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Dr Leonard C Schalkwyk  PhD
Reader in Functional Genomics

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tel+44 (0) 207 848 0279
fax+44 (0) 207 848 0866
address

Institute of Psychiatry
Box  P082
De Crespigny Park
London
United Kingdom, SE5 8AF

location c110
MRC, SGDP Centre
departmentsSocial, Genetic and Developmental Psychiatry Centre (MRC)
alsoGENDEP

biography

Leo Schalkwyk is originally a microbiologist from Canada, and studied Microbiology at the University of Alberta in Edmonton, graduating in 1983. He completed his PhD in Biochemistry at Dalhousie University in 1991. His PhD work was on genome mapping of Haloferax, an archaeon from the Dead Sea, with Ford Doolittle.

Dr Schalkwyk worked in Hans Lehrach’s laboratory at the Imperial Cancer Research Fund laboratory in London and at the Max-Planck-Institut für molekulare Genetik in Berlin.

He has been at the SGDP Research Centre since the spring of 2000 where he works on functional genomics, identifying genes involved in behaviour in the mouse. His group studies phenotypes related to depression. They also have interests in developing technology related to DNA methylation, gene expression and bioinformatics.

teaching activities

SGDP summer school: Introduction to R 2011, 2012

publications

Bibliography with citation counts at ResearcherID
Google Scholar Profile


Malki K, Tosto MG, Jumabhoy I, Lourdusamy A, Sluyter F, Craig I, Uher R, McGuffin P, and Schalkwyk LC (2013). Integrative mouse and human mRNA studies using WGCNA nominates novel candidate genes involved in the pathogenesis of major depressive disorder. Pharmacogenomics14(16):1979-90.
Schughart K, Libert C, {SYSGENET consortium}, and Kas MJ (2013). Controlling complexity: the clinical relevance of mouse complex genetics. Eur J Hum Genet21(11):1191-6.
Powell TR, Schalkwyk LC, Heffernan AL, Breen G, Lawrence T, Price T, Farmer AE, Aitchison KJ, Craig IW, Danese A, Lewis C, McGuffin P, Uher R, Tansey KE, and D’Souza UM (2013). Tumor Necrosis Factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response. Eur Neuropsychopharmacol23(9):1105-14.
Powell TR, Tansey KE, Breen G, Farmer AE, Craig IW, Uher R, McGuffin P, D’Souza UM, and Schalkwyk LC (2013). ATP-binding cassette sub-family F member 1 (ABCF1) is identified as a putative therapeutic target of escitalopram in the inflammatory cytokine pathway. J Psychopharmacol27(7):609-15.
Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, and Mill J (2013). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Mol Psychiatry18(6):635-6.
Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, and Mill J (2013). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry.
Kõks S, Overall RW, Ivask M, Soomets U, Guha M, Vasar E, Fernandes C, and Schalkwyk LC (2013). Silencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage. Physiol Genomics45(5):182-90.
Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, and Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics14:293.
Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, and Tansey KE (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Transl Psychiatry3:e300.
Lill M, Kõks S, Soomets U, Schalkwyk LC, Fernandes C, Lutsar I, and Taba P (2013). Peripheral blood RNA gene expression profiling in patients with bacterial meningitis. Front Neurosci7:33.
Navarrete K, Pedroso I, De Jong S, Stefansson H, Steinberg S, Stefansson K, Ophoff RA, Schalkwyk LC, and Collier DA (2013). TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. Am J Med Genet B Neuropsychiatr Genet162B(1):1-16.
Malki K, Lourdusamy A, Binder E, Payá-Cano J, Sluyter F, Craig I, Keers R, McGuffin P, Uher R, and Schalkwyk LC (2012). Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression. Pharmacogenet Genomics22(11):765-76.
Powell TR, Schalkwyk LC, Heffernan AL, Breen G, Lawrence T, Price T, Farmer AE, Aitchison KJ, Craig IW, Danese A, Lewis C, McGuffin P, Uher R, Tansey KE, and D’Souza UM (2012). Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response. Eur Neuropsychopharmacol.
