Professor Ammar Al-Chalabi  MB ChB PhD FRCP DipStat
Professor of Neurology and Complex Disease Genetics
Honorary Consultant Neurologist, King's College Hospital

Director, King's MND Care and Research Centre

Instructor in Genetics of Complex Human Diseases, Cold Spring Harbor Laboratory, NY

biography

Ammar Al-Chalabi graduated from Leicester University Medical School in 1989, achieving two distinctions, merit, and three prizes. He came to King’s in 1994 as a clinician scientist working with Professor Leigh, studying genetic risk factors in motor neuron disease. He was awarded an MRC Clinical Training Fellowship in 1995. He obtained his PhD in 1999 and won a prestigious international award for outstanding research in the field of amyotrophic lateral sclerosis (motor neuron disease), The Charcot Young Investigator Prize. In 2000 he was awarded an MRC Clinician Scientist Fellowship. He became Professor of Neurology and Complex Disease Genetics in 2008 and is now Director of the King’s MND Care and Research Centre.

activities and interests

Motor Neuron Disease/Amyotrophic Lateral Sclerosis as a Complex Genetic Disease

TEAM: Alexey Shatunov: Post-doctoral Scientist, Zita-Rose Manjalay: Foundation Year Clinical Fellow

Our group uses various methods to study the genetics of motor neuron disease/amyotrophic lateral sclerosis. We aim to find genes that make people susceptible to motor neuron disease, as well as genes that might affect age of onset or how aggressive the disease is.

Clinical Trials in ALS/MND

TEAM: Nigel Leigh: Lead investigator, Carlos Guevara: Clinical researcher, Marie Thornhill: Trials administrator

Our group is currently recruiting for trials of Lithium therapy and for the Trophos compound in ALS.

UK Motor Neuron Disease DNA Bank (Sponsored by MNDA and Wellcome Trust)

TEAM (KCL): Barbara Coote, DNA Bank Nurse.
The MNDA DNA Bank is a national project aiming to collect DNA and clinical data from people with ALS/MND and unaffected controls over an eight year period. Samples and data are available to the research community through a Management Committee.

UK MNDA Epidemiology Study

ROLE: Lead Investigator.
This study is a case-control questionnaire to identify lifestyle risk factors that contribute to the development of motor neuron disease.

Natural History and Neuroprotection in Parkinson’s Plus Syndromes (NNIPPS) Study

ROLE: Genetics Technical Committee Member

Research into the genetics of Parkinson’s Plus Syndromes.

Motor Neuron Disease/Amyotrophic Lateral Sclerosis Epidemiology and Clinical Features

TEAM: Mary Ann Ampong: MND Specialist Nurse, Kumar Abhinav: Clinical Research Assistant, Kirsten Scott: Clinical researcher, Will Scotton: Medical Student

We have maintained a clinical database of patients attending the King’s Motor Nerve Clinic since 1994, and a population register of ALS for patients in the Lambeth-Southwark-Lewisham (LSL) catchment area for which we now have seven years of data. We run the South East ALS Register (SEALS Register). Our group is part of the EURALS ALS epidemiology consortium (Europe) and the ACES epidemiology conosrtium (USA).

CoGeNT Research Group (Complex Genetics of Neurological Traits) Go to CoGeNT now!

This is a loose grouping of researchers interested in neurological diseases that do not follow simple Mendelian inheritance patterns. This includes epilepsy, Parkinsons disease and related disorders, multiple sclerosis and dementing conditions.

Collaborations

We have collaborations with colleagues in the UK (Guthrie Lab - KCL, Martin Lab - UCL, Fisher Lab - UCL, Garson Lab - UCL, Tobin Lab - Leicester, Shaw Lab - Sheffield, Morrison Lab - Birmingham) and internationally (Silani Lab - Milan, Robberecht Lab - Leuven, van den Berg Lab - Utrecht, Bensimon Lab - Paris, Brown Lab - Boston)

Bioinformatics

TEAM: John Powell: Co-investigator, Olubunmi Abel: Computer Scientist

Development of bioinformatics tools for genetic analysis including those at CoGeNT. We also maintain and develop the ALSOD ALS genetics database.

teaching activities

MRC Masterclass - Frontiers in Neurodegeneration Research

Role: Course organiser

Cold Spring Harbor Laboratory Course in Complex Disease Genetics

Programme Leader and Course Instructor

European ALS Young Investigator Meeting, London 2010

Role: Organiser

Wellcome Trust Masterclass - Controversies in motor neuron disease research and practice

Course organiser

Medical Student Teaching

Outpatient and ward-based teaching.

MSc Clinical Neuroscience

Programme Leader

PhD in Clinical Neuroscience

Supervisor. Please note, PhD studentships depend on successful funding.

publications

Books
Genetics of Complex Human Diseases (Amazon UK link)

The Brain: A Beginner’s Guide (Amazon UK link)

Peer-reviewed research and review articles
1: Lemmens R, Moore MJ, Al-Chalabi A, Brown RH Jr, Robberecht W. RNA metabolism
and the pathogenesis of motor neuron diseases. Trends Neurosci. 2010 Mar 11.
[Epub ahead of print] PubMed PMID: 20227117.


