Dr Leonard C Schalkwyk PhD
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| contact this person | |
| tel | +44 (0) 207 848 0279 |
| fax | +44 (0) 207 848 0866 |
| address | Institute of Psychiatry |
| location | c110 MRC, SGDP Centre |
| departments | Social, Genetic and Developmental Psychiatry (IRG) Social, Genetic and Developmental Psychiatry Centre (MRC) |
| also | GENDEP |
biography
Leo Schalkwyk has been at the SGDP Research Centre since the spring of 2000 where he works on functional genomics, identifying genes involved in behaviour in the mouse. His group studies phenotypes related to activity, anxiety and cognition, and have recently undertaken a large genotype-environment interaction study related to depression. They also have interests in developing technology related to genotyping/allelotyping/DNA methylation, gene expression and bioinformatics.
Dr Schalkwyk previously worked at the Max-Planck-Institut für molekulare Genetik in Berlin and before that in Hans Lehrach’s laboratory at the Imperial Cancer Research Fund laboratory in London. He is originally a microbiologist from Canada, and studied Microbiology at the University of Alberta in Edmonton, graduating in 1983. He completed his PhD in Biochemistry at Dalhousie University in 1991. His PhD work was on genome mapping of Haloferax, an archaeon from the Dead Sea, with Ford Doolittle.
The SGDP runs a very interesting annual Summer School.
teaching activities
SGDP summer school: Introduction to R 2011, 2012
publications
Bibliography with citation counts at ResearcherIDGoogle Scholar Profile
Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, R.Plomin, and Mill J(2013). Methylomic Analysis of Monozygotic Twins Discordant for Autism Spectrum Disorder (ASD) and Related Behavioural Traits Molecular Psychiatry
Kõks S, Overall RW, Ivask M, Soomets U, Guha M, Vasar E, Fernandes C, and Schalkwyk LC(2013). Silencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage Physiological Genomics .
Pidsley R, Fernandes C, Viana J, Paya-Cano JL, Liu L, Smith RG, Schalkwyk LC, and Mill J(2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice Mol Brain 5:42.
Navarrete K, Pedroso I, De Jong S, Stefansson H, Steinberg S, Stefansson K, Ophoff R, Schalkwyk LC, and Collier DA (2012). TCF4 (e2-2; ITF2): A Schizophrenia-Associated Gene With Pleiotropic Effects on Human Disease. American Journal of Medical Genetics Part B
Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, and Mill J (2012). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Molecular Psychiatry.
Malki K, Lourdusamy A, Binder E, Payá-Cano J, Sluyter F, Craig I, Keers R, McGuffin P, Uher R, and Schalkwyk LC (2012). Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression. Pharmacogenet. Genomics.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, Al-Sarraj S, Dobson R, Schalkwyk LC, and Mill J (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biology 13.
Parsons MJ, Grimm C, Paya-Cano JL, Fernandes C, Lin L, Philip VM, Chesler EJ, Nietfeld W, Lehrach H, and Schalkwyk LC (2012). Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains. BMC Genomics 13:476.
Kember RL, Dempster EL, Lee THA, Schalkwyk LC, Mill J, and Fernandes C (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. Brain Behav 2:455-467.
Malki K, Campbell J, Davies M, Keers R, Uher R, Ward M, Paya-Cano J, Aitchinson KJ, Binder E, Sluyter F, Kuhn K, Selzer S, Craig I, McGuffin P, and Schalkwyk LC (2012). Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains. Proteomics 12:2355-2365.
Keers R, Pedroso I, Breen G, Aitchison KJ, Nolan PM, Cichon S, Nothen MM, Rietschel M, Schalkwyk LC, and Fernandes C (2012). Reduced Anxiety and Depression-Like Behaviours in the Circadian Period Mutant Mouse Afterhours.Plos One 7.
