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MSc Neuroscience

at The Institute of Psychiatry, Psychology & Neuroscience, King's College London

MSc project titles

Students submit a project report of between 7,500 and 10,000 words and prepare a poster of their project which is presented publicly in September and marked by the examiners.
The following are the titles of the projects carried out by the 2016-2017 full-time students and the 2014-2016 part-time students.

    Full-time
  • Investigating the role of small G protein Arl8B in controlling local pre-synapse formation.
  • Structural studies of ataxin-3 and its interactions.
  • Comparison of potentially therapeutic compounds for Neuronal Ceroid Lipofuscinosis (NCL).
  • Investigating the role of TSPO in mitonuclear interactions.
  • The role of Ellipsoid Body's D1-like Receptor in the initiation and maintenance of motor action and turning behaviour.
  • Analysing the role of autophagy in neural circuit development.
  • Revealing hemilineage based programs of cell death within the larval nervous system of Drosophila.
  • Regulation of neural stem cell quiescence by subcellular compartmentalisation.
  • An audit to refine the genotype-phenotype relationship for familial motor neurone disease (MND) and MND-frontotemporal dementia (MND-FTD) within the local regional population.
  • The role of coagulation factors in the development of AD pathology: Connecting blood and brain.
  • Expression of nicotinic receptor sub-units in early fetal human cerebral cortex.
  • Cellular and molecular characterisation of the formation of the pineal organ.
  • Hormonal regulation of hippocampal neurogenesis in the postpartum period: examining the combined effects of prolactin and oestrogen in an in vitro model of human hippocampal neurogenesis.
  • Protecting the blood-brain-barrier from toxic insult: a therapeutic role for natriuretic peptides in hepatic encephalopathy?
  • Visualising the functional development and maturation of presynaptic boutons.
  • Mechanisms of a-synuclein-induced synaptopathy in a Drosophila model of Parkinson’s disease.
  • Regulation of neural stem cell quiescence by subcellular compartmentalisation.
  • C9orf72 RAN-translated protein plays a key role in Amyotrophic Lateral Sclerosis via aggregation and toxicity.
  • Novel treatments for Parkinson's disease - a behavioural assessment study.
  • Imaging inflammation in the CNS.
  • Does the regulation of heparan sulfate proteoglycan sulfation influence the proliferation and migration of peripheral nerve sheath tumour derived Schwann cells?
  • Can the integration of cortical GWAS and brain expression Quantitative Trait Loci (eQTLs) boost our ability to identify genes that contribute to human cognitive abilities?
  • Characterisation of a novel teneurin-4 CRISPR mutant zebrafish line.
  • Role of the mitochondrial autophagy inhibitor TSPO sporadic Parkinson's disease models.
  • Investigating Amyotrophic Lateral Sclerosis using induced pluripotent stem cells: generation and phenotypic screening.
  • The role of cortico-thalamic projection neurons in attention and impulsivity.
  • Novel blood-based predictions of Alzheimer's disease pathology.
  • Mitochondria-endoplasmic reticulum interactions and autophagy in Parkinson's disease.
  • Investigating Dkk1 as a peripheral biomarker of Alzheimer's disease phenotypes.