2: Manjaly ZR, Scott KM, Abhinav K, Wijesekera L, Ganesalingam J, Goldstein LH,
Janssen A, Dougherty A, Willey E, Stanton BR, Turner MR, Ampong MA, Sakel M,
Orrell RW, Howard R, Shaw CE, Leigh PN, Al-Chalabi A. The sex ratio in
amyotrophic lateral sclerosis: A population based study. Amyotroph Lateral Scler.
2010 Mar 12. [Epub ahead of print] PubMed PMID: 20225930.


3: Al-Chalabi A. Genome-wide association studies. CSH Protoc. 2009
Dec;2009(12):pdb.top66. PubMed PMID: 20150103.


4: Wain LV, Pedroso I, Landers JE, Breen G, Shaw CE, Leigh PN, Brown RH, Tobin
MD, Al-Chalabi A. The role of copy number variation in susceptibility to
amyotrophic lateral sclerosis: genome-wide association study and comparison with
published loci. PLoS One. 2009 Dec 4;4(12):e8175. PubMed PMID: 19997636; PubMed
Central PMCID: PMC2780722.


5: Chiò A, Logroscino G, Hardiman O, Swingler R, Mitchell D, Beghi E, Traynor BG;
Eurals Consortium. Prognostic factors in ALS: A critical review. Amyotroph
Lateral Scler. 2009 Oct-Dec;10(5-6):310-23. Review. PubMed PMID: 19922118.


6: Al-Chalabi A, Dürr A, Wood NW, Parkinson MH, Camuzat A, Hulot JS, Morrison KE,
Renton A, Sussmuth SD, Landwehrmeyer BG, Ludolph A, Agid Y, Brice A, Leigh PN,
Bensimon G; NNIPPS Genetic Study Group. Genetic variants of the alpha-synuclein
gene SNCA are associated with multiple system atrophy. PLoS One. 2009 Sep
22;4(9):e7114. PubMed PMID: 19771175; PubMed Central PMCID: PMC2743996.


7: Ganesalingam J, Stahl D, Wijesekera L, Galtrey C, Shaw CE, Leigh PN,
Al-Chalabi A. Latent cluster analysis of ALS phenotypes identifies prognostically
differing groups. PLoS One. 2009 Sep 22;4(9):e7107. PubMed PMID: 19771164; PubMed
Central PMCID: PMC2741575.


8: Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS,
Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR,
Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M,
Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd
S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor
M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I,
Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D,
Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens
K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling
H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M,
Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N,
Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O’Donovan M,
Owen MJ, Williams J. Genome-wide association study identifies variants at CLU and
PICALM associated with Alzheimer’s disease. Nat Genet. 2009 Oct;41(10):1088-93.
Epub 2009 Sep 6. Erratum in: Nat Genet. 2009 Oct;41(10):1156. PubMed PMID:
19734902; PubMed Central PMCID: PMC2845877.


9: van Es MA, Veldink JH, Saris CG, Blauw HM, van Vught PW, Birve A, Lemmens R,
Schelhaas HJ, Groen EJ, Huisman MH, van der Kooi AJ, de Visser M, Dahlberg C,
Estrada K, Rivadeneira F, Hofman A, Zwarts MJ, van Doormaal PT, Rujescu D,
Strengman E, Giegling I, Muglia P, Tomik B, Slowik A, Uitterlinden AG, Hendrich
C, Waibel S, Meyer T, Ludolph AC, Glass JD, Purcell S, Cichon S, Nöthen MM,
Wichmann HE, Schreiber S, Vermeulen SH, Kiemeney LA, Wokke JH, Cronin S,
McLaughlin RL, Hardiman O, Fumoto K, Pasterkamp RJ, Meininger V, Melki J, Leigh
PN, Shaw CE, Landers JE, Al-Chalabi A, Brown RH Jr, Robberecht W, Andersen PM,
Ophoff RA, van den Berg LH. Genome-wide association study identifies 19p13.3
(UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral
sclerosis. Nat Genet. 2009 Oct;41(10):1083-7. Epub 2009 Sep 6. PubMed PMID:
19734901.


10: Sabatelli M, Eusebi F, Al-Chalabi A, Conte A, Madia F, Luigetti M, Mancuso I,
Limatola C, Trettel F, Sobrero F, Di Angelantonio S, Grassi F, Di Castro A,
Moriconi C, Fucile S, Lattante S, Marangi G, Murdolo M, Orteschi D, Del Grande A,
Tonali P, Neri G, Zollino M. Rare missense variants of neuronal nicotinic
acetylcholine receptor altering receptor function are associated with sporadic
amyotrophic lateral sclerosis. Hum Mol Genet. 2009 Oct 15;18(20):3997-4006. Epub
2009 Jul 23. PubMed PMID: 19628475.


11: Fogh I, D’Alfonso S, Gellera C, Ratti A, Cereda C, Penco S, Corrado L, Sorarù
G, Castellotti B, Tiloca C, Gagliardi S, Cozzi L, Lupton MK, Ticozzi N, Mazzini
L, Shaw CE, Al-Chalabi A, Powell J, Silani V. No association of DPP6 with
amyotrophic lateral sclerosis in an Italian population. Neurobiol Aging. 2009 Jun
12. [Epub ahead of print] PubMed PMID: 19525032.