Jeffries AR, Perfect LW, Ledderose J, Schalkwyk LC, Bray NJ, Mill J, and Price J (2012). Stochastic Choice of Allelic Expression in Human Neural Stem Cells. Stem Cells 30:1938-1947.
Powell TR, Schalkwyk LC, Heffernan AL, Breen G, Lawrence T, Price T, Farmer AE, Aitchison KJ, Craig IW, Danese A, Lewis C, McGuffin P, Uher R, Tansey KE, and D’Souza UM (2012). Tumor Necrosis Factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response. European Neuropsychopharmacologyin press.
Kõks S, Soomets U, Plaas M, Terasmaa A, Noormets K, Tillmann V, Vasar E, Fernandes C, Schalkwyk LC (2011). Hypothalamic gene expression profile indicates a reduction in G-protein signalling in the Wfs1 mutant mice. Physiological Genomics 43(24):1351-1358 doi:10.1152/physiolgenomics.00117.2011
Binder E, Malki K, Payá-Cano JL, Fernandes C, Aitchison KJ, Mathé A, Sluyter F, Schalkwyk LC (2011). Antidepressants and the resilience to early-life stress in inbred mouse strains. Pharmacogenetics and Genomics 21(12):779¿789 doi: 10.1097/FPC.0b013e32834b3f35
Sikk K, Kõks S, Soomets U, Schalkwyk LC, Fernandes C, Haldre S, Aquilonius SM, Taba P (2011). Peripheral blood RNA gene expression profiling in illicit methcathinone users reveals effect on immune system. Frontiers in Neurogenomics 2:42 doi: 10.3389/fgene.2011.00042
Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, Murray RM, Mill J (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet. PMID: 21908516 doi: 10.1093/hmg/ddr416
Schughart K, Arends D, Andreux P, Balling R, Beyer A, Bezerianos A, Brockmann GA, Crusio WE, Campbell-Tofte J, Denny P, Falcon-Perez JM, Forejt J, Franken P, Hovatta I, Iraqi F, Jansen RC, Kaczmarek L, Kas MJ, Kashofer K, Knapska E, Kolisis F, Kõks S, Lammert F, Möller S, Montagutelli X, Morahan G, Mott R, Pfoertner S, Prins P, Przewlocki R, Ranki A, Santos J, Rihet P, Schalkwyk L, Smit AB, Swertz M, Threadgill D, Vasar E, Zatloukal K (2010) SYSGENET: a meeting report from a new European network for systems genetics. Mamm Genome. 21(7-8):331-6.
Schosser A, Pirlo K, Gaysina D, Cohen-Woods S, Schalkwyk LC, Elkin A, Korszun A, Gunasinghe C, Gray J, Jones L, Meaburn E, Farmer AE , Craig I, McGuffin P (2010). Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays. BMC Research Notes 3:274
Davies M, Meaburn EL, Schalkwyk LC (2010). Gene Set Enrichment; a problem of pathways. Briefings in Functional Genomics 9(5-6):385-90. doi: 10.1093/bfgp/elq021
Malki K, Uher R, Payá-Cano J, Binder E, Rietschel M, Zobel A, Mors O, Hauser J, Henigsberg N, Jerman B, Souery D, Placentino A, Ng M, Cohen-Woods S, Sluyter F, Farmer A, Aitchison KJ, Craig I, Lewis C, McGuffin P, Schalkwyk LC (2011). Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants, Biological Psychiatry69:360-365 doi:10.1016/j.biopsych.2010.08.011
Meaburn EL, Schalkwyk LC, Mill J (2010) Allele-specific methylation in the human genome: Implications for genetic studies of complex disease Epigenetics 5(7):578-582
Kember RL, Fernandes C, Tunbridge EM, Liu L, Payá-Cano JL, Parsons MJ, Schalkwyk LC (2010). A B2 SINE insertion in the Comt1 gene (Comt1B2i) results in overexpressing, behavior modifying allele present in classical inbred mouse strains. Genes, Brain and Behavior.9(8):925-932 DOI:10.1111/j.1601-183X.2010.00614.x
