Dr Gerome D Breen MSc PhD
Senior lecturer
Biomedical Research Centre Genetics Coordinator
 | |
| contact this person | |
| tel | 020 7848 0409 |
| fax | 0775 |
| address | Institute of Psychiatry |
| location | C222 MRC, SGDP Centre |
| departments | NIHR BRC for Mental Health Social, Genetic and Developmental Psychiatry Centre (MRC) |
| also | Molecular Genetic Studies Neuropsychiatric Genetics |
biography
Gerome Breen is a Senior Lecturer in the MRC Social Genetic and Developmental Psychiatry Research Centre at King’s College London.
He has published over 100 papers with a H-factor of 29 and his core publications have been on common mental disorders such as depression and manic depression. He and his team are currently working with collaborators on mood disorders in the form of GWAS, linkage and whole genome sequencing studies as well as methods for GWAS bioinformatics and pathway analyses of psychiatric disorders and miRNA in the CNS.
Gerome is currently a faculty member of the NIHR through involvement as genetics coordinator at the NIHR Biomedical Research Centre for Mental Health (IOP) and the South London and Maudsley NHS Trust. He was recently supported by MRC project grants, a Wellcome Trust Value in People award and a NARSAD Young Investigator Award.
An up-to-date paper list and citation metrics can be found on his ResearcherID page.
teaching activities
| Role | Course |
|---|---|
| Lecturer | Neuroscience » Masters (MSc) |
| Lecturer | Psychiatric Research » Masters (MSc) |
publications
2012
PGC MDD Group: A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2012.
Haddley K, Bubb VJ, Breen G, Parades-Esquivel UM, Quinn JP. Behavioural Genetics of the Serotonin Transporter. Curr Top Behav Neurosci. 2012.
Hing B, Davidson S, Lear M, Breen G, Quinn J, McGuffin P, et al. A Polymorphism Associated with Depressive Disorders Differentially Regulates Brain Derived Neurotrophic Factor Promoter IV Activity. Biol Psychiatry. 2012.
Pedroso I, Lourdusamy A, Rietschel M, Nöthen MM, Cichon S, McGuffin P, et al. Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes. Biol Psychiatry. 2012.
Perroud N, Uher R, Ng MY, Guipponi M, Hauser J, Henigsberg N, et al. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. Pharmacogenomics J. 2012;12(1):68-77.
Sullivan P, Investigators PG. Don’t give up on GWAS. Mol Psychiatry. 2012;17(1):2-3.
Vassos E, Steinberg S, Cichon S, Breen G, Sigurdsson E, Andreassen OA, et al. Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder. Biol Psychiatry. 2012.
2011
Belmonte Mahon, P., Pirooznia, M., Goes, F. S., Seifuddin, F., Steele, J., Lee, P. H., Huang, J., Hamshere, M. L., Depaulo, J. R., Kelsoe, J. R., Rietschel, M., Nöthen, M., Cichon, S., Gurling, H., Purcell, S., Smoller, J. W., Craddock, N., Schulze, T. G., McMahon, F. J., Potash, J. B., Zandi, P. P., & Bipolar Genome Study (BiGS) Consortium, T. e. W. T. C. C. C. B. D. G. 2011. Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet, 156B(3): 370-378.
Breen, G., Lewis, C. M., Vassos, E., Pergadia, M. L., Blackwood, D. H. R., Boomsma, D. I., Penninx, B., Sullivan, P. F., Pedroso, I., Collier, D., & McGuffin, P. 2011a. Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression. Nature Genetics, 43(1): 3-5.
Breen, G., Webb, B. T., Butler, A. W., van den Oord, E. J. C. G., Tozzi, F., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Cohen-Woods, S., Perry, J., Galwey, N. W., Upmanyu, R., Craig, I., Lewis, C. M., Ng, M., Brewster, S., Preisig, M., Rietschel, M., Jones, L., Knight, J., Rice, J., Muglia, P., Farmer, A. E., & McGuffin, P. 2011b. A Genome-Wide Significant Linkage for Severe Depression on Chromosome 3: The Depression Network Study. American Journal of Psychiatry, 168(8): 840-847.
