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Dr Oliver D Howes  BM BCh MA MRCPsych PhD DM
Senior lecturer
Honorary consultant psychiatrist

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tel0207 848 0080

Institute of Psychiatry
Box  P067
De Crespigny Park
United Kingdom, SE5 8AF

location 6th floor
Main Wing
departmentsPsychological Medicine
Psychosis Studies
alsoNeurochemical Imaging and Psychiatry
Schizophrenia, Imaging and Therapeutics
Section of Neuroimaging


Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis.

Fusar-Poli P, Howes OD, Allen P, Broome M, Valli I, Asselin MC, Montgomery AJ, Grasby PM, McGuire P.

Mol Psychiatry. 2009 Dec 1

The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function.

Egerton A, Demjaha A, McGuire P, Mehta MA, Howes OD.

Neuroimage. 2010 Apr 1;50(2):524-31.

Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study.

Egerton A, Shotbolt JP, Stokes PR, Hirani E, Ahmad R, Lappin JM, Reeves SJ, Mehta MA, Howes OD, Grasby PM.

Neuroimage. 2010 Mar;50(1):260-6.

Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: reproducibility in tracer characteristics and characterization of extrastriatal binding.

Egerton A, Hirani E, Ahmad R, Turton DR, Brickute D, Rosso L, Howes OD, Luthra SK, Grasby PM.

Synapse. 2010 Apr;64(4):301-12.

Impaired verbal self-monitoring in individuals at high risk of psychosis.

Johns LC, Allen P, Valli I, Winton-Brown T, Broome M, Woolley J, Tabraham P, Day F, Howes O, Wykes T, McGuire P.

Psychol Med. 2009 Dec 2:1-10.

The dopamine hypothesis of schizophrenia: version III--the final common pathway.

Howes OD, Kapur S.

Schizophr Bull. 2009 May;35(3):549-62.

Functionally defined regions may aid interpretation of striatal dopamine elevation in schizophrenia.

Egerton A, McGuire PK, Howes OD.

Schizophr Res. 2009 Apr;109(1-3):200.

Elevated striatal dopamine function linked to prodromal signs of schizophrenia.

Howes OD, Montgomery AJ, Asselin MC, Murray RM, Valli I, Tabraham P, Bramon-Bosch E, Valmaggia L, Johns L, Broome M, McGuire PK, Grasby PM.

Arch Gen Psychiatry. 2009 Jan;66(1):13-20.

Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia.

Prata DP, Mechelli A, Fu CH, Picchioni M, Kane F, Kalidindi S, McDonald C, Howes O, Kravariti E, Demjaha A, Toulopoulou T, Diforti M, Murray RM, Collier DA, McGuire PK.

Biol Psychiatry. 2009 Mar 15;65(6):473-80. Epub 2008 Dec 3.

Longitudinal PET imaging in a patient with schizophrenia did not show marked changes in dopaminergic function with relapse of psychosis.

Valli I, Howes O, Tyrer P, McGuire P, Grasby PM.

Am J Psychiatry. 2008 Dec;165(12):1613-4. No abstract available.

Multimodal functional imaging investigation before and after the onset of psychosis.

Fusar-Poli P, Howes O, Valli I, Allen P, Broome M, Grasby P, McGuire P.

Int J Neuropsychopharmacol. 2009 May;12(4):579-81

Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging.

Bose SK, Turkheimer FE, Howes OD, Mehta MA, Cunliffe R, Stokes PR, Grasby PM. Schizophr Res. 2008 Dec;106(2-3):148-55.

Understanding pathophysiology is crucial in linking clinical staging to targeted therapeutics.

Howes OD, McGuire PK, Kapur S.

World Psychiatry. 2008 Oct;7(3):162-3.

’Truman’ signs and vulnerability to psychosis.

Fusar-Poli P, Howes O, Valmaggia L, McGuire P.

Br J Psychiatry. 2008 Aug;193(2):168.

McGuire P, Howes OD, Stone J, Fusar-Poli P.
Functional neuroimaging in schizophrenia: diagnosis and drug discovery.
Trends Pharmacol Sci. 2008 Feb;29(2):91-8.

Bramon E, Shaikh M, Broome M, Lappin J, Bergé D, Day F, Woolley J, Tabraham P, Madre M, Johns L, Howes O, Valmaggia L, Pérez V, Sham P, Murray RM, McGuire P.
Abnormal P300 in people with high risk of developing psychosis.
Neuroimage. 2008 Jan 4

Howes OD, Montgomery AJ, Asselin MC, Murray RM, Grasby PM, McGuire PK.
Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis.
Br J Psychiatry, 2007 Dec;51:s13-8.