Davis OS, Butcher LM, Docherty SJ, Meaburn EL, Curtis CJ, Simpson MA, Schalkwyk LC, Plomin R (2010). A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Behavior Genetics 40(6):759-767 DOI:10.1007/s10519-010-9350-4
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. American Journal of Human Genetics 86:1-18. -- commentary -- author manuscript--data
Ronald A, Butcher LM, Docherty S, Davis OSP, Schalkwyk LC, Craig IW, Plomin R (2010). Response to comment by Stuart Macgregor Behavior Genetics 40(1):48. DOI 10.1007/s10519-009-9319-3
Ronald A, Butcher LM, Docherty S, Davis OSP, Schalkwyk LC, Craig IW, Plomin R (2010). A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples Behavior Genetics 40(1):31-45. doi: 10.1007/s10519-009-9308-6 PMC2797846
Lad HV, Liu L, Payá-Cano JL, Parsons MJ, Kember R, Fernandes C, Schalkwyk LC (2010). Behavioural battery testing: evaluation and behavioural outcomes in 8 inbred mouse strains Physiology & Behavior 99:(3)301-316 doi:10.1016/j.physbeh.2009.11.007
Smith RG, Kember RL, Mill J, Fernandes C, Schalkwyk LC, Buxbaum JD, Reichenberg A. (2009). Advancing Paternal Age is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model. PLoS ONE 4(12): e8456. doi: 10.1371/journal.pone.0008456 PMC2794376
Kõks S, Velthut A, Sarapik A, Altmäe S, Reinmaa E, Schalkwyk LC, Fernandes C, Lad HV, Soomets U, Jaakma Ü, Salumets A. (2009). The differential transcriptome and ontology profiles of mural and cumulus granulosa cells in stimulated human antral follicles. MHR 16(4):229-240 doi:10.1093/molehr/gap103
Docherty SJ, Davis OS, Kovas Y, Meaburn EL, Dale PS, Petrill SA, Schalkwyk LC, Plomin R (2009) A genome-wide association study identifies multiple loci associated with mathematics ability and disability. Genes, Brain and Behavior 9(2):234-247 doi:10.1111/j.1601-183X.2009.00553.x
Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW (2009). Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Frontiers in Neuroscience 3:55.
Davies MN, Lawn S, Whatley S, Fernandes C, Williams RW, Schalkwyk LC (2009). To what extent is blood a reasonable surrogate for brain in gene expression studies: estimation from mouse hippocampus and spleen. Frontiers in Neuroscience 3:54.
Meaburn EL, Fernandes C, Craig IW, Plomin R, Schalkwyk LC(2009). Assessing individual differences in genome-wide gene expression in human whole blood: reliability over four hours and stability over 10 months. Twin Res Hum Genet. 12(4):372-80.
Kõks S, Soomets U, Payá-Cano J, Fernandes C, Luuk H, Plaas M, Terasmaa A, Tillmann V, Noormets K, Vasar E, Schalkwyk LC (2009). Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway. Physiological Genomics 37(3):249-59.
Amos-Landgraf J, Schalkwyk LC(2008) The 21st International Mammalian Genome Conference Meeting Report. Mammalian Genome 19(9):618-622.
Davis OSP, Plomin R, Schalkwyk LC(2008). The SNPMaP package for R: A framework for genome-wide association using DNA pooling on microarrays. Bioinformatics 2009 25: 281-283.
Parsons MJ, Grimm CH, Payá-Cano JL, Sugden K, Nietfeld W, Lehrach H, Schalkwyk LC(2008). Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mammalian Genome 19(7-8):552-560.
Kas MJH, Gelegen C, Schalkwyk LC, Collier DA (2008). Interspecies comparisons of functional genetic variations and their implications in neuropsychiatry. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(3):309-17.