Davidson, S., Lear, M., Shanley, L., Hing, B., Baizan-Edge, A., Herwig, A., Quinn, J. P., Breen, G., McGuffin, P., Starkey, A., Barrett, P., & MacKenzie, A. 2011a. Differential Activity by Polymorphic Variants of a Remote Enhancer that Supports Galanin Expression in the Hypothalamus and Amygdala: Implications for Obesity, Depression and Alcoholism. Neuropsychopharmacology, 36(11): 2211-2221.
Davidson, S., Lear, M., Shanley, L., Hing, B., Baizan-Edge, A., Herwig, A., Quinn, J. P., Breen, G., McGuffin, P., Starkey, A., Barrett, P., & Mackenzie, A. 2011b. Differential Activity by Polymorphic Variants of a Remote Enhancer that Supports Galanin Expression in the Hypothalamus and Amygdala: Implications for Obesity, Depression and Alcoholism. Neuropsychopharmacology.
Dow, D., Huxley-Jones, J., Hall, J., Francks, C., Maycox, P., Kew, J., Gloger, I., Mehta, N., Kelly, F., Muglia, P., Breen, G., Jugurnauth, S., Pederoso, I., St Clair, D., Rujescu, D., & Barnes, M. 2011. ADAMTSL3 as a candidate gene for schizophrenia: Gene sequencing and ultra-high density association analysis by imputation. Schizophrenia Research, 127(1-3): 28-34.
Jugurnauth, S. K., Chen, C. K., Barnes, M. R., Li, T., Lin, S. K., Liu, H. C., Collier, D. A., & Breen, G. 2011. A COMT gene haplotype associated with methamphetamine abuse. Pharmacogenet Genomics.
Knight, J., Barnes, M., Breen, G., & Weale, M. 2011. Using Functional Annotation for the Empirical Determination of Bayes Factors for Genome-Wide Association Study Analysis. Plos One, 6(4).
Kohli, M., Lucae, S., Saemann, P., Schmidt, M., Demirkan, A., Hek, K., Czamara, D., Alexander, M., Salyakina, D., Ripke, S., Hoehn, D., Specht, M., Menke, A., Hennings, J., Heck, A., Wolf, C., Ising, M., Schreiber, S., Czisch, M., Muller, M., Uhr, M., Bettecken, T., Becker, A., Schramm, J., Rietschel, M., Maier, W., Bradley, B., Ressler, K., Nothen, M., Cichon, S., Craig, I., Breen, G., Lewis, C., Hofman, A., Tiemeier, H., van Duijn, C., Holsboer, F., Muller-Myhsok, B., & Binder, E. 2011. The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression. Neuron, 70(2): 252-265.
Pedroso, I., & Breen, G. 2011. Gene set analysis and network analysis for genome-wide association studies. Cold Spring Harb Protoc, 2011(9).
Rivera, M., Cohen-Woods, S., Kapur, K., Breen, G., Ng, M. Y., Butler, A. W., Craddock, N., Gill, M., Korszun, A., Maier, W., Mors, O., Owen, M. J., Preisig, M., Bergmann, S., Tozzi, F., Rice, J., Rietschel, M., Rucker, J., Schosser, A., Aitchison, K. J., Uher, R., Craig, I. W., Lewis, C. M., Farmer, A. E., & McGuffin, P. 2011. Depressive disorder moderates the effect of the FTO gene on body mass index. Mol Psychiatry.
Schosser, A., Butler, A. W., Ising, M., Perroud, N., Uher, R., Ng, M. Y., Cohen-Woods, S., Craddock, N., Owen, M. J., Korszun, A., Jones, L., Jones, I., Gill, M., Rice, J. P., Maier, W., Mors, O., Rietschel, M., Lucae, S., Binder, E. B., Preisig, M., Perry, J., Tozzi, F., Muglia, P., Aitchison, K. J., Breen, G., Craig, I. W., Farmer, A. E., Mueller-Myhsok, B., McGuffin, P., & Lewis, C. M. 2011. Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression. Plos One, 6(7).
Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., Blackwood, D., Corvin, A., Flickinger, M., Guan, W., Mattingsdal, M., McQuillin, A., Kwan, P., Wienker, T. F., Daly, M., Dudbridge, F., Holmans, P. A., Lin, D., Burmeister, M., Greenwood, T. A., Hamshere, M. L., Muglia, P., Smith, E. N., Zandi, P. P., Nievergelt, C. M., McKinney, R., Shilling, P. D., Schork, N. J., Bloss, C. S., Foroud, T., Koller, D. L., Gershon, E. S., Liu, C., Badner, J. A., Scheftner, W. A., Lawson, W. B., Nwulia, E. A., Hipolito, M., Coryell, W., Rice, J., Byerley, W., McMahon, F. J., Schulze, T. G., Berrettini, W., Lohoff, F. W., Potash, J. B., Mahon, P. B., McInnis, M. G., Zöllner, S., Zhang, P., Craig, D. W., Szelinger, S., Barrett, T. B., Breuer, R., Meier, S., Strohmaier, J., Witt, S. H., Tozzi, F., Farmer, A., McGuffin, P., Strauss, J., Xu, W., Kennedy, J. L., Vincent, J. B., Matthews, K., Day, R., Ferreira, M. A., O’Dushlaine, C., Perlis, R., Raychaudhuri, S., Ruderfer, D., Hyoun, P. L., Smoller, J. W., Li, J., Absher, D., Thompson, R. C., Meng, F. G., Schatzberg, A. F., Bunney, W. E., Barchas, J. D., Jones, E. G., Watson, S. J., Myers, R. M., Akil, H., Boehnke, M., Chambert, K., Moran, J., Scolnick, E., Djurovic, S., Melle, I., Morken, G., Gill, M., Morris, D., Quinn, E., Mühleisen, T. W., Degenhardt, F. A., Mattheisen, M., Schumacher, J., Maier, W., Steffens, M., Propping, P., Nöthen, M. M., Anjorin, A., Bass, N., Gurling, H., Kandaswamy, R., Lawrence, J., McGhee, K., McIntosh, A., McLean, A. W., Muir, W. J., Pickard, B. S., Breen, G., St Clair, D., Caesar, S., Gordon-Smith, K., Jones, L., Fraser, C., Green, E. K., Grozeva, D., Jones, I. R., Kirov, G., Moskvina, V., Nikolov, I., O’Donovan, M. C., Owen, M. J., Collier, D. A., Elkin, A., Williamson, R., Young, A. H., Ferrier, I. N., Stefansson, K., Stefansson, H., Thornorgeirsson, T., Steinberg, S., Gustafsson, O., Bergen, S. E., Nimgaonkar, V., Hultman, C., Landén, M., Lichtenstein, P., Sullivan, P., Schalling, M., Osby, U., Backlund, L., Frisén, L., Langstrom, N., Jamain, S., Leboyer, M., Etain, B., Bellivier, F., Petursson, H., Sigur Sson, E., Müller-Mysok, B., Lucae, S., Schwarz, M., Schofield, P. R., Martin, N., Montgomery, G. W., Lathrop, M., Oskarsson, H., Bauer, M., Wright, A., Mitchell, P. B., Hautzinger, M., Reif, A., Kelsoe, J. R., Purcell, S. M., & Group, P. G. C. B. D. W. 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet.
