : quantitative methods

Neural stem cells & nervous system repair research

B8.1 Introduction to the module
Neural stem cells biology and fate regulation
B8.2 Introduction to stem cells
B8.3 Introduction to stem cells: Focus on neural stem cells
B8.4 (also B3.5) Influencing the fate of neural stem cells
B8.5 (also B3.6) Transcriptional and epigenetic regulation of neural stem cells
B8.6 Neural stem cells in the adult: Hippocampal neurogenesis
B8.7 Drosophila model system for neurogenesis and gliogenesis
B8.8 Neural stem cells in the adult: the olfactory system
B8.9 Neurogenesis and cell signalling pathways: a focus on cannabinoids
B8.10 Neurogenesis and CNS injury
The use of neural stem cells as research tools
B8.11 (also B3.11) The use of patient-specific induced pluripotent stem cells (iPSCs) to model neurological disorders: Focus on methodology
B8.12 (also B3.12) iPSCs: Focus on autismGraham Cocks
B8.13 iPSCs: Focus on schizophrenia
B8.14 Hot topic in neural stem cells: article selection, critical reading and discussion
B8.15 The Human Induced Pluripotent Stem Cells Initiative (HipSci) project
B8.16 iPSCs: Focus on ALS
B8.17 iPSCs: Focus Alzheimer's disease
B8.18 Tutorial: Abstract writing session 1
B8.19a Neural Stem cells regulation: Focus on microRNA - Journal Club
B8.19b Neural Stem cells regulation: Focus on hormones - Journal Club
B8.19c Neural Stem cells regulation: Focus on ageing - Journal Club
Lab tour: Maurice Wohl Clinical Neuroscience Institute
Feedback questions - Sandrine Thuret
Study Day - Abstract preparation
Nervous system repair - The use of neural stem cells as regenerative technology
B8.20 Regeneration and protection within the CNS
B8.21 Immunological aspects of cell therapy
B8.22 Stem cell transplantation and spinal cord injury
B8.23 (also B3.25) Artificial CNS regeneration and stem-cell based neural implants
B8.24 Pain, injury and repair of the damaged nervous system
B8.25 Hot topic in nervous system repair: article selection, critical reading and discussion
Wolfson CARD lab tour
B8.26 Debate: Can human brain disease be modelled in a tissue culture dish?
B8.27 Neural stem cells and stroke
B8.28 Imaging of stem cells
B8.29 Imaging of brain repair
B8.30 Tutorial: Abstract and writing session 2
The use of neural stem cells : ethical, legal and commercialisation issues
B8.31 Commercialisation issues
B8.32 Novel neurotechnologies: intervening in the brain - ethical framework to guide practices
Debriefing and feedback sessions

Neuroimaging research

B5.14 Introduction to abstract writing (part 1)
B5.15 Paper Critiquing
B5.16 Tuesday Neuroimaging Seminar (optional)
B5.17 Neuroimaging in Epilepsy
B5.18 DTI Lab (part 1)
B5.19 Deafness & Sign Language
B5.20 Neuroimaging for Neurosurgery
B5.21 Mindfulness Neuroimaging
B5.22 Neuroimaging in Multiple Sclerosis
B5.23 Neuromarketing
B5.24 Neuroimaging in Dementia
B5.25 Abstract writing (part 2)
B5.26 Friday Neuroimaging Seminar (optional)
B5.27 Tuesday Neuroimaging Seminar
B5.28 Neuroimaging in schizophrenia
B5.29 DTI Lab (part 2)
B5.30 Neuroimaging in Autistic Spectrum Disorders
B5.31 Neuroimaging in ADHD
B5.32 Neuroimaging in depression
B5.33 Neuroimaging in bipolar disorder
B5.34 Neuroeconomics
B5.35 Friday Neuroimaging Seminar (optional)

Cognitive Neuroscience research

B7.14 Introduction to the specialised Cognitive Neuroscience module
B7.15 Neuroscience of attention and consciousness
B7.16 The resting brain (default mode)
B7.17 Memory systems
B7.18 Social cognition I - theory of mind/ empathy
B7.19 Neuroscience of perception and imagery
B7.20 Social cognition II - neuroscience of fear, anxiety and defence
B7.21 Social cognition III - face and facial affect processing neural networks
B7.22 Cerebellar systems involvement in cognition
B7.23 Functional neuroanatomy of working memory
B7.24 Neuropsychological Rehabilitation
B7.25 Neuroscience of language and speech
B7.26 Effects of pharmacological manipulations on cognitive and brain functions
B7.27 Cognitive and neural effects of drugs of abuse
B7.28 Paper critiquing in Cognitive Neuroscience - Session I
"B7.29 Neuroscience of cognitive control and self-regulation
B7.17 Neuroscience of cognitive control and self-regulation"
B7.30 Paper critiquing in Cognitive Neuroscience - Session II
B7.31 Genetic influences in cognitive and brain functions
B7.32 Neuroscience of timing processes
B7.33 Sex differences in brain and cognitive functions
B7.34 Cognitive and brain development: from infancy to adulthood
B7.35 Individual differences in cognitive and brain functions

Research projects. These are available within each of the above specialities (those classed as C fall outside these specialities).


Note that the Programme Committee reserves the right to alter the lecture content without notice if this is judged to improve the content of the programme.