Professor Declan G Murphy MBBS, FRCPsych, MD (USA)
Professor
Lead investigator MRC UK A.I.M.S. program.
Lead Investigator Dept of Health ADHD and autism clinical research program.
R+D Lead National Division South London and Maudsley NHS Trust.
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| contact this person | |
| tel | 020 7848 0984 |
| fax | 020 7848 0650 |
| address | Institute of Psychiatry |
| location | M6.23 IOP |
| departments | Psychological Medicine and Psychiatry |
| also | Brain Maturation |
biography
Professor Murphy’s main research interest is in the biological determinants of brain development and ageing; and how abnormalities in this process lead to neuropsychiatric disorders.
He undertook his clinical training at the Maudsley Hopsital. His research training was firstly at the Institute of psychiatry (IOP); and then at the National Institute on Aging (National Institutes of Health, USA).
Following this (and in a never to be repeated moment of homesickness !) he returned to the UK to a research position at the IOP.
He is currently; 1) head of the section of brain maturation; 2) lead investigator on the MRC funded UK multicentre neuroimaging network for research in autism (MRC UK AIMS program); 3) lead investigator on a new Department of Health (UK) clinical research program for ADHD and autism; 4) R+D lead National Services in the South London and Maudsley NHS Foundation Trust; and 5) the clinical director for adult services for autism spectrum disorders and ADHD at the South London and Maudsley NHS Trust.
publications
Selected peer-reviewed publications 2000-2006 (in chronological order).
Explicit and Implicit neural mechanisms for processing of social information from facial expressions: a functional magnetic resonance imaging study. Critchley H, Daly E, Philips M, Brammer M, Bullmore, Williams S, van Amelsvoort T, Robertson D, David A, Murphy DGM. Human Brain Mapping 2000;9:93-105.
Structural Brain abnormalities associated with deletion at chromosome 22Q11. A quantitative neuroimaging study of Adults With Velo-Cardio-Facial Syndrome. Van Amelsvoort Th, Daly E, Robertson D, Suckling J, Ng G, Critchley H, Owen M Henry J, Murphy K, Murphy DGM. Br J Psychiatry, 2001, 178, 412-419.
The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. Critchley H, Daly E, , Bullmore E, Williams S, van Amelsvoort T, Robertson D, Rowe A, Phillips M, McAlonan G, Howlin P, Murphy DGM. Brain, Vol. 123, No. 11, 2203-2212, November 2000.
Prefrontal and medial temporal correlates of repetetive violence to self and others Critchley H, Simmons A, Daly E, Russell A, Van Amelsvoort Th, Robertson D, Glover A, Murphy DGM. Biological Psychiatry, 2000;47: 928-934.
Effects of Estrogen replacement therapy on human brain aging; an in vivo 1H MRS study Robertson D, Van Amelsvoort Th, Daly E, Simmons A, Whitehead M, Morris RG, Murphy DGM. Neurology, 2001, 57: 2114-2117.
Asperger Syndrome- a 1H Magnetic Resonance Spectroscopy Study of Brain. Murphy DGM, Critchley HD, Schmitz N, McAlonan G, Van Amelsvoort T, Robertson D, Daly E, Rowe A, Russell A, Simmons A, Murphy K, Howlin P. Arch Gen Psychiatry. 2002 Oct;59(10):885-91.
Effects of long-term estrogen replacement therapy on growth hormone respone to pyridostigmine in healthy postmenopausal women. Van Amelsvoort Th, Murphy DGM, Robertson D, Daly E, Whitehouse M, Abel K. Psychoneuroendocrinology. 2003 Jan;28(1):101-12.
An investigation of the neuropsychological profile in adults with velo-cardio-facial syndrome. Henry J, VanAmelsvoort Th, Morris R, Owen M, Murphy DGM, Murphy K. Neuropsychologia. 2002, 40 (5), 471-478.
Brain Anatomy and sensorimotor gating in autistic disorder: a quantitative study using MRI and prepulse inhibition of startle. McAlonan G, Daly E, Kumari V, Critchley H, Van Amelsvoort T, Suckling J, Simmons A, Sigmundsson T, Greenwood K, Russell A, Happe F, Howlin P, Murphy DGM. Brain, 2002, Vol 127, 1594-1606.
Impaired Olfactory Identification in Asperger Syndrome. Suzuki Y, Critchley H, Rowe A, Howlin P, Murphy DGM. The Journal of Neuropsychiatry and Clinical Neurosciences. 2003;15(1):105-7.
Effects of estrogen replacement therapy on Dopaminergic Responsivity in Postmenopausal Women – a preliminary study. Craig M, Cutter WJ, Wickham H, van Amelsvoort TAMJ, Rymer J, Whitehead M, Murphy DGM. Psychoneuroendocriology. 2004, 29, 1309-1316.
SPET imaging of central muscarinic receptors with (R,R,)[123I]-I-QNB: Methodological considerations. Norbury, R., Travis, M.J., Erlandsson, K., Waddington, W., Owens, J., Ell, P.J., and Murphy, D.G.M. Nuclear Medicine and Biology, 2004, 31, 583-590.
A neuropsychological investigation of male premutation carriers of fragile x syndrome. C. Moore, E Daly, N Schmitz, Tassone F, Tysoe C, Hagerman R, Hagerman P, Morris R.G. Murphy K.C. Murphy DGM. Neuropsychologia, 2004 Vol 42/14 pp 1934-1947.
People with learning disabilities in a low secure in-patient unit: comparison of offenders and non-offenders. Reed S, Russell A, Xenitidis K, Murphy DGM. Br J Psychiatry. 2004 Dec;185:499-504.
Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging study. van Amelsvoort T, Daly E, Henry J, Robertson D, Ng V, Owen M, Murphy KC, Murphy DGM. Arch Gen Psychiatry. 2004 Nov;61(11):1085-96.
The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy. Moore CJ, Daly EM, Tassone F, Tysoe C, Schmitz N, Ng V, Chitnis X, McGuire P, Suckling J, Davies KE, Hagerman RJ, Hagerman PJ, Murphy KC, Murphy DGM. Brain. 2004 Dec;127(Pt 12):2672-81.
The Women’s Health Initiative Memory Study; findings, and implications for treatment. Craig M, Maki M, Murphy DGM. Lancet Neurol 2005; 4; 190-94.
Cognitive deficits associated with schizophrenia in velo-cardi-facial-syndrome. Amelsvoort TvT, Henry J, Morris R, Owen M, Linszen D, Murphy K, Murphy D. Schizophrenia Research, 2004, 70(2-3), 223-32.
Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism. McAlonan GM, Cheung V, Cheung C, Suckling J, Lam GY, Tai KS, Yip L, Murphy DGM, Chua SE. Brain 2005 Feb;128(Pt 2):268-76.
Obsessions and compulsions in Asperger syndrome and high-functioning autism. Russell AJ, Mataix-Cols D, Anson M, Murphy DG. Br J Psychiatry. 2005 Jun;186:525-8.
In vivo imaging of muscarinic receptors in the ageing female brain with (R,R) [(123) I] - I -QNB and single photon emission tomography. Norbury R, Travis MJ, Erlandsson K, Waddington W, Owen J, Pimlott S, Ell PJ, Murphy DGM. Experimental Gerontology, 2005. 40 (3), 137-45.
Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo 1H-MRS study. Felix Beacher; Andy Simmons; Verinder Prasher; Claire Adams; Eileen Daly; Maria Luisa Margallo-Lana; Robin Morris; Simon Lovestone; Kieran Murphy; Declan GM Murphy. Arch Gen Psychiatry. 2005 Dec;62(12):1360-5.
Autistic-spectrum disorders: lessons from neuroimaging. Toal F, Murphy DG, Murphy KC. Br J Psychiatry. 2005 Nov;187:395-7.
Neural correlates of executive function in autistic spectrum disorders. Schmitz N, Rubia K, Daly E, Smith A, Williams S, Murphy DGM. Biol Psychiatry. 2006 Jan 1;59(1):7-16.
The influence of X Chromosome and Hormones on Human Brain Development: A Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy Study of Turner Syndrome. Cutter WJ, Daly EM, Robertson DM, Chitnis XA, van Amelsvoort TA, Simmons A, Ng VW, Williams BS, Shaw P, Conway GS, Skuse DH, Collier DA, Craig M, Murphy DG. Biol Psychiatry. 2006; 59: 273-282.
Neural correlates of executive function in autistic spectrum disorders. Schmitz N, Rubia K, Daly E, Smith A, Williams S, Murphy DGM. Biol Psychiatry. 2006 Jan 1;59(1):7-16.
Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger’s syndrome: an in vivo SPECT study. Murphy DG, Daly E, Schmitz N, Toal F, Murphy K, Curran S, Erlandsson K, Eersels J, Kerwin R, Ell P, Travis M. Am J Psychiatry. 2006 May;163(5):934-6.
Brain and behaviour in children with 22q11.2 deletion syndrome: a volumetric and voxel-based morphometry MRI study. Campbell LE, Daly E, Toal F, Stevens A, Azuma R, Catani M, Ng V, van Amelsvoort T, Chitnis X, Cutter W, Murphy DG, Murphy KC. Brain. 2006 May;129(Pt 5):1218-28.
An association analysis of candidate genes on chromosome 15 q11-13 and autism spectrum disorder. Curran S, Powell J, Neale BM, Dworzynski K, Li T, Murphy D, Bolton PF. Mol Psychiatry. 2006 Aug;11(8):709-13.
In Vivo 1H-Magnetic Resonance Spectroscopy Study of Amygdala-Hippocampal and Parietal Regions in Autism. Page L, Schmitz N, Simmons A, Daly E, Toal F, Deeley Q, Russell A, McAlanon G, Murphy DGM.
Am J Psychiatry. 2006 Dec;163(12):2189-92.
Processing facial emotions in adults with velo-cardio-facial syndrome: functional magnetic resonance imaging. VAN Amelsvoort T, Schmitz N, Daly E, Deeley Q, Critchley H, Henry J, Robertson D, Owen M, Murphy KC, Murphy DG. Br J Psychiatry. 2006 Dec;189:560-1
Facial emotion processing in criminal psychopathy: Preliminary functional magnetic resonance imaging study. Deeley Q, Daly E, Surguladze S, Tunstall N, Mezey G, Beer D, Ambikapathy A, Robertson D, Giampietro V, Brammer MJ, Clarke A, Dowsett J, Fahy T, Phillips ML, Murphy DG. Br J Psychiatry. 2006 Dec;189:533-9.
Neuropsychological functioning in adults with Asperger syndrome. Ambery FZ, Russell AJ, Perry K, Morris R, Murphy DG. Autism. 2006 Nov;10(6):551-64
An Event Related fMRI Study of Facial Emotion Processing in Aspergers Syndrome. Deeley Q, Daly E, Giampierto V, Brammer M, Toal F, Hallahan B, Robertson D, Curran S, Murphy DGM. Biol Psychiatry, 2006. In press.
last updated: Friday, June 22, 2007