2010
Xu XH, Breen G, Chen CK, Huang YS, Wu YY, Asherson P: Association study between a polymorphism at the 3 ’-untranslated region of CLOCK gene and attention deficit hyperactivity disorder. Behavioral and Brain Functions 2010; 6
Uher R, Perroud N, Ng MYM, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Zagar T, Czerski PM, Jerman B, Larsen ER, Schulze TG, Zobel A, Cohen-Woods S, Pirlo K, Butler AW, Muglia P, Barnes MR, Lathrop M, Farmer A, Breen G, Aitchison KJ, Craig I, Lewis CM, McGuffin P: Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project. American Journal of Psychiatry 2010; 167(5):555-564
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Guntert A, Proitsi P, Powell J, Causevic M, Killick R, Lunnon K, Lynham S, Broadstock M, Choudhry F, Howlett DR, Williams RJ, Sharp SI, Mitchelmore C, Tunnard C, Leung R, Foy C, O’Brien D, Breen G, Furney SJ, Ward M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Hodges A, Murphy DGM, Parkins S, Richardson JC, Resnick SM, Ferrucci L, Wong DF, Zhou Y, Muehlboeck S, Evans A, Francis PT, Spenger C, Lovestone S: Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease. Archives of General Psychiatry 2010; 67(7):739-748
Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, Weale ME, Schosser A, Paredes UM, Rivera M, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Aitchison KJ, Shi JX, Quinn JP, MacKenzie A, Vollenweider P, Waeber G, Heath S, Lathrop M, Muglia P, Barnes MR, Whittaker JC, Tozzi F, Holsboer F, Preisig M, Farmer AE, Breen G, Craig IW, McGuffin P: Genome-Wide Association Study of Major Recurrent Depression in the UK Population. American Journal of Psychiatry 2010; 167(8):949-957
Grozeva D, Kirov G, Ivanov D, Jones IR, Jones L, Green EK, St Clair DM, Young AH, Ferrier N, Farmer AE, McGuffin P, Holmans PA, Owen MJ, O’Donovan MC, Craddock N, Wellcome Trust Case C: Rare Copy Number Variants A Point of Rarity in Genetic Risk for Bipolar Disorder and Schizophrenia. Archives of General Psychiatry 2010; 67(4):318-327
Dixon CI, Morris HV, Breen G, Desrivieres S, Jugurnauth S, Steiner RC, Vallada H, Guindalini C, Laranjeira R, Messas G, Rosahl TW, Atack JR, Peden DR, Belelli D, Lambert JJ, King SL, Schumann G, Stephens DN: Cocaine effects on mouse incentive-learning and human addiction are linked to alpha 2 subunit-containing GABA(A) receptors. Proceedings of the National Academy of Sciences of the United States of America 2010; 107(5):2289-2294
Craddock N, Jones L, Jones IR, Kirov G, Green EK, Grozeva D, Moskvina V, Nikolov I, Hamshere ML, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Norton N, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P, Holmans PA, Donnelly P, Owen MJ, O’Donovan MC, Wtccc: Strong genetic evidence for a selective influence of GABA(A) receptors on a component of the bipolar disorder phenotype. Molecular Psychiatry 2010; 15(2):146-153
Craddock N, Hurles ME, Cardin N, et al.: Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010; 464(7289):713-U86
Campos-de-Sousa S, Guindalini C, Tondo L, Munro J, Osborne S, Floris G, Pedrazzoli M, Tufik S, Breen G, Collier D: Nuclear Receptor Rev-Erb-alpha Circadian Gene Variants and Lithium Carbonate Prophylaxis in Bipolar Affective Disorder. Journal of Biological Rhythms 2010; 25(2):132-137
Butler AW, Breen G, Tozzi F, Craddock N, Gill M, Korszun A, Maier W, Middleton LT, Mors O, Owen MJ, Perry J, Preisig M, Rice JP, Rietschel M, Jones L, Farmer AE, Lewis CM, McGuffin P: A Genomewide Linkage Study on Suicidality in Major Depressive Disorder Confirms Evidence for Linkage to 2p12. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 2010; 158B(8):1465-1473
Breen G: Practical informatics approaches to microsatellite and variable number tandem repeat analysis. Methods Mol Biol 2010; 628:181-94
Barnes MR, Breen G: A Short Primer on the Functional Analysis of Copy Number Variation for Biomedical Scientists. Methods in Molecular Biology - Genetic Variation: Methods and Protocols 2010:119-135