  • Investigating the uptake properties of candidate peptides through the transferrin receptor for brain targeting of gold nanoparticles.
  • TREM2 signaling pathway leading to phagocytosis in Alzheimer's disease.
  • Turnover and degradation of the ALS-related protein FUS.
  • Characterising the effects of the Parkinson's Disease-linked LRRK2-G2019S mutation on SV2A expression in vivo as a function of age.
  • Exploring the exosome population in plasma from Alzheimer's disease.
  • Effects of pro-inflammatory cytokines (MIF & IL-1ß)on human hippcampal progenitor cells: an in vitro model of depression.
  • Ex-vivo validation of plasma fibrinogen gamma.
  • Investigating the role of EGFR in Alzheimer's disease.
  • Clusterin expression in acute head injury.
  • Studying the contribution of tau phosphorylation to tau release: implications for tau propagation in Alzheimer's disease.
  • Investigating the induction of Dickkopf-1 by beta-amyloid, its effect on beta-amyloid production and rescue by dietary B vitamins, 9 and 12.
  • Identification of Tenm3-positive cells in the nervous system and possible roles of this adhesion molecule in cell migration.
  • Does ebselen, potential lithium-mimetic, decrease synaptic glutamate availability?
  • Cortical progenitors in a mouse model of autism.
  • Regulation of GABAergic interneuron migration by EphB1/ephrin-B1 signalling.
  • GENESIS: Ketamine induced local protein synthesis and synapse formation.
  • Investigating potential changes in the morphology of neurons generated from a novel mouse model of human tauopathy.
  • Investigating the regulation of the intracellular transport of Alzheimer's disease related signalling molecules.
  • Investigating cellular clearance pathway functionality in a mouse model of TDP-43 linked ALS.
  • The role of apolipoprotein E in stem cell maintenance during hippocampal neurogenesis.
  • Effect of GBA on a-synuclein-mediated VAPB-PTPIP51 tethers.
  • Investigating the effect of chaperones on tau pathology.
  • Folic Acid as a modulator of Wnt signalling and APP processing.
  • Co-release of acetylcholine and GABA from layer 1 interneurons.
  • TGF-ß1 and BMP9 induced permeability of the blood brain barrier.
  • Role of Protocadherin 18 in the wiring of cortical interneurons.
  • Stress and depression: Assessing a model of stress in adult male mice.
  • Characterization of astrocytic and neuronal responses to human brain-derived abeta.
  • Modulation of the age at onset by CAG repeats of ataxia genes in Amyothrophic Lateral Sclerosis.
  • Understanding the cellular and molecular mechanisms underlying estrogenic modulation of social behaviours.
  • The study of the ethology of neurodevelopment disorders in cellular assays using patient-derived induced pluripotent stem cells.
  • In vivo tag of Foxg1 using genome editing in zebrafish.
  • Birthdating dopaminergic neurons in the mouse olfactory bulb.
  • Specification of cortical interneurons in health, neurological diseases, and stem cell therapy.
  • Identifying novel therapeutic targets for repair following spinal cord injury.
  • The dipeptide-repeat protein poly-GR leads to alterations in pre-synaptic structure in a Drosophila model of C9orf72-related ALS/FTD.
  • Do Sulf1/Sulf2 modulate glial cell growth, differentiation or migration?
  • Medulloblastoma Group 3: The role of KIAA1456 in cancer cell proliferation.