Navarrete K, Pedroso I, De Jong S, Stefansson H, Steinberg S, Stefansson K, Ophoff R, Schalkwyk LC, and Collier DA (2012). TCF4 (e2-2; ITF2): A Schizophrenia-Associated Gene With Pleiotropic Effects on Human Disease. AMERICAN JOURNAL OF MEDICAL GENETICS PART B.
Pidsley R, Fernandes C, Viana J, Paya-Cano JL, Liu L, Smith RG, Schalkwyk LC, and Mill J (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Mol Brain5:42.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, Al-Sarraj S, Dobson R, Schalkwyk LC, and Mill J (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biology13(6):R43.
Parsons MJ, Grimm C, Payá-Cano JL, Fernandes C, Lin L, Philip VM, Chesler EJ, Nietfeld W, Lehrach H, and Schalkwyk LC (2012). Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains. BMC Genomics13:476.
Kember RL, Dempster EL, Lee THA, Schalkwyk LC, Mill J, and Fernandes C (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. Brain Behav2:455-467.
Malki K, Campbell J, Davies M, Keers R, Uher R, Ward M, Payá-Cano J, Aitchinson KJ, Binder E, Sluyter F, Kuhn K, Selzer S, Craig I, McGuffin P, and Schalkwyk LC (2012). Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains. Proteomics12:2355-2365.
Keers R, Pedroso I, Breen G, Aitchison KJ, Nolan PM, Cichon S, Nothen MM, Rietschel M, Schalkwyk LC, and Fernandes C (2012). Reduced Anxiety and Depression-Like Behaviours in the Circadian Period Mutant Mouse Afterhours. Plos One7.
Jeffries AR, Perfect LW, Ledderose J, Schalkwyk LC, Bray NJ, Mill J, and Price J (2012). Stochastic Choice of Allelic Expression in Human Neural Stem Cells. Stem Cells30:1938-1947.
Binder E, Malki K, Payá-Cano JL, Fernandes C, Aitchison KJ, Mathe AA, Sluyter F, and Schalkwyk LC (2011). Antidepressants and the resilience to early-life stress in inbred mouse strains. Pharmacogenetics and Genomics21:779-789.
Malki K, Uher R, Payá-Cano J, Binder E, Rietschel M, Zobel A, Mors O, Hauser J, Henigsberg N, Jerman B, Souery D, Placentino A, Ng MY, Cohen-Woods S, Sluyter F, Farmer A, Aitchison KJ, Craig IW, Lewis CM, McGuffin P, and Schalkwyk LC (2011). Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants. Biological Psychiatry69:360-365.
Dempster E, Pidsley R, Schalkwyk L, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, Murray R, and Mill J (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Human Molecular Genetics20(24):4786-4796.
Kõks S, Soomets U, Plaas M, Terasmaa A, Noormets K, Tillmann V, Vasar E, Fernandes C, and Schalkwyk LC (2011). Hypothalamic gene expression profile indicates a reduction in G protein signaling in the Wfs1 mutant mice. Physiological Genomics43:1351-1358.
Sikk K, Kõks S, Soomets U, Schalkwyk LC, Fernandes C, Haldre S, Aquilonius S, and Taba P (2011). Peripheral blood RNA gene expression profiling in illicit methcathinone users reveals effect on immune system. Frontiers in Neurogenomics2(42).
Kember R, Fernandes C, Tunbridge E, Liu L, Payá-Cano J, Parsons M, and Schalkwyk L (2010). A B2 SINE insertion in the Comt1 gene (Comt1B2i) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains. Genes Brain and Behavior:925-932.
Docherty S, Davis O, Kovas Y, Meaburn E, Dale P, Petrill S, Schalkwyk L, and Plomin R (2010). A genome-wide association study identifies multiple loci associated with mathematics ability and disability. Genes Brain and Behavior:234-247.
Ronald A, Butcher LM, Docherty S, Davis OSP, Schalkwyk LC, Craig IW, and Plomin R (2010). A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples. Behavior Genetics40(1):31-45.
Davis OSP, Butcher LM, Docherty SJ, Meaburn EL, Curtis CJC, Simpson MA, Schalkwyk LC, and Plomin R (2010). A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Behavior Genetics40:759-767.
Meaburn E, Schalkwyk L, and Mill J (2010). Allele-specific methylation in the human genome Implications for genetic studies of complex disease. Epigenetics:578-582.