2009
Wain LV, Pedroso I, Landers JE, Breen G, Shaw CE, Leigh PN, Brown RH, Tobin MD, Al-Chalabi A: The Role of Copy Number Variation in Susceptibility to Amyotrophic Lateral Sclerosis: Genome-Wide Association Study and Comparison with Published Loci. Plos One 2009; 4(12)
Stokes PRA, Mehta MA, Curran HV, Breen G, Grasby PM: Can recreational doses of THC produce significant dopamine release in the human striatum? Neuroimage 2009; 48(1):186-190
Stokes PRA, Egerton A, Watson B, Reid A, Breen G, Lingford-Hughes A, Nutt DJ, Mehta MA: Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge. Neuroimage 2009; 52(4):1521-1527
Prata DP, Breen G, Osborne S, Munro J, St Clair D, Collier DA: An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis. Psychiatric Genetics 2009; 19(3):113-116
Perera G, Soremekun M, Breen G, Stewart R: The psychiatric case register: noble past, challenging present, but exciting future. British Journal of Psychiatry 2009; 195(3):191-193
Orozco G, Hinks A, Eyre S, Ke XY, Gibbons LJ, Bowes J, Flynn E, Martin P, Wilson AG, Bax DE, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Thomson W, Barton A, Worthington J, Wellcome Trust Case Control C, Consortium Y: Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Human Molecular Genetics 2009; 18(14):2693-2699
Newton-Cheh C, Johnson T, Gateva V, et al.: Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 2009; 41(6):666-676
Kovacs D, Vassos E, Li XH, Sun XL, Hu JM, Breen G, Tompa P, Collier DA, Li T: The androgen receptor gene polyglycine repeat polymorphism is associated with memory performance in healthy Chinese individuals. Psychoneuroendocrinology 2009; 34(6):947-952
Hamshere ML, Green EK, Jones IR, Jones L, Moskvina V, Kirov G, Grozeva D, Nikolov I, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P, Holmans PA, Owen MJ, O’Donovan MC, Craddock N, Wellcome Trust Case Control C: Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. British Journal of Psychiatry 2009; 195(1):23-29
Dehghan A, Yang Q, Peters A, Basu S, Bis JC, Rudnicka AR, Kavousi M, Chen MH, Baumert J, Lowe GDO, McKnight B, Tang WH, de Maat M, Larson MG, Eyhermendy S, McArdle WL, Lumley T, Pankow JS, Hofman A, Massaro JM, Rivadeneira F, Kolz M, Taylor KD, van Duijn CM, Kathiresan S, Illig T, Aulchenko YS, Volcik KA, Johnson AD, Uitterlinden AG, Tofler GH, Gieger C, Psaty BM, Couper DJ, Boerwinkle E, Koenig W, O’Donnell CJ, Witteman JC, Strachan DP, Smith NL, Folsom AR, Wellcome Trust Case Control C: Association of Novel Genetic Loci With Circulating Fibrinogen Levels A Genome-Wide Association Study in 6 Population-Based Cohorts. Circulation-Cardiovascular Genetics 2009; 2(2):125-U91
de Mooij-van Malsen A, van Lith HA, Oppelaar H, Hendriks J, de Wit M, Kostrzewa E, Breen G, Collier DA, Olivier B, Kas MJ: Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder. Biological Psychiatry 2009; 66(12):1123-1130
Bressan RA, Quarantini LC, Andreoli SB, Araujo C, Breen G, Guindalini C, Hoexter M, Jackowski AP, Jorge MR, Lacerda ALT, Lara DR, Malta S, Moriyama TS, Quintana MI, Ribeiro WS, Ruiz J, Schoedl AF, Shih MC, Figueira I, Koenen KC, Mello MF, Mari JJ: The posttraumatic stress disorder project in Brazil: neuropsychological, structural and molecular neuroimaging studies in victims of urban violence. Bmc Psychiatry 2009; 9
Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg JR, Hauser SL, Sexton D, Haines J, Sawcer S, Compston A, Wtccc: Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal of Human Genetics 2009; 17(10):1309-1313
Andreoli SB, Ribeiro WS, Quintana MI, Guindalini C, Breen G, Blay SL, Coutinho ESF, Harpham T, Jorge MR, Lara DR, Moriyama TS, Quarantini LC, Gadelha A, Vilete LMP, Yeh MSL, Prince M, Figueira I, Bressan RA, Mello MF, Dewey ME, Ferri CP, Mari JD: Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic survey. Bmc Psychiatry 2009; 9