12: Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, Sapp
PC, van Vught PW, McKenna-Yasek DM, Blauw HM, Cho TJ, Polak M, Shi L, Wills AM,
Broom WJ, Ticozzi N, Silani V, Ozoguz A, Rodriguez-Leyva I, Veldink JH, Ivinson
AJ, Saris CG, Hosler BA, Barnes-Nessa A, Couture N, Wokke JH, Kwiatkowski TJ Jr,
Ophoff RA, Cronin S, Hardiman O, Diekstra FP, Leigh PN, Shaw CE, Simpson CL,
Hansen VK, Powell JF, Corcia P, Salachas F, Heath S, Galan P, Georges F, Horvitz
HR, Lathrop M, Purcell S, Al-Chalabi A, Brown RH Jr. Reduced expression of the
Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic
amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009 Jun
2;106(22):9004-9. Epub 2009 May 18. PubMed PMID: 19451621; PubMed Central PMCID:
PMC2683883.


13: Butler AW, Ng MY, Hamshere ML, Forabosco P, Wroe R, Al-Chalabi A, Lewis CM,
Powell JF. Meta-analysis of linkage studies for Alzheimer’s disease--a web
resource. Neurobiol Aging. 2009 Jul;30(7):1037-47. Epub 2009 Apr 11. PubMed PMID:
19362756.


14: Wills AM, Cronin S, Slowik A, Kasperaviciute D, Van Es MA, Morahan JM,
Valdmanis PN, Meininger V, Melki J, Shaw CE, Rouleau GA, Fisher EM, Shaw PJ,
Morrison KE, Pamphlett R, Van den Berg LH, Figlewicz DA, Andersen PM, Al-Chalabi
A, Hardiman O, Purcell S, Landers JE, Brown RH Jr. A large-scale international
meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology. 2009
Jul 7;73(1):16-24. Epub 2009 Mar 25. PubMed PMID: 19321847; PubMed Central PMCID:
PMC2707108.


15: Wijesekera LC, Mathers S, Talman P, Galtrey C, Parkinson MH, Ganesalingam J,
Willey E, Ampong MA, Ellis CM, Shaw CE, Al-Chalabi A, Leigh PN. Natural history
and clinical features of the flail arm and flail leg ALS variants. Neurology.
2009 Mar 24;72(12):1087-94. PubMed PMID: 19307543; PubMed Central PMCID:
PMC2821838.


16: Wicks P, Abrahams S, Papps B, Al-Chalabi A, Shaw CE, Leigh PN, Goldstein LH.
SOD1 and cognitive dysfunction in familial amyotrophic lateral sclerosis. J
Neurol. 2009 Feb;256(2):234-41. Epub 2009 Mar 1. PubMed PMID: 19252762.


17: Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X,
Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S,
Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller
CC, Shaw CE. Mutations in FUS, an RNA processing protein, cause familial
amyotrophic lateral sclerosis type 6. Science. 2009 Feb 27;323(5918):1208-11.
PubMed PMID: 19251628.


18: Lewis D, Ampong MA, Rio A, Willey E, Johnson J, Shaw CE, Ellis CM, Al-Chalabi
A, Leigh PN, Sidhu PS. Mushroom-cage gastrostomy tube placement in patients with
amyotrophic lateral sclerosis: a 5-year experience in 104 patients in a single
institution. Eur Radiol. 2009 Jul;19(7):1763-71. Epub 2009 Feb 4. PubMed PMID:
19190913.


19: Beleza-Meireles A, Al-Chalabi A. Genetic studies of amyotrophic lateral
sclerosis: controversies and perspectives. Amyotroph Lateral Scler. 2009
Feb;10(1):1-14. PubMed PMID: 19110986.


20: Diekstra FP, Beleza-Meireles A, Leigh NP, Shaw CE, Al-Chalabi A. Interaction
between PON1 and population density in amyotrophic lateral sclerosis.
Neuroreport. 2009 Jan 28;20(2):186-90. PubMed PMID: 19104460.


21: Hindocha N, Nabbout R, Elmslie F, Makoff A, Al-Chalabi A, Nashef L. A case
report of a family with overlapping features of autosomal dominant febrile
seizures and GEFS+. Epilepsia. 2009 Apr;50(4):937-42. Epub 2008 Nov 19. PubMed
PMID: 19054398.


22: Scott KM, Abhinav K, Stanton BR, Johnston C, Turner MR, Ampong MA, Sakel M,
Orrell RW, Howard R, Shaw CE, Leigh PN, Al-Chalabi A. Geographical clustering of
amyotrophic lateral sclerosis in South-East England: a population study.
Neuroepidemiology. 2009;32(2):81-8. Epub 2008 Nov 27. PubMed PMID: 19039239.


23: Bensimon G, Ludolph A, Agid Y, Vidailhet M, Payan C, Leigh PN; NNIPPS Study
Group. Riluzole treatment, survival and diagnostic criteria in Parkinson plus
disorders: the NNIPPS study. Brain. 2009 Jan;132(Pt 1):156-71. Epub 2008 Nov 23.
PubMed PMID: 19029129; PubMed Central PMCID: PMC2638696.


