Dr Cynthia H.Y. Fu  MD PhD FRCPC
Senior Lecturer
Hon Consultant Psychiatrist

activities and interests

depression, schizophrenia

functional and structural MRI, genetics, pattern recognition methods in psychiatry

neurobiological markers and predictors of treatment response, diagnostic classification, self-monitoring

teaching activities

publications

Costafreda SG, Khanna A, Mourao-Miranda J, Fu CHY. Neural correlates of sad faces predict clinical remission to CBT in depression. NeuroReport, 31 March 2009 [epub ahead of print].

Marquand A, Mourao-Miranda J, Brammer MJ, Cleare AJ, Fu CHY. Neuroanatomy of verbal working memory as a diagnostic biomarker for depression. Neuroreport 2008;19:1507-1511.

Fu CHY, Mourao-Miranda J, Costafreda SG, Khanna A, Marquand A, Williams SCR, Brammer MJ. Pattern classification of sad facial processing: toward the development of neurobiological markers in depression. Biological Psychiatry 2008;63:656-662.

Fu CHY, Williams SCR, Cleare AJ, Scott J, Mitterschiffthaler MT, Walsh ND, Donaldson C, Suckling J, Andrew C, Steiner H, Murray RM. Neural responses to sad facial expressions in major depression following cognitive behavior therapy. Biological Psychiatry 2008;64:505-512.

Costafreda SG, Brammer MJ, David AS, Fu CHY. Predictors of amygdala activation during the processing of emotional stimuli: A meta-analysis of 385 PET and fMRI studies. Brain Research Reviews 2008;58:57-70.

Mitterschiffthaler MT, Williams SCR, Walsh ND, Cleare AJ, Donaldson C, Scott J, Murray RM, Fu CHY. Neural basis of the emotional Stroop interference effect in major depression. Psychological Medicine 2008;38:247-256.

Costafreda SG, Brébion G, Allen P, McGuire PK, Fu CH. Affective modulation of external misattribution bias in source monitoring in schizophrenia. Psychological Medicine 2008;38:821-824.

Fu CHY, Brammer MJ, Yaguez L, Allen P, Matsumoto K, van Haren N, Johns L, Weinstein S, Borgwardt S, Broome M, McGuire PK. Increased superior temporal activation associated with external misattributions of self-generated speech in schizophrenia. Schizophrenia Research 2008;100:361-363.

Prata DP, Michelli A, Fu CHY, Picchioni M, Kane F, Kaidindi S, Kravariti E, McDonald C, Toulopoulou T, Miorelli A, Murray R, Collier D, McGuire PK. Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function. Molecular Psychiatry 2008; 13:915-917.

Prata DP, Michelli A, Fu CHY, Picchioni M, Kane F, Kaidindi S, Kravariti E, McDonald C, Demjaha A, Toulopoulou T, DiForti M, Murray R, Collier D, McGuire PK. Opposite effects of COMT Val158Met on cortical function of healthy subjects and patients with schizophrenia. Biological Psychiatry, 2009; 65:473-480.

Michelli A, Prata D, Fu CHY, Picchioni M, Kane F, Kaidindi S, McDonald C, Demjaha A, Kravariti E, Toulopoulou T, Murray R, Collier D, McGuire PK. The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder. Neuroimage 2008; 42:817-826.

Chen CH, Suckling J, Ooi C, Fu CHY, Williams SCR, Walsh N, Mitterschiffthaler MT, Merlo-Pich E, Bullmore ET. Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology 2008;33:1909-1918.

Kumari V, Fannon D, Ffytche DH, Raveendran V, Antonova E, Premkumar P, Cooke MA, Anilkumar AP, Williams SC, Andrew C, Johns LC, Fu CH, McGuire PK, Kuipers E. Functional MRI of verbal self-monitoring in schizophrenia: performance and illness-specific effects. Schizophrenia Bulletin 2008 Nov 7 (epub ahead of print).

Walsh ND, Williams SCR, Brammer MJ, Bullmore ET, Kim J, Suckling J, Mitterschiffthaler MT, Cleare AJ, Merlo Pich E, Mehta M, Fu CHY. A longitudinal fMRI study of verbal working memory in depression following antidepressant therapy. Biological Psychiatry 2007;62:1236-1243.

Fu CHY, Williams SCR, Brammer MJ, Suckling J, Kim J, Cleare AJ, Walsh ND, Mitterschiffthaler MT, Andrew C, Pich EM, Bullmore ET. Neural responses to happy facial expressions in major depression following antidepressant treatment. American Journal of Psychiatry 2007;164:599-607.

Mitterschiffthaler MT, Fu CHY, Dalton JA, Andrew CM, Williams SCR. A functional MRI study of happy and sad affective states induced by classical music. Human Brain Mapping 2007;28:1150-1162.

Chen CH, Ridler K, Suckling J, Williams SCR, Fu CHY, Merlo-Pich E, Bullmore ET. Brain correlates of symptom improvement and depressive symptom severity following antidepressant treatment. Biological Psychiatry 2007;62:407-414.

Fusar-Poli P, Allen P, Lee F, Surguladze S, Tunstall N, Fu CHY, Brammer MJ, Cleare AJ, McGuire PK. Modulation of neural response to happy and sad faces by acute tryptophan depletion. Psychopharmacology (Berl) 2007;193:31-44.

Mechelli A, Allen PP, Amaro Jr E, Fu CHY, Williams SCR, Brammer MJ, Johns LC, McGuire PK. Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations. Human Brain Mapping 2007;28:1213-1222.