Silberberg G, Levit A, Collier D, Clair DS, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R: Stargazin involvement with bipolar disorder and response to lithium treatment. Pharmacogenetics and Genomics 2008; 18(5):403-412
2008
Prata D, Breen G, Osborne S, Munro J, Clair DS, Collier D: Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 2008; 147B(6):914-917
Loos RJF, Lindgren CM, Li SX, et al.: Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 2008; 40(6):768-775
Karwautz A, de Sousa SC, Konrad A, Zesch HE, Wagner G, Zormann A, Wanner C, Breen G, Ray M, Kienbacher C, Natriashvili S, Collier DA, Wober C, Wober-Bingol C: Family-based association analysis of functional VNTR polymorphisms in the dopamine transporter gene in migraine with and without aura. Journal of Neural Transmission 2008; 115(1):91-95
Guindalini C, Laranjeira R, Collier D, Messas G, Vallada H, Breen G: Dopamine-beta hydroxylase polymorphism and cocaine addiction. Behavioral and Brain Functions 2008; 4
Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, Carter M, Watkins N, Ouwehand W, Lewis CM, Cardon L, Lobo A, Forbes A, Sanderson J, Jewell DP, Mansfield JC, Deloukas P, Mathew CG, Parkes M, Satsangi J, Wellcome Trust Case Control C: Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn’s disease. Nature Genetics 2008; 40(6):710-712
Ferreira MAR, O’Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, Clair DS, Robinson M, Van Beck M, Pereira ACP, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N, Wellcome Trust Case Control C: Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 2008; 40(9):1056-1058
Breen G, McGuffin P, Simmons A: Towards "Systems Psychiatry". Revista Brasileira De Psiquiatria 2008; 30(2):97-98
Breen G, Collier D, Craig I, Quinn J: Variable number tandem repeats as agents of functional regulation in the genome. Ieee Engineering in Medicine and Biology Magazine 2008; 27(2):103-+
Bilbao A, Parkitna JR, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Guindalini C, Vallada H, Laranjeira R, de Fonseca FR, Schumann G, Schutz G, Spanagel R: Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America 2008; 105(45):17549-17554
Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Plant D, Gibbons LJ, Wilson AG, Bax DE, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Worthington J, Wellcome Trust Case Control C, Year C, Consortium B: Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 2008; 40(10):1156-1159
Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Gibbons L, Plant D, Wilson AG, Marinou I, Morgan A, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Worthington J, Wellcome Trust Case Control C, Consortium Y: Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Human Molecular Genetics 2008; 17(15):2274-2279
2007
Roberts J, Scott AC, Howard MR, Breen G, Bubb VJ, Klenova E, Quinn JP: Differential regulation of the serotonin transporter gene by lithium is mediated by transcription factors, CCCTC binding protein and Y-box binding protein 1, through the polymorphic intron 2 variable number tandem repeat. Journal of Neuroscience 2007; 27(11):2793-2801
O’Gara C, Stapleton J, Sutherland G, Guindalini C, Neale B, Breen G, Ball D: Dopamine transporter polymorphisms are associated with short-term response to smoking cessation treatment. Pharmacogenetics and Genomics 2007; 17(1):61-67
Guindalini C, Collier D, Laranjeira R, Barrett TB, Kelsoe J, Castelo A, Vallada H, Breen G: Association analysis of GRK3 gene promoter variants in cocaine abuse. Psychiatric Genetics 2007; 17(4):239-242
de Sousa SC, Karwautz A, Wober C, Wagner G, Breen G, Zesch HE, Konrad A, Zormann A, Wanner C, Kienbacher C, Collier DA, Wober-Bingol C: A dopamine D4 receptor exon 3 VNTR allele protecting against migraine without aura. Annals of Neurology 2007; 61(6):574-578
Burton PR, Clayton DG, Cardon LR, et al.: Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007; 39(11):1329-37