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, and Mill J (2010). Allelic Skewing of DNA Methylation Is Widespread across the Genome. American Journal of Human Genetics86(2):196-212.
Lad H, Liu L, Payá-Cano J, Parsons M, Kember R, Fernandes C, and Schalkwyk L (2010). Behavioural battery testing: Evaluation and behavioural outcomes in 8 inbred mouse strains. Physiology & Behavior:301-316.
Davies M, Meaburn E, and Schalkwyk L (2010). Gene set enrichment; a problem of pathways. Briefings in Functional Genomics9(5-6):385-390.
Sikk K, Kõks S, Soomets U, Schalkwyk L, Fernandes C, Haldre S, Aquilonius S, and Taba P (2010). Peripheral blood RNA gene expression profiling in illicit methcathinone users reveals effect on immune system. Movement Disorders:S226-S226.
Ronald A, Butcher LM, Docherty SJ, Davis OSP, Schalkwyk LC, Craig IW, and Plomin R (2010). Response to comment by Stuart Macgregor. Behavior Genetics40(1):48-48.
Kõks S, Velthut A, Sarapik A, Altmae S, Reinmaa E, Schalkwyk L, Fernandes C, Lad H, Soomets U, Jaakma U, and Salumets A (2010). The differential transcriptome and ontology profiles of floating and cumulus granulosa cells in stimulated human antral follicles. Molecular Human Reproduction:229-240.
Smith RG, Kember RL, Mill J, Fernandes C, Schalkwyk LC, Buxbaum JD, and Reichenberg A (2009). Advancing Paternal Age Is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model. Plos One4.
Meaburn EL, Fernandes C, Craig IW, Plomin R, and Schalkwyk LC (2009). Assessing Individual Differences in Genome-Wide Gene Expression in Human Whole Blood: Reliability Over Four Hours and Stability Over 10 Months. Twin Research and Human Genetics12(4):372-380.
Kas MJH, Gelegen C, Schalkwyk LC, and Collier DA (2009). Interspecies Comparisons of Functional Genetic Variations and Their Implications in Neuropsychiatry. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics150B(3):309-317.
Davis OSP, Plomin R, and Schalkwyk LC (2009). The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays. Bioinformatics25(2):281-283.
Kõks S, Soomets U, Payá-Cano JL, Fernandes C, Luuk H, Plaas M, Terasmaa A, Tillmann V, Noormets K, Vasar E, and Schalkwyk LC (2009). Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway. Physiological Genomics37(3):249-259.
Kõks S, Fernandes C, Kurrikoff K, Vasar E, and Schalkwyk LC (2008). Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice. Behavioural Brain Research188(1):62-70.
Meaburn EL, Harlaar N, Craig IW, Schalkwyk LC, and Plomin R (2008). Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children. Molecular Psychiatry13(7):729-740.
Parsons MJ, Grimm CH, Payá-Cano JL, Sugden K, Nietfeld W, Lehrach H, and Schalkwyk LC (2008). Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mammalian Genome19(7-8):552-560.
Docherty SJ, Butcher LM, Schalkwyk LC, and Plomin R (2007). Applicability of DNA pools on 500 KSNP microarrays for cost-effective initial screens in genomewide association studies. BMC Genomics8(1):214.
Sugden K, D’Souzal UM, Aitchison KJ, Schalkwyk LC, McGuffin P, Byers H, Campbell J, Hye A, and Pariante CM (2007). Gene expression analyses of mouse fibroblast cell line L929 after antidepressant treatment. European Neuropsychopharmacology17:S27-S28.
Kas MJH, Fernandes C, Schalkwyk LC, and Collier DA (2007). Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men. Molecular Psychiatry12(4):324-330.
Meaburn E, Harlaar N, Craig IW, Schalkwyk LC, and Plomin R (2007). Genomewide gene expression profiles as a biological basis for non-shared environment: MZ twins discordant for reading ability. Behavior Genetics37(6):776-776.
Schalkwyk LC, Fernandes C, Nash MW, Kurrikoff K, Vasar E, and Kõks S (2007). Interpretation of knockout experiments: the congenic footprint. Genes Brain and Behavior6(3):299-303.
Plomin R and Schalkwyk LC (2007). Microarrays. Developmental Science10(1):19-23.