Kõks S, Fernandes C, Kurrikoff K, Vasar E, Schalkwyk LC (2008). Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice, Behavioural Brain Research 188:62-70.
Caspi A, Williams B, Kim-Cohen J, Craig IW, Milne BJ, Poulton R, Schalkwyk LC, Taylor A, Werts H, Moffitt TE (2007.) Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism PNAS 104(47):18860-18865..
Lad HV, Liu L, Payá-Cano JL, Fernandes C, Schalkwyk LC (2007). Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping. Mammalian Genome 18(6-7):482-91.
Meaburn E, Harlaar N, Craig IW, Schalkwyk LC, Plomin R (2008). QTL association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5,500 children. Molecular Psychiatry 13:729â¿¿740.
Docherty SJ, Butcher LM, Schalkwyk LC, Plomin R (2007). Applicability of DNA pools on 500K SNP microarrays for cost-effective initial screens in genomewide association studies. BMC Genomics. 2007 Jul 4;8(1):214.
Schalkwyk LC, Fernandes C, Nash MW, Kurrikoff K, Vasar E, Kõks S (2007). Interpretation of knockout experiments: the congenic footprint. Genes, Brain and Behavior 6: 299⿿303-- faculty 1000 evaluation -- comment in The Scientist.
Plomin R, Schalkwyk LC (2007). Microarrays. Developmental Science 10(1):19â¿¿23.
Kas MJH, Fernandes C, Schalkwyk LC, Collier DA (2007). Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men. Molecular Psychiatry 12(4):324-30.
Meaburn E, Butcher LM, Schalkwyk LC, Plomin R (2006). Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans. Nucleic Acids Research 34(4):e27.
Fernandes C, Hoyle E, Dempster E, Schalkwyk LC, Collier D (2006) α7 nicotinic receptor knockout impairs working/episodic-like memory in the delayed matching-to-place (DMP) version of the Morris water maze. Genes, Brain and Behaviour 5:433-440.
Schalkwyk LC Complex trait approaches to the analysis of behaviour in the mouse (2005). Psychiatry 4(12):18-21.
Galsworthy MJ, Payá-Cano JL, Liu L, Monleon S, Gregoryan G, Fernandes C, Schalkwyk LC, Plomin R (2005). Assessing Reliability, Heritability and General Cognitive Ability in a Battery of Cognitive Tasks for Laboratory Mice. Behav Genet. 35(5):675-692.
Meaburn E, Butcher LM, Liu L, Fernandes C, Hansen V, Al-Chalabi A, Plomin R, Craig I, Schalkwyk LC (2005). Genotyping DNA pools on microarrays: Tackling the QTL problem of large samples and large numbers of SNPs. BMC Genomics. 6(1):52
Butcher LM, Meaburn E, Knight J, Sham PC, Schalkwyk LC, Craig IW, Plomin R (2005). SNPs, microarrays, and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. Human Molecular Genetics 14(10):1315-1325.
Simpson C, Knight J, Butcher L, Hansen V, Meaburn E, Schalkwyk LC , Craig I, Powell J, Sham P, Al-Chalabi A (2005). A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays Nucleic Acids Research 33(3):e25
Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty ,J Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ P, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder JR, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, Pardo-Manuel de Villena F, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Min Z, Zou F (2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics 36, 1133 - 1137
Butcher LM, Meaburn E, Dale PS, Sham P, Schalkwyk LC, Craig IW and Plomin R (2005). Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms. Mol Psychiatry. 10(4):384-92.
Fernandes C, Liu L, Paya-Cano JL, Gregorová S, Forejt J and Schalkwyk LC (2004). Behavioural characterisation of wild derived male mice (Mus musculus musculus) of the PWD/Ph inbred strain. Behavior Genetics 34:621-783
Butcher LM, Meaburn E, Liu L, Fernandes C, Hill L, Al-Chalabi A, Plomin R, Schalkwyk LC, Craig IW (2004). Genotyping Pooled DNA on Microarrays: A Systematic Genome Screen of Thousands of SNPs in Large Samples to Detect QTLs for Complex Traits. Behav Genet. 34(5):549-55.