Burton PR, Clayton DG, Cardon LR, et al.: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447(7145):661-678
2006
Prata DP, Breen G, Munro J, Sinclair M, Osborne S, Li T, Kerwin R, Clair DS, Collier DA: Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. Psychiatric Genetics 2006; 16(6):229-230
Nishiguchi N, Breen G, Russ C, St Clair D, Collier D: Association analysis of the glycogen synthase kinase-3 beta gene in bipolar disorder. Neuroscience Letters 2006; 394(3):243-245
Michelon L, Meira-Lima I, Cordeiro Q, Miguita K, Breen G, Collier D, Vallada H: Association study of the INPP1, 5HTT, BDNF, AP-2 beta and GSK-3 beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. Neuroscience Letters 2006; 403(3):288-293
Guindalini C, Vallada H, Breen G, Laranjeira R: Concurrent crack and powder cocaine users from Sao Paulo: Do they represent a different group? Bmc Public Health 2006; 6
Guindalini C, Howard M, Haddley K, Laranjeira R, Collier D, Ammar N, Craig I, O’Gara C, Bubb VJ, Greenwood T, Kelsoe J, Asherson P, Murray RM, Castelo A, Quinn JP, Vallada H, Breen G: A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proceedings of the National Academy of Sciences of the United States of America 2006; 103(12):4552-4557
Flomen RH, Collier DA, Osborne S, Munro J, Breen G, St Clair D, Makoff AJ: Association study of CHRFAM7A copy number and 2bp deletion polymorphisms with schizophrenia and bipolar affective disorder. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 2006; 141B(6):571-575
Brookes KJ, Mill J, Guindalini C, Curran S, Xu XH, Knight J, Chen CK, Huang YS, Sethna V, Taylor E, Chen W, Breen G, Asherson P: A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Archives of General Psychiatry 2006; 63(1):74-81
Breen G, Prata D, Osborne S, Munro J, Sinclair M, Li T, Staddon S, Dempster D, Sainz R, Arroyo B, Kerwin RW, St Clair D, Collier D: Association of the dysbindin gene with bipolar affective disorder. American Journal of Psychiatry 2006; 163(9):1636-1638
2005
Neves-Pereira M, Cheung J, Pasdar A, Zhang F, Breen G, Yates P, Sinclair M, Crombie C, Walker N, St Clair DM: BDNF gene is a risk factor for schizophrenia in a Scottish population. Molecular Psychiatry 2005; 10(2):208-212
McGuffin P, Knight J, Breen G, Brewster S, Boyd PR, Craddock N, Gill M, Korszun A, Maier W, Middleton L, Mors O, Owen MJ, Perry J, Preisig M, Reich T, Rice J, Rietschel M, Jones L, Sham P, Farmer AE: Whole genome linkage scan of recurrent depressive disorder from the depression network study. Human Molecular Genetics 2005; 14(22):3337-3345
Guindalini C, Scivoletto S, Ferreira RGM, Breen G, Zilberman M, Peluso MA, Zatz M: Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. American Journal of Psychiatry 2005; 162(5):1005-1007
Guindalini C, O’Gara C, Laranjeira R, Collier D, Castelo A, Vallada H, Breen G: A GSTP1 functional variant associated with cocaine dependence in a Brazilian population. Pharmacogenetics and Genomics 2005; 15(12):891-893
2004
Farmer A, Breen G, Brewster S, Craddock N, Gill M, Korszun A, Maier W, Middleton L, Mors O, Owen M, Perry J, Preisig M, Rietschel M, Reich T, Jones L, Jones I, McGuffin P: The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study. BMC Psychiatry 2004; 4:42
Breen G, Harwood AJ, Gregory K, Sinclair M, Collier D, St Clair D, Williams RSB: Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients. Bipolar Disorders 2004; 6(2):156-161
2003
Liu WQ, Breen G, Zhang JG, Li S, Gu NF, Feng GY, Bai SC, Shen T, Yu A, Xue H, St Clair D, He L: Association of APOE gene with schizophrenia in Chinese: a possible risk factor in times of malnutrition. Schizophrenia Research 2003; 62(3):225-230
Deary IJ, Whalley LJ, St Clair D, Breen G, Leaper S, Lemmon H, Hayward C, Starr JM: The influence of the epsilon 4 allele of the apolipoprotein E gene on childhood IQ, nonverbal reasoning in old age, and lifetime cognitive change. Intelligence 2003; 31(1):85-92
2002
