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Professor Gunter Schumann  MD PhD
Chair of Biological Psychiatry

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tel020-7848-5314
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address

Institute of Psychiatry
Box  P080
De Crespigny Park
London
United Kingdom, SE5 8AF

location C1.34
MRC, SGDP Centre
departmentsMRC Social, Genetic and Developmental Psychiatry Centre

biography

I am Professor of Biological Psychiatry and Head of the Section at the Social, Genetic and Developmental Psychiatry Centre (MRC), and Honorary Consultant at South London and Maudsley NHS Foundation Trust (SLaM), working at the National Psychosis Unit.

Before joining the IoP in 2005, I trained (postgraduate) and worked at Harvard University, at the University of Freiburg and at the Central Institute of Mental Health, University of Heidelberg, Germany.

My general research interests are in etiological and diagnostic stratification of psychiatric patients to identify neurobehavioural phenotypes, which allow the development of predictive and prognostic biomarkers. Our group thus works on the identification of neurobehavioural mechanisms of psychiatric disorders, including addictions. We pursue an interdisciplinary approach, using neuroimaging, functional genetic and epigenetic methods as well as molecular biological and bioinformatic techniques.

I am coordinating an FP6 European research project IMAGEN - Reinforcement-related behaviour in normal brain function and psychopathology. IMAGEN is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ 14 year old adolescents, which investigates the neurobiological and genetic basis of individual differences in brain responses to reward, punishment and emotional cues in adolescents. I am also leading the WP Biomedical Research of the FP7 Project ROAMER - a European roadmap for mental health research.

In addition to the European Commission, our group receives funding from the MRC and FAS (Sweden).

publications

SELECTED PUBLICATIONS:

• Nymberg C, Jia T, Lubbe S, Ruggeri B, Desrivieres S, Barker GJ, Büchel C, Fauth-Buehler M, Cattrell A, Conrod PJ, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Mann K, Paillère-Martinot ML, Nees F, Paus T, Rietschel M, Robbins TW, Smolka MN, Banaschewski T, Rubia K, Loth E, Schumann G. and the IMAGEN consortium. Neural mechanisms of ADHD symptoms are stratified by MAOA-genotype. Biological Psychiatry (in press)

• Paillère Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL; IMAGEN consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Mol Psychiatry. 2013 Apr 30.

• Amarasinghe M, Tan H, Larkin S, Ruggeri B, Lobo S, Brittain P, Broadbent M, Baggaley M, Schumann G. Banking the brain. Addressing the ethical challenges of a mental-health biobank. EMBO Rep. 2013 May 2;14(5):400-4.

• Brittain PJ, Lobo SE, Rucker J, Amarasinghe M, Anilkumar AP, Baggaley M, Banerjee P, Bearn J, Broadbent M, Butler M, Campbell CD, Cleare AJ, Dratcu L, Frangou S, Gaughran F, Goldin M, Henke A, Kern N, Krayem A, Mufti F, McIvor R, Needham-Bennett H, Newman S, Olajide D, O’Flynn D, Rao R, Rehman IU, Seneviratne G, Stahl D, Suleman S, Treasure J, Tully J, Veale D, Stewart R, McGuffin P, Lovestone S, Hotopf M, Schumann G. Harnessing clinical psychiatric data with an electronic assessment tool (OPCRIT+): the utility of symptom dimensions. PLoS One. 2013;8(3):e58790.

• Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S, Nymberg C, Banaschewski T, Barker GJ, Büchel C, Carvalho F, Conrod PJ, Desrivières S, Fauth-Bühler M, Fernandez-Medarde A, Flor H, Gallinat J, Garavan H, Bokde AL, Heinz A, Ittermann B, Lathrop M, Lawrence C, Loth E, Lourdusamy A, Mann KF, Martinot JL, Nees F, Palkovits M, Paus T, Pausova Z, Rietschel M, Ruggeri B, Santos E, Smolka MN, Staehlin O, Jarvelin MR, Elliott P, Sommer WH, Mameli M, Müller CP, Spanagel R, Girault JA, Schumann G; IMAGEN Consortium. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21128-33.

