Professor David A Collier PhD
|contact this person|
|tel||020 7848 0631|
|fax||020 7848 0866|
Institute of Psychiatry
MRC, SGDP Centre
|departments||Social, Genetic and Developmental Psychiatry Centre (MRC)|
David Collier is a Professor of Neuropsychiatric Genetics in the SGDP centre at the Institute of Psychiatry, King’s College, London. He obtained a BSc degree in Biochemistry and Chemistry in 1982 from the University of Sheffield, and completed a PhD in Biophysics in 1986 at King’s College London and the Institute of Cancer Research. He subsequently trained at the University of Alabama at Birmingham, USA from 1986 to 1989, where he worked as a postdoctoral fellow with Professor RD Wells on the biochemistry of repeat sequences in DNA. He was awarded a European Molecular Biology Organisation long term fellowship in 1989 and spent 18 months at the Museum National d’Histoire Naturelle in Paris France, continuing his studies on the biochemistry and biophysics of DNA with Professor Claude Helene. In 1990 he was appointed as a lecturer in Molecular Cytogenetics at the Institute of Psychiatry, where he has been ever since. Professor Collier has a broad range of research interests, including molecular genetics and cytogenetics, the molecular biology of genes and pathways associated with neuropsychiatric disorders, and analysis of psychosocial risk factors and gene-environment interaction. Research focuses on the molecular genetic analysis of the major psychoses, schizophrenia and bipolar disorder, migraine, and the eating disorders anorexia and bulimia nervosa. Current projects include the SGENE project, a European Commission funded genome wide association study (GWAS) of schizophrenia, PsychCNVs, a GWAS of autism and early onset schizophrenia also funded by the European Comission, GCAN, a Wellcome Trust case-control consortium (WTCCC3) GWAS of anorexia nervosa, and work funded by the Guy’s and St Thomas Trust aimed at using genes and environment to predict risk of psychosis. Professor Collier has published over 200 articles in peer-reviewed journals. He works closely with the Eating Disorders Unit and the SGDP Statistical Genetics Group.
activities and interests
The Collier research group consists of a vibrant mixture of BSc and MSc projects students, PhD students, and postdoctoral researchers, listed below.
Tao Li MD PhD Senior Lecturer
Evangelos Vassos MD PhD GSTT Postdoctoral Fellow (with Cathryn Lewis)
Isabel Krug (EMBO Postdoctoral Fellow)
Denes Kovacs (Marie Curie Postdotoral fellow)
Thomas Liao PhD Visiting Researcher
Katherinne Navarette PhD student
Sietske Helder BSc PhD student
Fatemah Al-Mosawi PhD student
Maria Tropeano Visiting Scientist
Kinga Royzniak MSc project student
Susanne Sijogo MSc project student
Sara Campos De Sousa PhD student
Hannah Grayton MPhil student
Danai Dima PhD Postdoctoral Researcher (with Sophia Frangou)
Frankie Bishopp PA
Sagnik Bhattacharyya PhD student (with Philip McGuire)
Sarah Jugurnauth PhD student (with Gerome Breen)
|Lecturer||Neuroscience » Masters (MSc)|
|Social, Genetic & Developmental Psychiatry » Masters (MSc)|
|Psychiatric Research » Masters (MSc)|
|Research on Stigma and Discrimination » Summer School|
L. Athanasiu, M. Mattingsdal, A. K. Kahler, et al. Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J.Psychiatr.Res., 2010.
C. Gelegen, E. Pjetri, I. C. Campbell, D. A. Collier, H. Oppelaar, and M. J. Kas. Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule. Eur.Neuropsychopharmacol. 20 (5):317-326, 2010.
A. Ingason, I. Giegling, S. Cichon, et al. A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Hum.Mol.Genet. 19 (7):1379-1386, 2010.
S. Steinberg, O. Mors, A. D. Borglum, et al. Expanding the range of ZNF804A variants conferring risk of psychosis. Mol.Psychiatry, 2010.
E. Vassos, E. Bramon, M. Picchioni, M. Walshe, F. M. Filbey, E. Kravariti, C. McDonald, R. M. Murray, D. A. Collier, and T. Toulopoulou. Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls. J.Psychiatr.Res., 2010.
Q. Wang, E. Vassos, W. Deng, X. Ma, X. Hu, R. M. Murray, D. A. Collier, and T. Li. Factor structures of the neurocognitive assessments and familial analysis in first-episode schizophrenia patients, their relatives and controls. Aust.N.Z.J.Psychiatry 44 (2):109-119, 2010.
.Med. 39 (1):105-114, 2009.
de Mooij-van Malsen AJ, H. A. van Lith, H. Oppelaar, J. Hendriks, Wit M. de, E. Kostrzewa, G. Breen, D. A. Collier, B. Olivier, and M. J. Kas. Interspecies trait genetics reveals association of Adcy8 with mouse avoidance behavior and a human mood disorder. Biol.Psychiatry 66 (12):1123-1130, 2009.
D. R. Hardoon, U. Ettinger, J. Mourao-Miranda, E. Antonova, D. Collier, V. Kumari, S. C. Williams, and M. Brammer. Correlation-based multivariate analysis of genetic influence on brain volume. Neurosci.Lett. 450 (3):281-286, 2009.