Caspi A, Williams B, Kim-Cohen J, Craig IW, Milne BJ, Poulton R, Schalkwyk LC, Taylor A, Werts H, and Moffitt TE (2007). Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proceedings of the National Academy of Sciences of the United States of America104(47):18860-18865.
Lad HV, Liu L, Payá-Cano JL, Fernandes C, and Schalkwyk LC (2007). Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping. Mammalian Genome18(6-7):482-491.
Butcher LM, Meaburn E, Craig IW, Schalkwyk LC, and Plomin R (2006). A genomewide association scan for GE interplay in childhood. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics141B(7):O202.
Meaburn E, Butcher LM, Harlaar N, Curtis C, Craig IW, Schalkwyk LC, and Plomin R (2006). An association scan using pooled DNA and 100k SNPS identifies a ’SNP set’ for early reading. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics141B(7):703-704.
Huezo-Diaz P, Williamson R, Nash MW, Sim SC, Alhberg S, Hoda F, Rietschel M, Schmal C, Farmer A, Schulze T, Hauser J, Henigsberg N, Maier W, Zobel A, Larsen ER, Mors O, Mendelewicz J, Marusic A, Perez J, Schalkwyk L, McGuffin P, Craig I, Ingelman-Sundberg M, and Aitchison KJ (2006). CYP2D6 and CYP2C19 association data from GENDEP, a multicentre European study. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics141B(7):761-762.
D’Souza U, Sugden K, Aitchison KJ, Schalkwyk LC, McGuffin R, and Pariante M (2006). Depression: the GENDEP study. European Neuropsychopharmacology16:S187-S187.
D’Souza UM, Sugden K, Pariante CM, Byers H, Ward M, Schalkwyk LC, McGuffin P, and Aitchison KJ (2006). Effects of antidepressant treatment on gene expression in mouse cultured cells. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics141B(7):O195.
Meaburn E, Butcher LM, Schalkwyk LC, and Plomin R (2006). Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans. Nucleic Acids Research34(4).
Fernandes C, Hoyle E, Dempster E, Schalkwyk LC, and Collier DA (2006). Performance deficit of alpha 7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain and Behavior5(6):433-440.
Payá-Cano JL, Sluyter F, Mineur YS, Fernandes C, Crusio WE, and Schalkwyk LC (2006). Strain differences in susceptibility to unpredictable chronic mild stress as assessed by hippocampal gene expression profiling. European Neuropsychopharmacology16:S216-S217.
Binder E, Payá-Cano JL, Sluyter F, and Schalkwyk LC (2006). The effects of a selective serotonin reuptake inhibitor and a tricyclic antidepressant on the behaviour of chronically stressed 129SvemJ and C57BL/6J mice in the hole board and forced swim test. European Neuropsychopharmacology16:S258-S258.
Simpson CL, Knight J, Butcher LM, Hansen VK, Meaburn E, Schalkwyk LC, Craig IW, Powell JF, Sham PC, and Al-Chalabi A (2005). A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays. Nucleic Acids Research33(3).
Butcher LM, Meaburn E, Knight J, Sham PC, Schalkwyk LC, Craig IW, and Plomin R (2005). Allelotyping over 10,000 SNPs using DNA pools and microarrays nominates four SNPs associated with mild mental impairment. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics138B(1):19-19.
Galsworthy MJ, Payá-Cano JL, Liu L, Monleon S, Gregoryan G, Fernandes C, Schalkwyk LC, and Plomin R (2005). Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice. Behavior Genetics35(5):675-692.
Butcher LM, Meaburn E, Dale PS, Sham P, Schalkwyk LC, Craig IW, and Plomin R (2005). Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms. Molecular Psychiatry10(4):384-392.
Sugden K, D’Souza UM, McGuffin P, Schalkwyk LC, Aitchison KJ, and Pariante CM (2005). Gene expression analyses of a mouse fibroblast cell line after antidepressant treatment. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics138B(1):147-147.
Meaburn E, Butcher LM, Liu L, Fernandes C, Hansen V, Al-Chalabi A, Plomin R, Craig I, and Schalkwyk LC (2005). Genotyping DNA pools on microarrays: Tackling the QTL problem of large samples and large numbers of SNPs. Bmc Genomics6.
Meaburn EL, Butcher LM, Knight J, Craig I, Schalkwyk LC, and Plomin R (2005). QTLs for reading disability at 7 years: Genotyping pooled DNA on 100K SNP microarrays. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics138B(1):51-51.