• Easton A, Lourdusamy A, Loth E, Giese KP, de Quervain D, Papassotiropoulos A, Fernandes C, Müller C, Schumann G and the IMAGEN consortium. CAMK2A polymorphisms predict working memory performance in humans. Mol Psychiatry, 2012 Sep 25.

• Schilling C, Kühn S, Paus T, Romanowski A, Banaschewski T, Barbot A, Barker G, Bruehl R, Büchel C, Conrod P, Dalley J, Flor H, Ittermann B, Ivanov N, Mann K, Martinot JL, Nees F, Rietschel M, Robbins T, Smolka M, Ströhle A, Kathmann N, Garavan H, Heinz A, Schumann G, Juergen Gallinat and the IMAGEN consortium. Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning. Mol. Psychiatry, 2013 May;18(5):624-30

• Whelan R, Conrod P, Poline JB, Banaschewski T, Barker GJ, Bellgrove MA, Büchel C, Byrne M, Cummins T, Fauth-Bühler M, Flor H, Gallinat J, Heinz A, Ittermann B, Lourdusamy A, Mann K, Martinot JL, Lalor EC, Lathrop M, Loth E, Paus T, Rietschel M, Smolka MN, Spanagel R, Stephens D, Struve M, Thyreau B, Vollstaedt-Klein S, Robbins TW, Schumann G, Garavan H, the IMAGEN consortium. Individual differences in the neurobiology of inhibitory control in adolescence. Nature Neuroscience, 2012 Apr 29

• Jason L. Stein, Sarah E. Medland, Alejandro Arias Vasquez, Derrek P. Hibar, Rudy E. Senstad, Anderson M. Winkler, Roberto Toro, Katja Appel, Richard Bartecek, Ørjan Bergmann, Manon Bernard, Andrew A. Brown, Dara Canon, Mallar Chakravarty, Andrea Christoforou, Martin Domin, Oliver Grimm, Marisa Hollinshead, Avram J. Holmes, Georg Homuth, Jouke-Jan Hottenga, Lorna M. Lopez, Narelle K. Hansell, Kristy S. Hwang, Sungeun Kim Gonzalo Laje, Phil H. Lee, Xinmin Liu, Eva Loth, Anbarasu Lourdusamy, Susana Muñoz Maniega, Morten Mattingsdal, Kwangsik Nho, Allison C. Nugent, Carol O’Brien, Martina Papmeyer, Benno Pütz, Mark Rijpkema, Shannon L. Risacher, Emma J. Rose, Li Shen, Emma Sprooten, Eric Strengman, Alexander Teumer, Kristel van Eijk, Theo G.M. van Erp, Marie-Jose van Tol, Katharina Wittfeld, Christiane Wolf, Saskia Woudstra, Andre Aleman, Saud Alhusaini, Laura Almasy, Elisabeth B. Binder, David Brohawn, Rita M. Cantor, Melanie A. Carless, Aiden Corvin, Michael Czisch, Joanne E. Curran, Gail Davies, Norman Delanty, Chantal Depondt, Ravi Duggirala, Thomas D. Dyer, Susanne Erk, Jesen Fagerness, Peter T. Fox, Nelson B. Freimer, Michael Gill, Harald H.H. Göring, David Höhn, Norbert Hosten, Matthew P. Johnson, Dalia Kasperaviciute, Jack W. Kent, Jr., Peter Kochunov, Jack L. Lancaster, Stephen M. Lawrie, David C. Liewald, René Mandl, Mar Matarin, Manuel Mattheisen, Eva Meisenzahl, Ingrid Melle, Eric K. Moses, Thomas W. Mühleisen, Matthias Nauck, Marcus M. Nöthen, Rene L. Olvera, G. Bruce Pike, Ralf Puls, Ivar Reinvang, Miguel E. Rentería, Marcella Rietschel, Joshua Roffman, Natalie A. Royle, Dan Rujescu, Jonathan Savitz, Hugo G. Schnack, Knut Schnell, Vidar M. Steen, Maria C. Valdés Hernández, Martijn Van den Heuvel, Nic J. van der Wee, Neeltje E.M. Van Haren, Joris A. Veltman, Henry Völzke, Henrik Walter, Ingrid Agartz, Dorret I. Boomsma, Gianpiero L. Cavalleri, Anders M. Dale, Srdjan Djurovic, Wayne C. Drevets, Peter Hagoort, Jeremy Hall, Clifford R. Jack, Jr., Tatiana M. Foroud, Stephanie Le Hellard, Fabio Macciardi, Grant W. Montgomery, Jean Baptiste Poline, David J. Porteous, Sanjay M. Sisodiya, John M. Starr, Jessika Sussmann, Arthur W. Toga, Dick J. Veltman, Michael W. Weiner, the Alzheimer’s Disease Neuroimaging Initiative, IMAGEN Consortium, Saguenay Youth Study Group, Joshua C. Bis, M. Arfan Ikram, Albert V. Smith, Christophe Tzourio, Meike W. Vernooij, Lenore J. Launer, Charles DeCarli, Sudha Seshadri, Ole A. Andreassen, Liana G. Apostolova, Mark E. Bastin, John Blangero, Han G. Brunner, Randy L. Buckner, Sven Cichon, Giovanni Coppola, Greig I. de Zubicaray, Ian J. Deary, Gary Donohoe, Eco J.C. de Geus, Thomas Espeseth, Guillén Fernández, David C. Glahn, Hans J. Grabe, Mark Jenkinson, René S. Kahn, Colm McDonald, Andrew M. McIntosh, Francis J. McMahon, Katie L. McMahon, Andreas Meyer-Lindenberg, Derek W. Morris, Bertram Müller-Myhsok, Thomas E. Nichols, Roel A. Ophoff, Tomas Paus, Zdenka Pausova, Brenda W. Penninx, Hilleke E. Hulshoff Pol, Steven G. Potkin, Philipp G. Sämann, Andrew J. Saykin, Gunter Schumann, Jordan W. Smoller, Joanna M. Wardlaw, Margaret J. Wright, Barbara Franke, Nicholas G. Martin, Paul M. Thompson, for the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium Common genetic polymorphisms contribute to the variation in human hippocampal and intracranial volume. Nature Genetics, 44(5):552-561