24: Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PW,
Landers JE, Sapp P, Van Den Bosch L, Knight J, Neale BM, Turner MR, Veldink JH,
Ophoff RA, Tripathi VB, Beleza A, Shah MN, Proitsi P, Van Hoecke A, Carmeliet P,
Horvitz HR, Leigh PN, Shaw CE, van den Berg LH, Sham PC, Powell JF, Verstreken P,
Brown RH Jr, Robberecht W, Al-Chalabi A. Variants of the elongator protein 3
(ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet. 2009
Feb 1;18(3):472-81. Epub 2008 Nov 7. PubMed PMID: 18996918; PubMed Central PMCID:
PMC2638803.


25: Shaw CE, Arechavala-Gomeza V, Al-Chalabi A. Chapter 14 Familial amyotrophic
lateral sclerosis. Handb Clin Neurol. 2007;82:279-300. PubMed PMID: 18808899.


26: Landers JE, Shi L, Cho TJ, Glass JD, Shaw CE, Leigh PN, Diekstra F, Polak M,
Rodriguez-Leyva I, Niemann S, Traynor BJ, McKenna-Yasek D, Sapp PC, Al-Chalabi A,
Wills AM, Brown RH Jr. A common haplotype within the PON1 promoter region is
associated with sporadic ALS. Amyotroph Lateral Scler. 2008 Oct;9(5):306-14.
PubMed PMID: 18618303; PubMed Central PMCID: PMC2739087.


27: Wroe R, Wai-Ling Butler A, Andersen PM, Powell JF, Al-Chalabi A. ALSOD: the
Amyotrophic Lateral Sclerosis Online Database. Amyotroph Lateral Scler. 2008
Aug;9(4):249-50. PubMed PMID: 18608099.


28: van de Giessen E, Fogh I, Gopinath S, Smith B, Hu X, Powell J, Andersen P,
Nicholson G, Al Chalabi A, Shaw CE. Association study on glutathione
S-transferase omega 1 and 2 and familial ALS. Amyotroph Lateral Scler. 2008
Apr;9(2):81-4. PubMed PMID: 18427999.


29: Lambrechts D, Poesen K, Fernández-Santiago R, Al-Chalabi A, Del Bo R, Van
Vught PW, Khan S, Marklund SL, Brockington A, van Marion I, Anneser J, Shaw C,
Ludolph AC, Leigh NP, Comi GP, Gasser T, Shaw PJ, Morrison KE, Andersen PM, Van
den Berg LH, Thijs V, Siddique T, Robberecht W, Carmeliet P. Meta-analysis of
vascular endothelial growth factor variations in amyotrophic lateral sclerosis:
increased susceptibility in male carriers of the -2578AA genotype. J Med Genet.
2009 Dec;46(12):840-6. Epub 2008 Apr 15. PubMed PMID: 18413368.


30: Ahmed BH, Ahmed A, Tan D, Awad ZT, Al-Aali AY, Kilkenny J 3rd, Orlando FA,
Al-Chalabi A, Crass R, Alrawi SJ. Post-laparoscopic cholecystectomy pain: effects
of intraperitoneal local anesthetics on pain control--a randomized prospective
double-blinded placebo-controlled trial. Am Surg. 2008 Mar;74(3):201-9. PubMed
PMID: 18376682.


31: Landers JE, Leclerc AL, Shi L, Virkud A, Cho T, Maxwell MM, Henry AF, Polak
M, Glass JD, Kwiatkowski TJ, Al-Chalabi A, Shaw CE, Leigh PN, Rodriguez-Leyza I,
McKenna-Yasek D, Sapp PC, Brown RH Jr. New VAPB deletion variant and exclusion of
VAPB mutations in familial ALS. Neurology. 2008 Apr 1;70(14):1179-85. Epub 2008
Mar 5. PubMed PMID: 18322265.


32: Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, Ackerley S,
Durnall JC, Williams KL, Buratti E, Baralle F, de Belleroche J, Mitchell JD,
Leigh PN, Al-Chalabi A, Miller CC, Nicholson G, Shaw CE. TDP-43 mutations in
familial and sporadic amyotrophic lateral sclerosis. Science. 2008 Mar
21;319(5870):1668-72. Epub 2008 Feb 28. PubMed PMID: 18309045.


33: Tripathi VB, Al-Chalabi A. Molecular insights and therapeutic targets in
amyotrophic lateral sclerosis. CNS Neurol Disord Drug Targets. 2008
Feb;7(1):11-9. Review. PubMed PMID: 18289027.


34: Hindocha N, Nashef L, Elmslie F, Birch R, Zuberi S, Al-Chalabi A, Crotti L,
Schwartz PJ, Makoff A. Two cases of sudden unexpected death in epilepsy in a
GEFS+ family with an SCN1A mutation. Epilepsia. 2008 Feb;49(2):360-5. PubMed
PMID: 18251839.


35: Beghi E, Mennini T, Bendotti C, Bigini P, Logroscino G, Chiò A, Hardiman O,
Mitchell D, Swingler R, Traynor BJ, Al-Chalabi A. The heterogeneity of
amyotrophic lateral sclerosis: a possible explanation of treatment failure. Curr
Med Chem. 2007;14(30):3185-200. Review. PubMed PMID: 18220753.