Liu L, Fernandes C, Brookes K, Payá-Cano J, Asherson P, and Schalkwyk LC (2005). Selecting over-active extremes in outbred heterogeneous stock (HS) mice for gene expression profiling: nominating novel candidate genes for over-activity. European Neuropsychopharmacology15:S36-S37.
Butcher LM, Meaburn E, Knight J, Sham PC, Schalkwyk LC, Craig IW, and Plomin R (2005). SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. Human Molecular Genetics14(10):1315-1325.
Butcher LM, Meaburn E, Knight J, Sham PC, Schalkwyk LC, Craig IW, and Plomin R (2005). SNPs, microarrays, and pooled DNA: Identification of four loci associated with mild mental impairment in a sample of 6000 children. Behavior Genetics35(6):795-795.
Craig IW, Mill J, Craig GM, Loat C, and Schalkwyk LC (2004). Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes. European Journal of Human Genetics12(8):639-646.
Butcher LM, Meaburn E, Dale PS, Sham P, Schalkwyk L, and Plomin R (2004). Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single nucleotide polymorphisms. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics130B(1):58-58.
Fernandes C, Liu L, Payá-Cano JL, Gregorova S, Forejt J, and Schalkwyk LC (2004). Behavioral characterization of wild derived male mice (Mus musculus musculus) of the PWD/Ph inbred strain: High exploration compared to C57BL/6J. Behavior Genetics34(6):621-630.
Fernandes C, Liu L, Payá-Cano JL, Whatley SA, and Schalkwyk LC (2004). Correlating behaviour with gene expression: Identifying genes for anxiety and cognition in the mouse. Journal of Psychopharmacology18(3):A74-A74.
Meaburn EL, Butcher ML, Liu L, Fernandes C, Sham P, Plomin R, Craig I, and Schalkwyk L (2004). DNA pools on 10K genechips: Solving the QTL problem of large samples and large numbers of SNPS. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics130B(1):29-29.
Nyberg J, Sandnabba K, Schalkwyk L, and Sluyter F (2004). Genetic and environmental (inter)actions in male mouse lines selected for aggressive and nonaggressive behavior. Genes Brain and Behavior3(2):101-109.
Butcher LM, Meaburn E, Liu L, Fernandes C, Hill L, Al-Chalabi A, Plomin R, Schalkwyk L, and Craig IW (2004). Genotyping pooled DNA on microarrays: A systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits. Behavior Genetics34(5):549-555.
Fernandes C, Payá-Cano JL, Sluyter F, D’Souza U, Plomin R, and Schalkwyk LC (2004). Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour. European Journal of Neuroscience19(9):2576-2582.
Churchill G, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschnepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu WK, De Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jjepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusiss A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi ZH, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou SM, Sillanpaa MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, and others (2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits. NATURE GENETICS36:1133-1137.
Ben Abdelkhalek H, Beckers A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Muller I, Herrmann BG, Ceolin M, Rivera-Pomar R, and Gossler A (2004). The mouse homeobox gene Not is required for caudal notochord development and affected 1725 by the truncate mutation. Genes & Development18(14):1725-1736.
Stolerman IP, Chamberlain S, Bizarro L, Fernandes C, and Schalkwyk L (2004). The role of nicotinic receptor alpha 7 subunits in nicotine discrimination. Neuropharmacology46(3):363-371.
Meaburn E, Schalkwyk L, Craig I, and Plomin R (2003). A genome wide scan using 400 non-synonymous SNP markers in DNA pools identifies genes associated with language impairment in children. American Journal of Human Genetics73(5):1930.
Sluyter F and Schalkwyk LC (2003). Introduction to the special issue - Aggression across species. Behavior Genetics33(5):457-460.