• Eva Loth, Fabiana Carvalho, Gunter Schumann. The contribution of imaging genetics to the development of predictive markers for addictions. Trends in Cognitive Sciences; 2011; 15(9):436-46

• Dong L, Bilbao A, Laucht M, Leonardi-Essmann F, Henriksson R, Yakovleva T, Johann M, Desrivieres S, Lourdusam A, Clarke TK, Cichon S, Blomeyer D, Treutlein J, Wodarz N, Zill P, Soyka M, Albrecht U, Rietschel M, Mann K, Lathrop M, Spanagel R, Bakalkin G, Schumann G. Genotype-specific expression of human Period1 influences stress-induced alcohol consumption American Journal Psychiatry; 2011 Oct;168(10):1090-8

• Müller CP, Schumann G. Drugs as instruments – a new framework for non-addictive psychoactive drug use. Behavioural Brain Sciences; 2011;34: 293-347

• Desrivières S, Pronko SP, Lourdusamy A, Ducci F, Hoffman PL, Wodarz N, Ridinger M, Rietschel M, Zelenika D, Lathrop M, Schumann G, Tabakoff B. Sex-specific role for adenylyl cyclase 7 in alcohol dependence. Biol Psychiatry. 2011 Apr 7. [Epub ahead of print] PMID: 21481845