A. Ingason, D. Rujescu, S. Cichon, et al. Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol.Psychiatry, 2009.
M. J. Kas, C. Gelegen, L. C. Schalkwyk, and D. A. Collier. Interspecies comparisons of functional genetic variations and their implications in neuropsychiatry. Am.J.Med.Genet.B Neuropsychiatr.Genet. 150B (3):309-317, 2009.
D. Kovacs, E. Vassos, X. Liu, X. Sun, J. Hu, G. Breen, P. Tompa, D. A. Collier, and T. Li. The androgen receptor gene polyglycine repeat polymorphism is associated with memory performance in healthy Chinese individuals. Psychoneuroendocrinology 34 (6):947-952, 2009.
D. P. Prata, A. Mechelli, C. H. Fu, M. Picchioni, T. Toulopoulou, E. Bramon, M. Walshe, R. M. Murray, D. A. Collier, and P. McGuire. Epistasis between the DAT 3’ UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proc.Natl.Acad.Sci.U.S.A 106 (32):13600-13605, 2009.
D. P. Prata, A. Mechelli, C. H. Fu, M. Picchioni, F. Kane, S. Kalidindi, C. McDonald, O. Howes, E. Kravariti, A. Demjaha, T. Toulopoulou, M. Diforti, R. M. Murray, D. A. Collier, and P. K. McGuire. Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia. Biol.Psychiatry 65 (6):473-480, 2009.
D. P. Prata, A. Mechelli, M. M. Picchioni, C. H. Fu, T. Toulopoulou, E. Bramon, M. Walshe, R. M. Murray, D. A. Collier, and P. McGuire. Altered effect of dopamine transporter 3’UTR VNTR genotype on prefrontal and striatal function in schizophrenia. Arch.Gen.Psychiatry 66 (11):1162-1172, 2009.
D. Rujescu, A. Ingason, S. Cichon, et al. Disruption of the neurexin 1 gene is associated with schizophrenia. Hum.Mol.Genet. 18 (5):988-996, 2009.
H. Stefansson, R. A. Ophoff, S. Steinberg, et al. Common variants conferring risk of schizophrenia. Nature 460 (7256):744-747, 2009.
U. Ettinger, V. Kumari, D. A. Collier, J. Powell, S. Luzi, T. M. Michel, O. Zedomi, and S. C. Williams. Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic. Neuropsychopharmacology 33 (13):3046-3057, 2008.
M. A. Ferreira, M. C. O’Donovan, Y. A. Meng, Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat.Genet. 40 (9):1056-1058, 2008.
C. Gelegen, Heuvel J. van den, D. A. Collier, I. C. Campbell, H. Oppelaar, E. Hessel, and M. J. Kas. Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule. Genes Brain Behav. 7 (5):552-559, 2008.
T. Li, X. Ma, X. Hu, Y. Wang, C. Yan, H. Meng, X. Liu, T. Toulopoulou, R. M. Murray, and D. A. Collier. PRODH gene is associated with executive function in schizophrenic families. Am.J.Med.Genet.B Neuropsychiatr.Genet. 147B (5):654-657, 2008.
D. P. Prata, A. Mechelli, C. H. Fu, M. Picchioni, F. Kane, S. Kalidindi, C. McDonald, E. Kravariti, T. Toulopoulou, A. Miorelli, R. Murray, D. A. Collier, and P. K. McGuire. Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function. Mol.Psychiatry 13 (10):915-7, 909, 2008.
D. P. Prata, A. Mechelli, C. H. Fu, M. Picchioni, F. Kane, S. Kalidindi, C. McDonald, E. Kravariti, T. Toulopoulou, A. Miorelli, R. Murray, D. A. Collier, and P. K. McGuire. The DISC1 Ser704Cys polymorphism is associated with prefrontal function in healthy individuals. Mol.Psychiatry 13 (10):909, 2008.
H. Stefansson, D. Rujescu, S. Cichon, et al. Large recurrent microdeletions associated with schizophrenia. Nature 455 (7210):232-236, 2008.
E. Vassos, P. C. Sham, G. Cai, H. Deng, X. Liu, X. Sun, J. Zhao, R. M. Murray, D. A. Collier, and T. Li. Correlation and familial aggregation of dimensions of psychosis in affected sibling pairs from China. Br.J.Psychiatry 193 (4):305-310, 2008.
S. C. de Sousa, A. Karwautz, C. Wober, G. Wagner, G. Breen, H. E. Zesch, A. Konrad, A. Zormann, C. Wanner, C. Kienbacher, D. A. Collier, and C. Wober-Bingol. A dopamine D4 receptor exon 3 VNTR allele protecting against migraine without aura. Ann.Neurol. 61 (6):574-578, 2007.
C. Gelegen, D. A. Collier, I. C. Campbell, H. Oppelaar, Heuvel J. van den, R. A. Adan, and M. J. Kas. Difference in susceptibility to activity-based anorexia in two inbred strains of mice. Eur.Neuropsychopharmacol. 17 (3):199-205, 2007.
M. J. Kas, C. Fernandes, L. C. Schalkwyk, and D. A. Collier. Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men. Mol.Psychiatry 12 (4):324-330, 2007.
last updated: Friday, April 16, 2010