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Dr Sabine Landau  PhD
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tel020 7848 0313
fax0207 848 0281
address

Institute of Psychiatry
Box  P020
De Crespigny Park
London
United Kingdom, SE5 8AF

location S2.06
South Wing
departmentsBiostatistics
alsoClinical Trials Unit

biography

After graduating with a "Diplom in Statistik" at the University of Dortmund, Germany (1992) I started working as a Scientific Officer in the Statistics Department at the Institute of Arable Crop Research Rothamsted, Harpenden. This led to my PhD research (1994-1996) jointly at Rothamsted and the University of Nottingham, Department of Physiology and Environmental Science on modelling crop yields.

I joined the Institute of Psychiatry, London in 1997 as Lecturer in Biostatistics (1997-2003) progressing to Senior Lecturer in Biostatistics (2003-2007) in the Department of Biostatistics and Computing. I was appointed Reader in 2007. I became acting and later full Head of the Biostatistics Department in 2005-2009. During this time, for a period (2008-2009), I also headed the local Mental Health & Neurosciences Clinical Trials Unit.

I am on sabbatical at the University of Cambridge MRC Biostatistics Unit and the University of Manchester, Health Methodology Research Group until December 2010.

activities and interests

Most of my work is concerned with substantive applications of statistical methododology to answer questions posed in mental health research studies. I have previously carried out methodological research in the areas of spatial statistics as applied in neuropathology and cluster analysis.

I am generally interested in obtaining valid statistical inferences when not all process variables can be observed (latent variables or random effects) with the ultimate aim of making statements about causal population parameters.

More recently I have become focused on the statistical design and analysis of randomised trials of complex interventions. Many behavioural interventions are complex in that they consist of several active ingredients and imply mechanisms of action that involve treatment effects on clinical outcomes operating via intermediate outcomes. Key methodological issues in the evaluation of such interventions are noncompliance, mediators subject to hidden confounding, measurement error and missing values.

I am a member of the UK Mental Health Research Network (MHRN)-funded Methodology Research Group and the Royal Statistical Society General Applications (GAS) committee.

teaching activities

Biostatistics courses taught as part of IOPs general programmes on Behavioural Research Methodology

Introduction to Stata

Statistical analysis of Longitudinal and Clustered Data using Stata

Introduction to Missing Data

Meta-analysis using Stata

Introduction to Causal Inference

External courses

Current Issues in Design and Analysis of Mental Health Trials, MHRN Conference Nottingham, 2009

Missing Data in Mental Health Research: A Practical Approach using Stata, MRC BSU Cambridge, 2010

publications

(1) Statistical Methodology and Education (selected)

Everitt B.S., Landau S. and Leese M. (2001) Cluster Analysis, 4th edition, Arnold: London.

Landau S. (2002). Using survival analysis in psychology. Understanding Statistics, 1 (4): 233-269.

Landau S. and Everitt B.S. (2003) A Handbook of Statistical Analysis using SPSS, CRC/Chapman and Hall: Boca Raton, Florida.

Landau S, Wright I.C. and Bullmore E.T. (2004). Tests for a difference in timing of physiological response between two brain regions measured by using functional magnetic resonance imaging. Applied Statistics, 53 (1): 63-82.

Landau S., Rabe-Hesketh S. and Everall I. (2004). Nonparametric one-way analysis of variance of replicated bivariate spatial point patterns. Biometrical Journal, 46 (1): 19-34.

McKenzie N., Landau S., Kapur N., Meehan J., Robinson J., Bickley H., Parsons R. and Appleby L. (2005). Clustering of suicides among people with mental illness. British Journal of Psychiatry 187: 476-480.

Leese M. and Landau S. (2006). Model-based clustering in S-PLUS. Journal of Methods in Psychiatric Research 15 (3): 146-156.

Landau S. and Everall I.P. (2008). Nonparametric bootstrap for K-functions arising from mixed-effects models with applications in neuropathology, Statistica Sinica 4: 1375-1393.

Campbell D.C., Sham P.C., Knight, J., Wickham H. and Landau S. (2010) GELE - software for generating liability distributions for pedigrees conditional on their observed disease states and covariates, Genetic Epidemiology 34: 159-179.

(2) Substantive Research (recent)

Harland R., Antonova E., Owen G.S., Broome M., Landau S., Deeley Q. and Murray R. (2009). A study of psychiatrists’s concept of mental illness, Psychological Medicine 39: 967-976.