• Schumann G, Coin L, Lourdusamy A, Charoen P, Berger KH, Bilbao A, Stacey D. Aliev FA, Khan AA, Amin N, Aulchenko YS, Bakker SJL, Balkau B, Beulens JWJ, de Boer RA, Beury D, Bots ML, Breetvelt EJ, Cauchi S, Cavalcanti-Proença C, Chambers JC, Clarke TK, Dahmen N, de Geus EJC, Desrivieres S, Dick D, Ducci F, Edenberg HJ, Esko T, Fernández-Medarde A, Foroud T, Freimer NB, Girault JA, Grobbee DE, Guarrera S, Hartikainen AL, Heath AC, Hesselbrock V, Hofman A, Hottenga JJ, Isohanni M, Kaprio J, Khaw KT, Kuehnel B, Laitinen J, Surakka I, Lobbens S, Luan J, Mangino M, Maroteaux M, Matullo G, McCarthy MI, Navis G, Numans ME, Núñez A, Nyholt D, Onland-Moret CN, Oostra BA, Penninx BW, Polidoro S, Pouta A, Prokopenko I, Ricceri F, Santos E, Smit JH, Soranzo N, Song K, Sovio U, Stumvoll M, Thorgeirsson TE, Tönjes A, Uiterwaal CSPM, Uitterlinden AG, van der Harst P, van der Schouw YT, Vogelzangs N, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Whitfield J, Wichmann HE, Willemsen G, Witteman JCM, Yuan X, Zhai G, Zhao JH, Zhang W, Martin NG, Metspalu A, Doering A, Scott J, Spector TD, Loos RJF, Boomsma D, Froguel P, Mooser V, Peltonen L, van Duijn CM, Vineis P, Kooner J, Spanagel R, Heberlein U, Jarvelin MR, Elliott P. Genome-wide association and genetic functional studies identify AUTS2 in the regulation of alcohol consumption. Proc National Academy of Sciences USA. 2011 Apr 6; [Epub ahead of print] PMID: 21471458

• Peters J, Bromberg U, Schneider S, Brassen S, Menz M, Banaschewski T, Barker G, Conrod PJ, Flor H, Garavan H, Heinz A, Itterman B, Lathrop M, Martinot JL, Paus T, Poline JB, Robbins TW, Rietschel M, Smolka M, Ströhle A, Loth E, Schumann G, Büchel C, the IMAGEN consortium. Reduced neural reward sensitivity in adolescent smokers. American Journal Psychiatry 2011 March 1; PMID: 21362742.

• Clarke TK, Laucht M, Ridinger M, Wodarz N, Rietschel M, Maier W, Lathrop M, Lourdsamy A, Zimmermann US, Desrivieres S, Schumann G. GIRK2 mediates gene x environment interactions in adolescent alcohol drinking and is associated with alcohol dependence. Neuropsychopharmacology 2011 Feb 9. [Epub ahead of print] PMID: 21307845

• Rucker J, Newman S, Gray J, Gunasinghe C, Broadbent M, Baggaley M, Denis M, Turp J, Stewart R, Lovestone S, Schumann G, Farmer A, McGuffin P. OPCRIT+: an Electronic System for Psychiatric Diagnosis and Data Collection in Clinical and Research Settings. British Journal Psychiatry; in press

• Ducci F, Kaakinen M, Pouta A, Hartikainen AL, Veijola J, Isohanni M, Charoen P, Coin L, Hoggart C, Ekelund J, Peltonen L, Freimer N, Elliott P, Schumann G, Järvelin MR. TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 Influence Different Pathways Leading to Smoking Behavior from Adolescence to Mid-Adulthood. Biol Psychiatry. 2011 Apr 1; 69(7):650-60. Epub 2010 Dec 17. PMID: 21168125

• Schumann G, Loth E, Banaschewski T, Barbot A, Barker G, Büchel C, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Mallik C, Mann K, Martinot JL, Paus T, Poline JB, Robbins TW, Rietschel M, Reed L, Smolka M, Spanagel R, Speiser C, Stephens DN, Ströhle A, Struve M, IMAGEN consortium. The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. Mol Psychiatry 2010 15(12):1128-39; PMID: 21102431

• Dixon CI, Morris HV, Breen G, Desrivieres S, Vallada H, Rosahl TW, Guindalini C, Laranjeira R, Messas G, King SL, Atack JR, Schumann G, Stephens DN Cocaine incentive-learning and addiction are linked to a2-containing GABAA receptors. Proc Natl Acad Sci U S A 2010; 107(5):2289-94; PMID: 20133874