36: McCormick AL, Brown RH Jr, Cudkowicz ME, Al-Chalabi A, Garson JA.
Quantification of reverse transcriptase in ALS and elimination of a novel
retroviral candidate. Neurology. 2008 Jan 22;70(4):278-83. PubMed PMID: 18209202.


37: Vivekananda U, Johnston C, McKenna-Yasek D, Shaw CE, Leigh PN, Brown RH,
Al-Chalabi A. Birth order and the genetics of amyotrophic lateral sclerosis. J
Neurol. 2008 Jan;255(1):99-102. Epub 2007 Dec 19. PubMed PMID: 18060566.


38: Broom WJ, Johnson DV, Auwarter KE, Iafrate AJ, Russ C, Al-Chalabi A, Sapp PC,
McKenna-Yasek D, Andersen PM, Brown RH Jr. SOD1A4V-mediated ALS: absence of a
closely linked modifier gene and origination in Asia. Neurosci Lett. 2008 Jan
17;430(3):241-5. Epub 2007 Nov 6. PubMed PMID: 18055113.


39: Turner MR, Hammers A, Allsop J, Al-Chalabi A, Shaw CE, Brooks DJ, Leigh PN,
Andersen PM. Volumetric cortical loss in sporadic and familial amyotrophic
lateral sclerosis. Amyotroph Lateral Scler. 2007 Dec;8(6):343-7. PubMed PMID:
18033592.


40: Abhinav K, Stanton B, Johnston C, Hardstaff J, Orrell RW, Howard R, Clarke J,
Sakel M, Ampong MA, Shaw CE, Leigh PN, Al-Chalabi A. Amyotrophic lateral
sclerosis in South-East England: a population-based study. The South-East England
register for amyotrophic lateral sclerosis (SEALS Registry). Neuroepidemiology.
2007;29(1-2):44-8. Epub 2007 Sep 24. PubMed PMID: 17898523.


41: Al-Chalabi A. The multidisciplinary clinic, quality of life and survival in
motor neuron disease. J Neurol. 2007 Aug;254(8):1118. Epub 2007 Aug 11. PubMed
PMID: 17694351.


42: Isaacs JD, Dean AF, Shaw CE, Al-Chalabi A, Mills KR, Leigh PN. Amyotrophic
lateral sclerosis with sensory neuropathy: part of a multisystem disorder? J
Neurol Neurosurg Psychiatry. 2007 Jul;78(7):750-3. PubMed PMID: 17575021.


43: Fogh I, Rijsdijk F, Andersen PM, Sham PC, Knight J, Neale B, McKenna-Yasek D,
Silani V, Brown RH Jr, Powell JF, Al-Chalabi A. Age at onset in sod1-mediated
amyotrophic lateral sclerosis shows familiality. Neurogenetics. 2007
Aug;8(3):235-6. Epub 2007 Jun 5. PubMed PMID: 17549529.


44: Wicks P, Ganesalingham J, Collin C, Prevett M, Leigh NP, Al-Chalabi A. Three
soccer playing friends with simultaneous amyotrophic lateral sclerosis. Amyotroph
Lateral Scler. 2007 Jun;8(3):177-9. PubMed PMID: 17538780.


45: Kasperaviciute D, Weale ME, Shianna KV, Banks GT, Simpson CL, Hansen VK,
Turner MR, Shaw CE, Al-Chalabi A, Pall HS, Goodall EF, Morrison KE, Orrell RW,
Beck M, Jablonka S, Sendtner M, Brockington A, Ince PG, Hartley J, Nixon H, Shaw
PJ, Schiavo G, Wood NW, Goldstein DB, Fisher EM. Large-scale pathways-based
association study in amyotrophic lateral sclerosis. Brain. 2007 Sep;130(Pt
9):2292-301. Epub 2007 Apr 17. PubMed PMID: 17439985.


46: Turner MR, Rabiner EA, Al-Chalabi A, Shaw CE, Brooks DJ, Leigh PN, Andersen
PM. Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs
sporadic ALS. Neurology. 2007 Apr 10;68(15):1233-5. PubMed PMID: 17420412.


47: Turner MR, Hammers A, Al-Chalabi A, Shaw CE, Andersen PM, Brooks DJ, Leigh
PN. Cortical involvement in four cases of primary lateral sclerosis using
[(11)C]-flumazenil PET. J Neurol. 2007 Aug;254(8):1033-6. Epub 2007 Feb 9. PubMed
PMID: 17294065.


48: Johnston CA, Stanton BR, Turner MR, Gray R, Blunt AH, Butt D, Ampong MA, Shaw
CE, Leigh PN, Al-Chalabi A. Amyotrophic lateral sclerosis in an urban setting: a
population based study of inner city London. J Neurol. 2006 Dec;253(12):1642-3.
PubMed PMID: 17219036.


49: Abhinav K, Al-Chalabi A, Hortobagyi T, Leigh PN. Electrical injury and
amyotrophic lateral sclerosis: a systematic review of the literature. J Neurol
Neurosurg Psychiatry. 2007 May;78(5):450-3. Epub 2006 Nov 10. Review. PubMed
PMID: 17098839.