Eranti S., Mogg A., Landau S., Pluck G. and McLoughlin D. (2009). Methohexitone, propofol and etomidate in electroconvulsive therapy for depression: a naturalistic comparison study. Journal of Affective Disorders 113: 165-171.

Uher R., Maier W., Hauser J., Marusic A., Schmael C., Mors O, Henigsberg N., Souery O., Placentino A., Rietschel M., Zobel A., Dmitrzak-Weglarz M., Petrovic A., Jorgensen L., Kalember P., Giovannini C., Barreto M., Elkin A., Landau S., Farmer A., Aitchison K.J. and McGuffin P. (2009) Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. British Journal of Psychiatry 194: 252-259.

Stefanopoulou E., Andiappan M., Landau S., Geddes J., Goodwin G. and S Frangou (2009) Cognitive functioning in patients with affective disorders and schizophrenia: A meta-analysis. International Review of Psychiatry 21(5): 1-21.

Moss-Morris R., Dennison L., Yardley L., Landau S., Roche S., McCrone P. and Chalder T. (2009) Protocol for the saMS trial (supportive adjustment for multiple sclerosis): a randomized controlled trial comparing cognitive behavioral therapy to supportive listening adjustment to multiple sclerosis. BMC Neurology 9: 45.

Wykes T., Reeder C., Landau S., Mattiason P., Haworth E. and Hutchinson C. (2009). Does age matter? Effects of cognitive rehabilitation across the age span. Schizophrenia Research 113: 252-258.

Demjaha A., Morgan K., Morgan C., Landau S., Dean K., Reichenberg A., Sham P., Fearon P., Hutchinson G., Jones P.B., Murray R.M. and Dazzan P. (2009) Combining dimensional and categorical presentation of psychosis: the way forward for DSM-V and ICD-11? Psychological Medicine 39: 1943-1955.

Charlton R.A., Landau S., Schiavone F., Barrick T.R., Clark C.A., Markus H.S. and Morris R.G. (2010). Up the Garden Path: A critique of Penke and Deary (2009) and further exploration concerning the Charlton et al (2008) path analysis relating loss of white matter integrity to cognition in normal aging. Neuropsychology of Ageing 31: 1661-1666.

Scott S., Sylva K., Doolan M., Price J., Jacobs B., Crook C. and Landau S. (2010) Randomised controlled trial of parent groups for child antisocial behaviour targeting multiple risk factors: the SPOKES project. Journal of Child Psychology and Psychiatry 51: 48-57.

Fear N.T., Jones M., Murphy D., Hull L., Iversen A.C., Coker B., Machell L., Sundin J., Woodhead C., Jones N., Greenberg N., Landau S., Dandeker C., Rona R.J., Hotopf M. and Wessely S. (2010). What are the consequences of deployment to Iraq and Afghanistan on the mental health of the UK armed forces? A cohort study. Lancet 375: 1783-1797.

Peters E., Landau S., McCrone P., Cooke M., Fisher P., Steel C., Evans R., Carswell K., Dawson K., Williams S., Howard A. and Kuipers E. (2010). A Randomised Controlled Trial of Cognitive Behaviour Therapy for Psychosis in a routine clinical service: looking beyond the PANSS. Acta Scandinvia Psychiatrica, in press

Bithell A., Hsu T., Kandanearatchi A., Landau S., Everall I.P., Tsuang M.P., Chana G. and Williams B.P. (2010). Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, in altered in individuals with bipolar disorder. Plos One 5: e10392.

Gafoor R., Landau S., Craig T.K.J., Power P. and McGuire P. (2010) ESQUIRE trial: Efficacy and side effects of Quetiapine versus Risperidone in first episode Schizophrenia. Journal of Clinical Psychopharmacology, in press

Nieto-Hernandez R., Williams J., Cleare A.J., Landau S., Wessely S. and Rubin G.J. (2010) Can exposure to Terrestrial Trunked Radio (TETRA) signals cause symptoms? A randomized double blind provocation study. Environmental Health Perspectives, in press

Hurt C.S., Thomas B.A., Burn D.J., Hindle J.V., Landau S., Samuel M., Wilson K.C.M. and Brown R. (2010) Coping in Parkinson’s disease: An examination of the Coping Inventory for Stressful Situations, International Journal of Geriatric Psychiatry, in press


last updated: Monday, October 25, 2010