Abdelkhalek HB, Beckers A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Muller I, Herrmann BG, Ceolin M, Rivera-Pomar R, Gossler A (2004). The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev. 18(14):1725-36.
Craig IW, Mill J, Craig GM, Loat C, Schalkwyk LC (2004). Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes. Eur J Hum Genet. 12(8):639-46.
Nyberg J, Sandnabba K, Schalkwyk LC, Sluyter F (2004). Genetic and environmental (inter)actions in male mouse lines selected for aggressive and nonaggressive behavior. Genes Brain Behav. 3(2):101-9.
Stolerman IP, Chamberlain S, Bizarro L, Fernandes C, Schalkwyk LC (2004). The role of nicotinic receptor alpha 7 subunits in nicotine discrimination. Neuropharmacology. 46(3):363-71.
Fernandes C, Paya-Cano JL, Sluyter F, D’Souza U, Plomin R & Schalkwyk LC (2003). Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behavior. European Journal of Neuroscience 19(9): 2576-2582.
Flaherty L, Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Demant P, Doerge RW, Elliott RW, Farber CR, Flint J, Gershenfeld H, Gibson JP, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi F, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD,Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG and Zou F (2003) The nature and identification of quantitative trait loci: a community’s view. Nature Reviews Genetics 4(11):911-6.
Sluyter F, Schalkwyk LC (2003) Introduction to the special issue ’Aggression across species’ Behaviour Genetics 33: 457-460.
Nyberg J, Sandnabba K, Schalkwyk LC, Sluyter F (2004) Genetic and environmental (inter)actions in male mouse lines selected for aggressive and nonaggressive behavior. Genes Brain Behav. 3(2):101-9.
Mill J, Galsworthy MJ, Paya-Cano JL, Sluyter F, Schalkwyk LC, Plomin R, Asherson P (2002). Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity. Genes Brain And Behavior 1 (3): 166-173. tc=3
Klose J, Nock C, Hermann M, Stühler K, Marcus K, Blüggel, Krause E, Schalkwyk LC, Rastan S, Brown SDM, Büssow K, Himmelbauer H, Lehrach H (2002). Genetic analysis of the mouse proteome. Nature Genetics 30:385-393. tc=55
Schalkwyk LC, Cusack B, Dunkel I, Hopp M, Kramer M, Palczewski S, Piefke J, Scheel S, Weiher M, Wenske G, Lehrach H, Himmelbauer H (2001). Advanced integrated mouse YAC map including BAC framework. Genome Research 11: 2142-2150.
Gösele C, Hong L, Kreitler T, Rossmann M, Hieke B, Gross U, Kramer M, Himmelbauer H, Bihoreau MT, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC, Lindpaintner K, Ganten D, Lehrach H, Knoblauch M (2000). High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers. Genomics. 69(3):287-94.
Leong WL, Dobson MJ, Logsdon JM, Abdel-Majid RM, Schalkwyk LC, Guernsey DL and Neumann PE (2000). ETn insertion in the mouse Adcy1 gene: transcriptional and phylogenetic analyses. Mamm Genome 11(2):97-103.
Himmelbauer H, Schalkwyk LC and Lehrach H (2000). Interspersed repetitive sequence (IRS) -PCR for typing whole-genome radiation hybrid panels. Nucleic Acids Res 28(2):e7.
Knoblauch M, Gosele C, Zimdahl H, Hieke B Himmelbauer H, Schalkwyk LC, Lindpaintner K Ganten D, Lehrach H (2000). New tools for the high throughput characterization of rat genomic DNA samples. Journal Of Experimental Animal Science 41(1-2):35-37.
twentieth century publications
last updated: Tuesday, October 25, 2011