Fan JB, Tang JX, Gu NF, Feng GY, Zou FG, Xing YL, Shi JG, Zhao SM, Zhu SM, Ji LP, Sun WW, Zheng YL, Liu WQ, Breen G, Clair DS, He L: A family-based and case-control association study of the NOTCH4 gene and schizophrenia. Molecular Psychiatry 2002; 7(1):100-103
Fan JB, Chen WY, Tang JX, Li S, Gu NF, Feng GY, Breen G, St Clair D, He L: Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population. Molecular Psychiatry 2002; 7(5):446-447
Breen G, Collier D: The Tower of Babel? An assessment of the development and state of genetic and SNP technologies. Psychiatric Genetics 2002; 12(2):59-61
Breen G: Novel and alternate SNP and genetic technologies. Psychiatric Genetics 2002; 12(2):83-88
2001
Zhang JG, Yang JG, Lin ZX, He L, Feng GY, Ma XY, Wang CF, Lu PF, Song SB, Dong XZ, St Clair D, Breen G: Apolipoprotein E epsilon 4 allele is a risk factor for late-onset Alzheimer’s disease and vascular dementia in Han Chinese. International Journal of Geriatric Psychiatry 2001; 16(4):438-439
Yang JD, Feng GY, Zhang J, Hui Z, Breen G, Clair DS, He L: Is ApoE gene a risk factor for vascular dementia in Han Chinese? International Journal of Molecular Medicine 2001; 7(2):217-219
Maude S, Curtin J, Breen G, Collier D, Russell G, Shaw D, St Clair D: The-141C Ins/Del polymorphism of the dopamine D2 receptor gene is not associated with either migraine or Parkinson’s disease. Psychiatric Genetics 2001; 11(1):49-52
MacLeod MJ, De Lange RP, Breen G, Meiklejohn D, Lemmon H, St Clair D: Lack of association between apolipoprotein E genoype and ischaemic stroke in a Scottish population. European Journal of Clinical Investigation 2001; 31(7):570-573
2000
Yang JD, Feng GY, Zhang J, Lin ZX, Shen T, Breen G, St Clair D, He L: Association between angiotensin-converting enzyme gene and late onset Alzheimer’s disease in Han Chinese. Neuroscience Letters 2000; 295(1-2):41-44
Wang HY, Zhang FC, Gao JJ, Fan JB, Liu P, Zheng ZJ, Xi H, Sun Y, Gao XC, Huang TZ, Ke ZJ, Guo GR, Feng GY, Breen G, St Clair D, He L: Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China. Molecular Psychiatry 2000; 5(4):363-368
Feuk L, Prince JA, Breen G, Emahazion T, Carothers A, Clair DS, Brookes AJ: Apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer’s disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. Human Genetics 2000; 107(4):391-396
Breen G, Harold D, Ralston S, Shaw D, Clair DS: Determining SNP allele frequencies in DNA pools. Biotechniques 2000; 28(3):464-+
1999
Liu WQ, Gu NF, Feng GY, Li S, Bai SC, Zhang JG, Shen T, Xue H, Breen G, St Clair D, He L: Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. Pharmacogenetics 1999; 9(4):491-495
Li T, Breen G, Brown J, Liu X, Murray RM, Shaw DJ, Sham PC, St Clair D, Collier DA: No evidence of linkage disequilibrium between a CAG repeat in the SCA1 gene and schizophrenia in Caucasian and Chinese schizophrenic subjects. Psychiatric Genetics 1999; 9(3):123-127
He L, Li T, Melville C, Liu S, Feng GY, Gu NF, Fox H, Shaw D, Breen G, Liu XH, Sham P, Brown J, Collier D, St Clair D: 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations. American Journal of Medical Genetics 1999; 88(1):95-98
Dahiyat M, Cumming A, Harrington C, Wischik C, Xuereb J, Corrigan F, Breen G, Shaw D, St Clair D: Association between Alzheimer’s disease and the NOS3 gene. Annals of Neurology 1999; 46(4):664-667
Breen G, Sham P, Li T, Shaw D, Collier DA, St Clair D: Accuracy and sensitivity of DNA pooling with microsatellite repeats using capillary electrophoresis. Molecular and Cellular Probes 1999; 13(5):359-365
Breen G, Fox H, Glen I, Collier D, Shaw D, St Clair D: Association study of the CACN1A4 (SCA6) triplet repeat and schizophrenia. Psychiatric Genetics 1999; 9(2):111-113
Breen G, Brown J, Maude S, Fox H, Collier D, Li T, Arranz M, Shaw D, St Clair D: -141 C Del/Ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population. American Journal of Medical Genetics 1999; 88(4):407-410
last updated: Monday, June 11, 2012