• Bilbao A, Rodriguez Parkitna J, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Bading H, Rodriguez de Fonseca F, Guindalini C, Vallada H, Laranjeira R, Schumann G, Schütz G, Spanagel R. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc Natl Acad Sci U S A 2008; 105(45):17549-54; PMID: 19001277

• Wrase J, Makris N, Braus DF, Mann K, Smolka M, Kennedy DN, Caviness VS, Hodge SM, Tang L, Albaugh DM, Ziegler DA, Davis OC, Kissling C, Schumann G, Breiter H, Heinz A. Amygdala volume associated with alcohol abuse relapse and craving. American Journal of Psychiatry 2008; 165(9):1179-84; PMID: 18593776

• Wong CCY, Schumann G. Genetics of Addictions: Strategies to address heterogeneity and polygenicity of substance use disorders. Proc Royal Society 2008; 363(1507):3213-22; PMID: 18640915

• Schumann G, Frank J, Preuss U, Dahmen N, Laucht M, Rujescu D, Matsuda F, Hinckers A, Depner M, Wellek S, Treutlein J, Szegedi A, Giegling I, Blomeyer D, Heinz A, Lathrop M, Spanagel R, Soyka M, Mann K. Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and risk drinking behaviour. Archives of General Psychiatry, 2008; 65(7):826-838; PMID: 18606955

• Blomeyer D, Treutlein J, Esser G, Schmidt MH, Schumann G, Laucht M. Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. Biological Psychiatry 2008; 63(2):146-51; PMID: 17597588

• Heinz A, Smolka MN, Braus DF, Wrase J, Beck A, Flor H, Mann K, Schumann G, Buchel C, Hariri AR, Weinberger DR. Serotonin Transporter Genotype (5-HTTLPR): Effects of Neutral and Undefined Conditions on Amygdala Activation. Biol Psychiatry 2007; 15;61(8):1011-4; PMID: 17157270

• Smolka MN, Bühler M, Schumann G, Klein S, Hu XC, Moayer M, Zimmer A, Wrase J, Kissling C, Flor H, Mann K, Braus DF, Büchel C, Goldman D, Heinz A. Gene-gene effects on central processing of aversive stimuli. Molecular Psychiatry 2007;12(3):307-17; PMID: 17211439

• Schumann G. Identifying neurobiological mechanisms of addictive behaviour (Okey Lecture 2006). Addiction 2007; 102(11):1689-95; PMID: 17935575

• Hinckers A, Laucht M, Schmidt MH, Mann K, Schumann G, Schuckit M, Heinz A. Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents. Biological Psychiatry 2006; 60: 282-7; PMID: 16497275

• Treutlein J, Kissling C, Frank J, Wiemann S, Depner M, Saam C, Lascorz J, Soyka M, Preuss U, Rujescu D, Skowronek MH, Rietschel M, Dong L, Spanagel R, Heinz A, Laucht M, Mann K, Schumann G. Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Molecular Psychiatry 2006; 11: 594-602; PMID: 16550213

• Heinz A, Reimold M, Hermann D, Wrase J, Mundle G, Dohmen B M, Braus DF, Schumann G, Machulla H J, Bares R, Mann K. Brain reward system alterations in alcoholism – an in vivo [11C] Carfentanil PET study. Archives General Psychiatry 2005; 62: 57-64; PMID: 15630073

• Heinz A, Braus DF, Smolka MN, Wrase J, Hermann D, Klein S, Grüsser SM, Flor H, Schumann G, Mann K, Büchel C. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience 2005; 8: 20-21; PMID: 15592465

• Smolka M, Schumann G, Wrase J, Grüsser M, Flor F, Mann K, Braus DF, Goldman D, Büchel C, Heinz A. Catechol O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neuroscience 2005; 25: 836-42; PMID: 15673663

• Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Chiara Magnone M, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U. The clock gene Period2 influences the glutamatergic system and thereby modulates alcohol consumption. Nature Medicine 2005; 11: 35-42; PMID: 15608650
o See also: Yuferov V, Bart G, Kreek MJ. Clock reset for alcoholism. Nature Medicine 2005; 11: 23-24 (News and Views)









last updated: Tuesday, May 14, 2013