  • Using placebo analgesia to study sensory precision in autism and alexithymia.
  • Fast oscillations in the cerebellum.
  • The effects of verbal suggestion on body perception.
  • Describing novel frontal lobe tracts in correlation with neuropsychological measures.
  • The role of uncertainty in belief formation.
  • The effects of verbal suggestion on body perception.
  • Interoception and psychopathology.
  • Inter-individual variability of the three segments of the arcuate fasciculus in a large dataset processed with megatrack.
  • An investigation of immune-related mechanisms in schizophrenia.
  • The influence of reward priority on ERP signatures of attentional selection and learning in clinical populations.
  • A systematic review of the use of Immersive virtual reality to improve wellbeing and increase resilience.
  • Hubs of U-shaped fibres in the human (motor and sensory) homunculus.
  • Individual differences in perception of kinematic profiles in ASD and Control targets.
  • Evaluation of new semiautomatic analysis of white matter disconnection in stroke.
  • The effects of verbal suggestion on body perception.
  • The accuracy of clinical diagnosis in the Brains for Dementia Research cohort.
  • How do social skills and autistic traits affect us in old age? Exploring data from a huge on-line study of ageing.
  • Inter-individual variability of the occipital lobe networks in the human connectome dataset.
  • The influence of reward priority on ERP signatures of attentional selection and learning in clinical populations.
  • A systematic review of the use of virtual reality with children and teenagers in mental health.
  • Validating a quantitative method to measure brain atrophy in post-mortem examination of neurodegenerative diseases.
  • Characterising associations between psychosocial, environmental factors and infant temperament in the first year of life.
  • Amygdala resting state connectivity in chronic ketamine users.
  • Dissecting neurobiology of autism-associated aggression in a mouse model of autism spectrum disorder.
  • In patients with a psychotic disorder, do polygenic risks scores for obesity explain independently of antipsychotic treatment changes in body mass index between baseline and 5 years follow up?
  • Comparison of tractography algorithms for synthetic datasets and the visual system.
  • Nocebo effect: how neurobiological and psychosocial factors interact in the generation of headache pain.
  • Cerebral blood perfusion differences in anorexia nervosa following transcranial magnetic stimulation: a randomised control trial.
  • Affective resting networks in chronic ketamine users.
  • Is the corticolimbic hyperresponse to emotion observed in schizotypy driven by aberrant resting state connectivity of the hippocampus and striatum?
  • Cognitive Function in Early and Late Onset Depressive Disorder.
  • Predicting response to cognitive behavioural therapy for psychosis using supervised machine learning.
  • The influence of personality on cannabis use and psychotic experience in adolescents in South London.
  • Family environment and the persistence of ADHD into young adulthood? A prospective longitudinal study.
  • Investigating the relationship between severe mental illness and smoking cessation.
  • Investigating individual differences in response to non-invasive electrical stimulation.
  • The dorsal and ventral components of the cingulum dissected with tractography.
  • Attitudes to personalized medicine amongst psychiatrists.
  • Identifying individual differences in the neural signature of self-blame for future optimisation of fMRI neurofeedback training.
  • Tractography analysis for white matter networks of patients of stroke aphasia.
  • Segmenting the uncinate fasciculus into components related to behaviour, language and memory.
  • Neurobehavioural correlates of sensory symptoms in young people with tuberous sclerosis complex with and without autism spectrum disorder.
  • The role of primary and secondary visual cortices in reward processing.
  • DNA methylation and psychotic experiences at age 18.
  • Cognitive impairment and depressive symptoms in people with Parkinsons disease with LRRK2, GBA or SNCA mutations.
  • Mental health meets literature: definition of causative and contributing environmental factors.
  • A cross-sectional study investigating cognitive and functional impairments in euthymic Bipolar disorder.
    Part-time
  • Mechanisms underlying the development of tauopathy
  • p62 and autophagy in neurodegeneration
  • Using Super resolution microscopy to monitor nanoscopic changes in synapse structure on cortical neurons
  • Connectional and Functional Anatomy of the Uncinate Fasciculus
  • Is there an association between maternal childhood maltreatment and infant cognitive development? 
  • Stress, genes, brain and alcohol: association studies in adolescents 
  • Development of the axon initial segment in zebrafish larvae
  • Imaging inflammation in the CNS
  • How do late-onset Alzheimer's biomarkers relate to the early-onset AD phenotype?
  • Imaging ADHD: Cortical thickness and white matter comparisons between Responders and Non-Responders to stimulant treatment
  • Therapeutic testing for CLN2 disease
  • Maturation of white matter tracts in children and adolescents with Autism Spectrum Disorder.
  • Atlas-based autoradiography and registration to MRI
  • Autism and Ageing: examining 'theory of mind' and 'weak coherence' in relation to autistic traits and older age
  • Investigating how Wnt signallig effects the amyloidogenic processing of APP
  • Modelling Parkinson's disease in Drosophila Prion-likepathology of α-synuclein?
  • Mechanisms of traumatic brain injuries, GCS, and neurological outcomes
  • Functional network analysis in stroke patients with aphasia
  • A systematic review of the mechanisms underpinning delirium- A neuroscientific perspective
  • Sensorimotor gating in healthy individuals who experience symptoms of psychosis
  • Comparative anatomy of connectivity between early retinotopic maps and parahippocampal regions for spatial navigation
  • Non-nuclear role of RNA splicing proteins in motor dvelopment and degeneration.
  • Neuropsychiatric complications in phenylketonuria
  • Identifying intragyral white matter tracts