50: Simpson CL, Al-Chalabi A. Amyotrophic lateral sclerosis as a complex genetic
disease. Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):973-85. Epub 2006 Aug 5.
Review. PubMed PMID: 16973338.


51: Shaw CE, Al-Chalabi A. Susceptibility genes in sporadic ALS: separating the
wheat from the chaff by international collaboration. Neurology. 2006 Sep
12;67(5):738-9. PubMed PMID: 16966531.


52: Shaw AS, Ampong MA, Rio A, Al-Chalabi A, Sellars ME, Ellis C, Shaw CE, Leigh
NP, Sidhu PS. Survival of patients with ALS following institution of enteral
feeding is related to pre-procedure oximetry: a retrospective review of 98
patients in a single centre. Amyotroph Lateral Scler. 2006 Mar;7(1):16-21. PubMed
PMID: 16546754.


53: Vance C, Al-Chalabi A, Ruddy D, Smith BN, Hu X, Sreedharan J, Siddique T,
Schelhaas HJ, Kusters B, Troost D, Baas F, de Jong V, Shaw CE. Familial
amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus
on chromosome 9p13.2-21.3. Brain. 2006 Apr;129(Pt 4):868-76. Epub 2006 Feb 22.
PubMed PMID: 16495328.


54: Morita M, Al-Chalabi A, Andersen PM, Hosler B, Sapp P, Englund E, Mitchell
JE, Habgood JJ, de Belleroche J, Xi J, Jongjaroenprasert W, Horvitz HR,
Gunnarsson LG, Brown RH Jr. A locus on chromosome 9p confers susceptibility to
ALS and frontotemporal dementia. Neurology. 2006 Mar 28;66(6):839-44. Epub 2006
Jan 18. PubMed PMID: 16421333.


55: Nishimura AL, Al-Chalabi A, Zatz M. A common founder for amyotrophic lateral
sclerosis type 8 (ALS8) in the Brazilian population. Hum Genet. 2005
Dec;118(3-4):499-500. Epub 2005 Sep 27. PubMed PMID: 16187141.


56: Rio A, Ampong MA, Turner MR, Shaw AS, Al-Chalabi A, Shaw CE, Leigh PN, Sidhu
PS. Comparison of two percutaneous radiological gastrostomy tubes in the
nutritional management of ALS patients. Amyotroph Lateral Scler Other Motor
Neuron Disord. 2005 Sep;6(3):177-81. PubMed PMID: 16183559.


57: Turner MR, Osei-Lah AD, Hammers A, Al-Chalabi A, Shaw CE, Andersen PM, Brooks
DJ, Leigh PN, Mills KR. Abnormal cortical excitability in sporadic but not
homozygous D90A SOD1 ALS. J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1279-85.
PubMed PMID: 16107368; PubMed Central PMCID: PMC1739803.


58: Turner MR, Gerhard A, Al-Chalabi A, Shaw CE, Hughes RA, Banati RB, Brooks DJ,
Leigh PN. Mills’ and other isolated upper motor neurone syndromes: in vivo study
with 11C-(R)-PK11195 PET. J Neurol Neurosurg Psychiatry. 2005 Jun;76(6):871-4.
PubMed PMID: 15897516; PubMed Central PMCID: PMC1739672.


59: Turner MR, Hammers A, Al-Chalabi A, Shaw CE, Andersen PM, Brooks DJ, Leigh
PN. Distinct cerebral lesions in sporadic and ’D90A’ SOD1 ALS: studies with
[11C]flumazenil PET. Brain. 2005 Jun;128(Pt 6):1323-9. Epub 2005 Apr 20. PubMed
PMID: 15843422.


60: Meaburn E, Butcher LM, Liu L, Fernandes C, Hansen V, Al-Chalabi A, Plomin R,
Craig I, Schalkwyk LC. Genotyping DNA pools on microarrays: tackling the QTL
problem of large samples and large numbers of SNPs. BMC Genomics. 2005 Apr
5;6(1):52. PubMed PMID: 15811185; PubMed Central PMCID: PMC1079828.


61: Al-Chalabi A, Leigh PN. Trouble on the pitch: are professional football
players at increased risk of developing amyotrophic lateral sclerosis? Brain.
2005 Mar;128(Pt 3):451-3. Review. PubMed PMID: 15713848.


62: Simpson CL, Knight J, Butcher LM, Hansen VK, Meaburn E, Schalkwyk LC, Craig
IW, Powell JF, Sham PC, Al-Chalabi A. A central resource for accurate allele
frequency estimation from pooled DNA genotyped on DNA microarrays. Nucleic Acids
Res. 2005 Feb 8;33(3):e25. PubMed PMID: 15701753; PubMed Central PMCID:
PMC549427.


63: Steele AJ, Al-Chalabi A, Ferrante K, Cudkowicz ME, Brown RH Jr, Garson JA.
Detection of serum reverse transcriptase activity in patients with ALS and
unaffected blood relatives. Neurology. 2005 Feb 8;64(3):454-8. PubMed PMID:
15699374.