Allen PP, Amaro Jr E, Fu CHY, Williams SCR, Brammer MJ, Johns LC, McGuire PK. Neural correlates of the misattribution of self-generated speech in schizophrenia. British Journal of Psychiatry 2007;190:162-169.

Fu CHY, McIntosh AR, Kim J, Chau W, Bullmore ET, Williams SCR, Honey GD, McGuire PK. Modulation of effective connectivity by cognitive demand in phonological verbal fluency. Neuroimage 2006;30:266-271.

Costafreda SG, Fu CHY, Lee L, Everitt B, Brammer MJ, David AS. A systematic review and quantitative appraisal of fMRI studies of verbal fluency: role of left inferior frontal gyrus. Human Brain Mapping 2006;27:799-810.

Allen PP, Cleare AJ, Lee F, Fusar-Poli P, Tunstall N, Fu CHY, Brammer MJ, McGuire PK. Effect of acute tryptophan depletion on pre-frontal engagement. Psychopharmacology 2006;187:486-497.

Fu CHY, Suckling J, Williams SCR, Andrew C, Vythelingum GN, McGuire PK. Effects of psychotic state and task demand on prefrontal function in schizophrenia: an fMRI study of overt verbal fluency. American Journal of Psychiatry 2005;162:485-494.

Rubia K, Lee F, Cleare A, Tunstall N, Fu CHY, Brammer MJ, McGuire PK. Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI. Psychopharmacology (Berl) 2005;179:791-803.

Allen PP, Amaro Jr E, Fu CHY, Williams SCR, Brammer MJ, Johns LC, McGuire PK. Neural correlates of the misattribution of self-generated speech. Human Brain Mapping 2005;26:44-53.

Fu T, Koutstaal W, Fu CHY, Poon L, Cleare AJ. Depression, confidence, and decision: evidence against depressive realism. Journal of Psychopathology and Behavioural Assessment 2005;27:243-252.

Fu CHY, Abel KM, Allin MPG, Gasston D, Costafreda SG, Suckling J, Williams SCR, McGuire PK. Effects of ketamine on prefrontal and striatal regions in an overt verbal fluency task: an fMRI study. Psychopharmacology 2005;183:92-102.

Fu CHY, Vythelingum GN, Brammer MJ, Williams SCR Amaro Jr E, Andrew C, Yaguez L, van Haren NEM, Matsumoto K, McGuire PK. An fMRI study of verbal self-monitoring: neural correlates of auditory verbal feedback. Cerebral Cortex 2005;16:969-977.

Fu CHY, Williams SCR, Cleare AJ, Brammer MJ, Walsh ND, Kim J, Andrew C, Pich EM, Williams PM, Reed LJ, Mitterschiffthaler MT, Suckling J, Bullmore ET. Antidepressant treatment attenuates the neural response to sad faces in major depression: a prospective, event-related functional MRI study. Archives of General Psychiatry 2004;61:877-889.

Allen PP, Johns L, Fu CHY, Broome M, Vythelingum GN, McGuire PK. Misattribution of external speech in patients with hallucinations and delusions. Schizophrenia Research 2004;69:277-287.

Fu CHY, Morgan K, Suckling J, Williams SCR, Andrew C, Vythelingum GN, McGuire PK. An fMRI study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand. Neuroimage 2002;17:871-879.

Honey GD, Fu CHY, Kim J, Brammer MJ, Croudace TJ, Suckling J, Pich EM, Williams SCR, Bullmore ET. Effects of verbal working memory load on cortico-cortical connectivity modelled by path analysis of functional MRI data. Neuroimage 2002;17:573-582.

Amaro Jr E, Williams SCR, Shergill SS, Fu CHY, MacSweeney M, Pichionni M, Brammer MJ, McGuire PK. Acoustic noise and functional magnetic resonance imaging: current strategies and future prospects. Journal of Magnetic Resonance Imaging 2002;16:497-510.

Fu CHY, Reed LJ, Meyer JH, Houle S, Eisfeld B, Kennedy S, Brown GM. Noradrenergic dysfunction in the prefrontal cortex in depression: an [15O] - H2O PET study of the neuromodulatory effects of clonidine. Biological Psychiatry 2001;49:317-325.

Fu CHY, McGuire PK. Functional neuroimaging in psychiatry. Philosophical Transactions of the Royal Society of London B 1999;354:1359-1370.

Fu CHY, Hodges B, Regehr G, Goldbloom DS, Garfinkel P. Is a journal club effective for teaching critical appraisal skills? A controlled trial with residents in psychiatry. Academic Psychiatry 1999;23:205-209.

Fu CHY, Katzman M, Goldbloom D. Valproate/Nortriptyline Interaction. Journal of Clinical Psychopharmacology 1994;14:205-206.

Bunting JW, Fu CHY, Tam JW. Rate constants for the addition of the enolate ion of acetone to quinolinium and acridinium cations. Canadian Journal of Chemistry 1990;68:1762-1768.

Chapters and Book:

Fu CHY, McGuire PK (2003) Hearing voices or hearing the self in disguise? Revealing the neural correlates of auditory hallucinations in schizophrenia. The Self in Neuroscience and Psychiatry (Editors: Kircher T, David AS) Cambridge University Press, UK pp 425-435.

Fu CHY, Walsh ND, Drevets WC (2003) Neuroimaging studies of mood disorders. A Guide to Neuroimaging in Psychiatry (Editors: Fu CHY, Russell T, Senior C, Weinberger DR, Murray RM) Martin Dunitz, UK pp 131-169.

Fu CHY, Russell T, Senior C, Weinberger DR, Murray RM :Editors (2003) A Guide to Neuroimaging in Psychiatry Martin Dunitz, London, UK.

last updated: Friday, April 10, 2009