Professor Ammar Al-Chalabi MB ChB PhD FRCP DipStat
Professor of Neurology and Complex Disease Genetics
Honorary Consultant Neurologist, King's College Hospital
Director, King's MND Care and Research Centre
Instructor in Genetics of Complex Human Diseases, Cold Spring Harbor Laboratory, NY
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Institute of Psychiatry
MRC Centre for Neurodegeneration Research
Neurodegeneration and Brain Injury
Motor Neurone Disease (MND) / Amyotrophic Lateral Sclerosis (ALS)
SGDP Statistical Genetics Group
Ammar Al-Chalabi graduated from Leicester University Medical School in 1989, achieving two distinctions, merit, and three prizes. He came to King’s in 1994 as a clinician scientist working with Professor Leigh, studying genetic risk factors in motor neuron disease. He was awarded an MRC Clinical Training Fellowship in 1995. He obtained his PhD in 1999 and won a prestigious international award for outstanding research in the field of amyotrophic lateral sclerosis (motor neuron disease), The Charcot Young Investigator Prize. In 2000 he was awarded an MRC Clinician Scientist Fellowship. He became Professor of Neurology and Complex Disease Genetics in 2008 and is now Director of the King’s MND Care and Research Centre.
activities and interests
Motor Neuron Disease/Amyotrophic Lateral Sclerosis as a Complex Genetic Disease
TEAM: Alexey Shatunov: Post-doctoral Scientist, Ashley Jones: MRC PhD Student, Farzana Shah: Laboratory Technician, Kirsten Scott: F2A Fellow, Ricardo Rojas: Visiting Clinical Fellow, Bunmi Abel: Computer Scientist
Our group uses various methods to study the genetics of motor neuron disease/amyotrophic lateral sclerosis. We aim to find genes that make people susceptible to motor neuron disease, as well as genes that might affect age of onset or how aggressive the disease is.
Clinical Trials in ALS/MND
TEAM: Carlos Guevara: Clinical researcher, Marie Thornhill: Trials administrator, Andrew Dougherty, DeNDRoN Nurse
Chief Investigator, LiCALS trial of lithium in ALS, Principal Investigator, Trophos trial in ALS. Both now closed for recruitment. Further clinical trials may be available soon.
Motor Neuron Disease/Amyotrophic Lateral Sclerosis Epidemiology and Clinical Features
TEAM: Sarah Chapman: MND Specialist Nurse, Catherine Knights: Motor Nerve Clinic Coordinator, Kirsten Scott: Clinical researcher, Will Scotton: Clinical researcher
We have maintained a clinical database of patients attending the King’s Motor Nerve Clinic since 1994, and a population register of ALS for patients in the Lambeth-Southwark-Lewisham (LSL) catchment area for which we now have nine years of data. We run the South East ALS Register (SEALS Register). Our group is part of the EURALS ALS epidemiology consortium (Europe) and the ACES epidemiology conosrtium (USA).
UK Motor Neuron Disease DNA Bank (Sponsored by MNDA and Wellcome Trust)
TEAM (KCL): Barbara Coote, DNA Bank Nurse.
The MNDA DNA Bank is a national project aiming to collect DNA and clinical data from people with ALS/MND and unaffected controls over an eight year period. Samples and data are available to the research community through a Management Committee.
UK MNDA Epidemiology Study
ROLE: Lead Investigator.
This study is a case-control questionnaire to identify lifestyle risk factors that contribute to the development of motor neuron disease.
Natural History and Neuroprotection in Parkinson’s Plus Syndromes (NNIPPS) Study
ROLE: Genetics Technical Committee Member
Research into the genetics of Parkinson’s Plus Syndromes.
TEAM: John Powell: Co-investigator, Olubunmi Abel: Computer Scientist
Development of bioinformatics tools for genetic analysis including those at CoGeNT.
The ALS Online Database (ALSoD)
We have collaborations with colleagues in the UK (Guthrie Lab - KCL, Martin Lab - UCL, Fisher Lab - UCL, Garson Lab - UCL, Tobin Lab - Leicester, Shaw Lab - Sheffield, Morrison Lab - Birmingham) and internationally (Silani Lab - Milan, Robberecht Lab - Leuven, van den Berg Lab - Utrecht, Bensimon Lab - Paris, Brown Lab - Boston)
MRC Masterclass - Frontiers in Neurodegeneration Research
Role: Course organiser
Cold Spring Harbor Laboratory Course in Complex Disease Genetics
Programme Leader and Course Instructor
Wellcome Trust Masterclass - Controversies in motor neuron disease research and practice
Medical Student Teaching
Outpatient and ward-based teaching.
Module Leader, Module 1. Chair of Examination Board.
Supervisor. Please note, PhD studentships depend on successful funding.
Genetics of Complex Human Diseases (Amazon UK link)
The Brain: A Beginner’s Guide (Amazon UK link)
Peer-reviewed research and review articles with citation metrics available - please click the links below
Full publication list
Citations by year
Citation metrics by author
Collaboration network metrics
last updated: Wednesday, April 07, 2010