64: Turner MR, Rabiner EA, Hammers A, Al-Chalabi A, Grasby PM, Shaw CE, Brooks
DJ, Leigh PN. [11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in
sporadic ALS. Brain. 2005 Apr;128(Pt 4):896-905. Epub 2005 Feb 2. PubMed PMID:
15689356.


65: Broom WJ, Parton MJ, Vance CA, Russ C, Andersen PM, Hansen V, Leigh PN,
Powell JF, Al-Chalabi A, Shaw CE. No association of the SOD1 locus and disease
susceptibility or phenotype in sporadic ALS. Neurology. 2004 Dec
28;63(12):2419-22. PubMed PMID: 15623718.


66: Simpson CL, Hansen VK, Sham PC, Collins A, Powell JF, Al-Chalabi A. MaGIC: a
program to generate targeted marker sets for genome-wide association studies.
Biotechniques. 2004 Dec;37(6):996-9. PubMed PMID: 15597550.


67: Butcher LM, Meaburn E, Liu L, Fernandes C, Hill L, Al-Chalabi A, Plomin R,
Schalkwyk L, Craig IW. Genotyping pooled DNA on microarrays: a systematic genome
screen of thousands of SNPs in large samples to detect QTLs for complex traits.
Behav Genet. 2004 Sep;34(5):549-55. PubMed PMID: 15319578.


68: Leigh PN, Abrahams S, Al-Chalabi A, Ampong MA, Goldstein LH, Johnson J, Lyall
R, Moxham J, Mustfa N, Rio A, Shaw C, Willey E; King’s MND Care and Research
Team. The management of motor neurone disease. J Neurol Neurosurg Psychiatry.
2003 Dec;74 Suppl 4:iv32-iv47. Review. PubMed PMID: 14645465; PubMed Central
PMCID: PMC1765641.


69: Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL,
Wyns S, Thijs V, Andersson J, van Marion I, Al-Chalabi A, Bornes S, Musson R,
Hansen V, Beckman L, Adolfsson R, Pall HS, Prats H, Vermeire S, Rutgeerts P,
Katayama S, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L,
Vlietinck R, Morrison KE, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM,
Carmeliet P. VEGF is a modifier of amyotrophic lateral sclerosis in mice and
humans and protects motoneurons against ischemic death. Nat Genet. 2003
Aug;34(4):383-94. PubMed PMID: 12847526.


70: Ruddy DM, Parton MJ, Al-Chalabi A, Lewis CM, Vance C, Smith BN, Leigh PN,
Powell JF, Siddique T, Meyjes EP, Baas F, de Jong V, Shaw CE. Two families with
familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome
16q. Am J Hum Genet. 2003 Aug;73(2):390-6. Epub 2003 Jul 1. PubMed PMID:
12840784; PubMed Central PMCID: PMC1180376.


71: Al-Chalabi A, Scheffler MD, Smith BN, Parton MJ, Cudkowicz ME, Andersen PM,
Hayden DL, Hansen VK, Turner MR, Shaw CE, Leigh PN, Brown RH Jr. Ciliary
neurotrophic factor genotype does not influence clinical phenotype in amyotrophic
lateral sclerosis. Ann Neurol. 2003 Jul;54(1):130-4. PubMed PMID: 12838531.


72: Turner MR, Parton MJ, Shaw CE, Leigh PN, Al-Chalabi A. Prolonged survival in
motor neuron disease: a descriptive study of the King’s database 1990-2002. J
Neurol Neurosurg Psychiatry. 2003 Jul;74(7):995-7. PubMed PMID: 12810805; PubMed
Central PMCID: PMC1738535.


73: Al-Chalabi A, Hansen VK, Simpson CL, Xi J, Hosler BA, Powell JF,
McKenna-Yasek D, Shaw CE, Leigh PN, Brown RH Jr. Variants in the ALS2 gene are
not associated with sporadic amyotrophic lateral sclerosis. Neurogenetics. 2003
Aug;4(4):221-2. Epub 2003 May 27. PubMed PMID: 12768434.


74: Al-Chalabi A, Miller CC. Neurofilaments and neurological disease. Bioessays.
2003 Apr;25(4):346-55. Review. PubMed PMID: 12655642.


75: Turner M, Al-Chalabi A. Early symptom progression rate is related to ALS
outcome: a prospective population-based study. Neurology. 2002 Dec
24;59(12):2012-3; author reply 2013. PubMed PMID: 12499513.


76: Parton MJ, Broom W, Andersen PM, Al-Chalabi A, Nigel Leigh P, Powell JF, Shaw
CE; D90A SOD1 ALS Consortium. D90A-SOD1 mediated amyotrophic lateral sclerosis: a
single founder for all cases with evidence for a Cis-acting disease modifier in
the recessive haplotype. Hum Mutat. 2002 Dec;20(6):473. PubMed PMID: 12442272.


77: Turner MR, Bakker M, Sham P, Shaw CE, Leigh PN, Al-Chalabi A. Prognostic
modelling of therapeutic interventions in amyotrophic lateral sclerosis.
Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Mar;3(1):15-21. PubMed
PMID: 12061944.


78: Shaw CE, al-Chalabi A, Leigh N. Progress in the pathogenesis of amyotrophic
lateral sclerosis. Curr Neurol Neurosci Rep. 2001 Jan;1(1):69-76. Review. PubMed
PMID: 11898502.