Howes OD, Weinstein S, Tabraham P, Valmaggia L, Broome M, McGuire P. Street slang and schizophrenia.
British Medical Journal, 2007. Dec 22; 335.

Howes OD, Wheeler MJ, Pilowsky LS, Landau S, Murray RM, Smith S.
Sexual function and gonadal hormones in patients taking antipsychotic treatment for schizophrenia or schizoaffective disorder.
J Clin Psychiatry. 2007 Mar;68(3):361-7.

Howes,O.D., Montgomery,A.J., Asselin,M.C., Murray,R.M., McGuire,P.K. & Grasby,P.M. The pre-synaptic dopaminergic system before and after the onset of psychosis: initial results from and ongoing [18F] fluoro-dopa PET study.
Schizophr.Res 81(S1), 14. 2006.

Howes OD, Smith S, Gaughran FP, Amiel SA, Murray RM, Pilowsky LS.
The relationship between prolactin levels and glucose homeostasis in antipsychotic-treated schizophrenic patients.
J Clin Psychopharmacol. 2006 Dec;26(6):629-31.

Howes OD.Compulsions in depression: stalking by text message.
Am J Psychiatry. 2006 Sep;163(9):1642.

Howes OD, Smith S, Aitchison KJ. Prolactin levels and erectile function in patients treated with risperidone.
J Clin Psychopharmacol. 2005 Aug;25(4):393-4.

Howes OD, Wheeler MJ, Meaney AM, O’Keane V, Fogelman I, Blake G, Murray RM, Smith S.
Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment.
J Clin Psychopharmacol. 2005 Jun;25(3):259-61.

Gaughran F, Howes OD, Chrisman L, Vincent A.
Serum glutamic acid decarboxylase 65 antibody levels in people with schizophrenia and their families.
Schizophr Res. 2005 Mar 1;73(2-3):379-81.

Howes OD, Gaughran FP, Amiel SA, Murray RM, Pilowsky LS. The effect of clozapine on factors controlling glucose homeostasis.
J Clin Psychiatry. 2004 Oct;65(10):1352-5.

Howes OD, Smith S, Aitchison KJ. Hyperprolactinaemia and antipsychotic therapy in schizophrenia.
Curr Med Res Opin. 2004 Oct;20(10):1649.

Howes OD, Rifkin L. Diabetic keto-acidotic (DKA) coma following olanzapine initiation in a previously euglycaemic woman and successful continued therapy with olanzapine.
J Psychopharmacol. 2004 Sep;18(3):435-7.

Meaney AM, Smith S, Howes OD, O’Brien M, Murray RM, O’Keane V.
Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia.
Br J Psychiatry. 2004 Jun;184:503-8.

Howes O, Smith S.
Alendronic acid for antipsychotic-related osteopenia.
Am J Psychiatry. 2004 Apr;161(4):756. No abstract available.

Howes OD, McDonald C, Cannon M, Arseneault L, Boydell J, Murray RM. Pathways to schizophrenia: the impact of environmental factors.
Int J Neuropsychopharmacol. 2004 Mar;7 Suppl 1:S7-S13.

Howes OD, Bhatnagar A, Gaughran FP, Amiel SA, Murray RM, Pilowsky LS. A prospective study of impairment in glucose control caused by clozapine without changes in insulin resistance. Am J Psychiatry. 2004 Feb;161(2):361-3.

Howes O. one mineral density and prolactin associations in patients with chronic schizophrenia.
Schizophr Res. 2004 Jan 1;66(1):77-8.

Howes O, Ohlsen R, Pilowsky LS. Effect of clozapine on mortality.
Br J Psychiatry. 2003 Nov;183:460.

Howes O, Smith S. yperprolactinaemia caused by antipsychotic drugs. Endocrine antipsychotic side effects must be systemically assessed.
BMJ. 2002 May 25;324(7348):1278.

Howes OD, Salkovskis PM.
Health anxiety in medical students: a comparative study.
Lancet. 1998 May 2;351(9112):1332.

Asselin MC, Howes OD, Nahmias C, Osman S, Grasby PG. Sensitivity of graphically derived constants of FDOPA to plasma concentration of the brain crossing metabolite 3-OMFD (in press)

last updated: Wednesday, May 26, 2010