Chamberlain S, Bizarro L, Fernandes C, Schalkwyk L, and Stolerman IP (2003). Nicotinic receptors containing the alpha7 subunit do not contribute to nicotine discrimination. Behavioural Pharmacology14:S60-S61.
Sluyter F and Schalkwyk LC (2003). Symposium: Using microarrays in the analysis of behavior. Behavior Genetics33(6):720-720.
Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, De Haan G, Demant P, Doerge RW, Elliott RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gu J, Gu WK, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FA, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O’Hara BR, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou SM, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, and Zou F (2003). The nature and identification of quantitative trait loci: a community’s view. NATURE REVIEWS GENETICS4:911-916.
Fernandes C, Payá-Cano J, Sluyter F, D’Souza U, Plomin R, and Schalkwyk LC (2003). The power of gene expression profiling and mouse models to unravel behavior. Behavior Genetics33(6):701-701.
Hill L, Meaburn E, Butcher LM, Schalkwyk L, Craig IW, and Plomin R (2002). A genome scan using non-synonymous SNPs in coding regions and general cognitive ability. American Journal of Medical Genetics114(7):P98.
Tandon K, Schalkwyk L, Patel M, Kinirons M, Kerwin R, McGuffin P, and Aitchison KJ (2002). An amino acid substitution (IIe109Val) in CYP2D6. European Neuropsychopharmacology12:S405-S405.
Tandon K, Schalkwyk L, Checkley S, Patel M, Kinirons M, Kerwin RW, McGuffin P, and Aitchison KJ (2002). CYP2D6 genotype and treatment with tricyclic antidepressants. American Journal of Medical Genetics114(7):P58.
Klose J, Nock C, Herrmann M, Stuhler K, Marcus K, Bluggel M, Krause E, Schalkwyk LC, Rastan S, Brown SDM, Bussow K, Himmelbauer H, and Lehrach H (2002). Genetic analysis of the mouse brain proteome. Nature Genetics30(4):385-393.
Mill J, Galsworthy MJ, Payá-Cano JL, Sluyter F, Schalkwyk LC, Plomin R, and Asherson P (2002). Home-cage activity in heterogeneous stock (HS) mice as a model of’ baseline activity. Genes Brain and Behavior1(3):166-173.
Butcher LM, Meaburn EL, Hill L, Plomin R, and Schalkwyk L (2002). How many non-synonymous SNPS are available on public databases?. American Journal of Medical Genetics114(7):O7.
Meaburn EK, Butcher LM, Schalkwyk L, Craig I, and Plomin R (2002). Localisation of quantitative trait loci responsible for the heritability of language impairment using DNA pooling. American Journal of Medical Genetics114(7):P176.
Galsworthy MJ, Payá-Cano JL, Liu L, Fernandes C, Schalkwyk L, and Plomin R (2002). The reliabilities, interrelationships and quantitative genetics of cognitive tasks in mus musculus: A study of 250 heterogeneous stock mice. Behavior Genetics32(6):465-465.
Schalkwyk LC, Cusack B, Dunkel I, Hopp M, Kramer M, Palczewski S, Piefke J, Scheel S, Weiher M, Wenske G, Lehrach H, and Himmelbauer H (2001). Advanced integrated mouse YAC map including BAC framework. Genome Research11(12):2142-2150.
Meaburn EL, Plomin R, and Schalkwyk L (2001). Single nucleotide polymorphism genotyping in DNA pools. American Journal of Human Genetics69(4):2088.
Leong WL, Dobson MJ, Logsdon JM, Abdel-Majid RM, Schalkwyk LC, Guernsey DL, and Neumann PE (2000). ETn insertion in the mouse Adcy1 gene: transcriptional and phylogenetic analyses. Mammalian Genome11(2):97-103.
Gosele C, Hong L, Kreitler T, Rossmann M, Hieke B, Gross U, Kramer M, Himmelbauer H, Bihoreau MT, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC, Lindpaintner K, Ganten D, Lehrach H, and Knoblauch M (2000). High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers. Genomics69(3):287-294.
Knoblauch M, Gosele C, Zimdahl H, Hieke B, Himmelbauer H, Schalkwyk LC, Lindpaintner K, Ganten D, and Lehrach H (2000). New tools for the high throughput characterization of rat genomic DNA samples. Journal of Experimental Animal Science41(1-2):35-37

twentieth century publications

last updated: Thursday, January 16, 2014