79: Lloyd CM, Richardson MP, Brooks DJ, Al-Chalabi A, Leigh PN. Extramotor
involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil. Brain.
2000 Nov;123 ( Pt 11):2289-96. PubMed PMID: 11050028.


80: Al-Chalabi A, Leigh PN. Recent advances in amyotrophic lateral sclerosis.
Curr Opin Neurol. 2000 Aug;13(4):397-405. Review. PubMed PMID: 10970056.


81: Andrews WD, Tuke PW, Al-Chalabi A, Gaudin P, Ijaz S, Parton MJ, Garson JA.
Detection of reverse transcriptase activity in the serum of patients with motor
neurone disease. J Med Virol. 2000 Aug;61(4):527-32. PubMed PMID: 10897073.


82: Al-Chalabi A, Andersen PM, Nilsson P, Chioza B, Andersson JL, Russ C, Shaw
CE, Powell JF, Leigh PN. Deletions of the heavy neurofilament subunit tail in
amyotrophic lateral sclerosis. Hum Mol Genet. 1999 Feb;8(2):157-64. PubMed PMID:
9931323.


83: Hu MT, Ellis CM, Al-Chalabi A, Leigh PN, Shaw CE. Flail arm syndrome: a
distinctive variant of amyotrophic lateral sclerosis. J Neurol Neurosurg
Psychiatry. 1998 Dec;65(6):950-1. PubMed PMID: 9854987; PubMed Central PMCID:
PMC2170397.


84: Al-Chalabi A, Andersen PM, Chioza B, Shaw C, Sham PC, Robberecht W, Matthijs
G, Camu W, Marklund SL, Forsgren L, Rouleau G, Laing NG, Hurse PV, Siddique T,
Leigh PN, Powell JF. Recessive amyotrophic lateral sclerosis families with the
D90A SOD1 mutation share a common founder: evidence for a linked protective
factor. Hum Mol Genet. 1998 Dec;7(13):2045-50. PubMed PMID: 9817920.


85: Shaw CE, Enayat ZE, Chioza BA, Al-Chalabi A, Radunovic A, Powell JF, Leigh
PN. Mutations in all five exons of SOD-1 may cause ALS. Ann Neurol. 1998
Mar;43(3):390-4. PubMed PMID: 9506558.


86: Andrews WD, Al-Chalabi A, Garson JA. Lack of evidence for HTLV tax-rex DNA in
motor neurone disease. J Neurol Sci. 1997 Dec 9;153(1):86-90. PubMed PMID:
9455984.



88: Jackson M, Al-Chalabi A, Enayat ZE, Chioza B, Leigh PN, Morrison KE.
Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis:
analysis of 155 cases and identification of a novel insertion mutation. Ann
Neurol. 1997 Nov;42(5):803-7. PubMed PMID: 9392581.


89: Abrahams S, Goldstein LH, Al-Chalabi A, Pickering A, Morris RG, Passingham
RE, Brooks DJ, Leigh PN. Relation between cognitive dysfunction and pseudobulbar
palsy in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 1997
May;62(5):464-72. PubMed PMID: 9153602; PubMed Central PMCID: PMC486852.


90: Hoda F, Nicholl D, Bennett P, Arranz M, Aitchison KJ, al-Chalabi A, Kunugi H,
Vallada H, Leigh PN, Chaudhuri KR, Collier DA. No association between Parkinson’s
disease and low-activity alleles of catechol O-methyltransferase. Biochem Biophys
Res Commun. 1996 Nov 21;228(3):780-4. PubMed PMID: 8941353.


91: Jackson M, Morrison KE, Al-Chalabi A, Bakker M, Leigh PN. Analysis of
chromosome 5q13 genes in amyotrophic lateral sclerosis: homozygous NAIP deletion
in a sporadic case. Ann Neurol. 1996 Jun;39(6):796-800. PubMed PMID: 8651652.


92: al-Chalabi A, Enayat ZE, Bakker MC, Sham PC, Ball DM, Shaw CE, Lloyd CM,
Powell JF, Leigh PN. Association of apolipoprotein E epsilon 4 allele with
bulbar-onset motor neuron disease. Lancet. 1996 Jan 20;347(8995):159-60. PubMed
PMID: 8544551.


93: al-Chalabi A, Abbott RJ. Angiotropic lymphoma in the differential diagnosis
of systemic vasculitis. J Neurol Neurosurg Psychiatry. 1995 Aug;59(2):219. PubMed
PMID: 7629549; PubMed Central PMCID: PMC486012.


94: al-Chalabi A, Powell JF, Leigh PN. Neurofilaments, free radicals,
excitotoxins, and amyotrophic lateral sclerosis. Muscle Nerve. 1995
May;18(5):540-5. Review. PubMed PMID: 7739643.


95: al-Chalabi A, Sivakumaran M, Holton J, West KP, Wood JK, Abbott RJ. A case of
intravascular malignant lymphomatosis (angiotropic lymphoma) with raised
perinuclear antineutrophil cytoplasmic antibody titres--a hitherto unreported
association. Clin Lab Haematol. 1994 Dec;16(4):363-9. PubMed PMID: 7736714.