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Dr Matthew J Kempton  MSci MSc PhD
MRC Career Development Fellow

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tel020 3228 3053 or 020 7848 0514
fax020 3228 2116

Institute of Psychiatry
Box  P089
De Crespigny Park
United Kingdom, SE5 8AF

location 6th floor
and Centre for Neuroimaging Sciences
Psychosis Studies
alsoSection of Neuroimaging


My main interests are neuroimaging (particularly structural MRI) in psychosis disorders such as schizophrenia and bipolar disorder. I currently coordinate a longitudinal multicentre neuroimaging study of individuals at ultra high risk of developing psychosis.



Fusar-Poli P, Kempton MJ, Rosenheck RA (2013) Efficacy and safety of second-generation long-acting injections in schizophrenia: a meta-analysis of randomized-controlled trials. Int Clin Psychopharmacol. 2013 2013 Mar;28(2):57-66.


Fusar-Poli P, Bonoldi I, Yung AR, Borgwardt S, Kempton MJ, Valmaggia L, Barale F, Caverzasi E, McGuire P. (2012) Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatry. 2012 Mar;69(3):220-9

Nitric oxide plasma/serum levels in patients with schizophrenia: a systematic review and meta-analysis (2012) Maia-de-Oliveira JP, Trzesniak C, Oliveira IR, Kempton MJ, de Rezende TM, Iego S, Baker GB, Dursun SM, Machado-de-Sousa JP, Hallak JE Rev Bras Psiquiatr. 2012 Oct;34 Suppl 2:S149-55.

Benedict C, Brooks SJ, Kullberg J, Burgos J, Kempton MJ, Nordenskjöld R, Nylander R, Kilander L, Craft S, Larsson EM, Johansson L, Ahlström H, Lind L, Schiöth HB. (2012) Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly. Diabetes Care. 2012 Mar;35(3):488-94.

Brooks SJ, Benedict C, Burgos J, Kempton MJ, Kullberg J, Nordenskjöld R, Kilander L, Nylander R, Larsson EM, Johansson L, Ahlström H, Lind L, Schiöth HB. (2012) Late-life obesity is associated with smaller global and regional gray matter volumes: a voxel-based morphometric study.Int J Obes (Lond). 2012 Jan 31. doi: 10.1038/ijo.2012.13. [Epub ahead of print]


Kempton MJ, Salvador Z, Munafo MR, Geddes JR, Simmons A, Frangou S, Williams SCR. Structural Neuroimaging studies in Major Depressive Disorder: Meta-analysis and comparison with Bipolar Disorder (2011) Archives of General Psychiatry 68(7) 675-90

Kempton MJ, Underwood TSA, Brunton S, Stylios S, Schmechtig A, Ettinger U, Smith MS, Simon Lovestone S, Crum WR, Frangou S, Williams SCR, Simmons A. (2011) A comprehensive testing protocol for MRI neuroanatomical segmentation techniques: Evaluation of a novel lateral ventricle segmentation method. NeuroImage 2011 Jul 30 (Epub ahead of print) doi: 10.1016/j.neuroimage.2011.06.080

Kempton MJ, Ettinger U, Foster R, Williams SC, Calvert GA, Hampshire A, Zelaya FO, O’Gorman RL, McMorris T, Owen AM, Smith MS (2011) Dehydration affects brain structure and function in healthy adolescents. Hum Brain Mapp. 32 (1) 71-9

Trzesniak C, Kempton MJ, Busatto GF, Oliveira IR, Almeida AG, Kambeitz J, Ferrari MC, Filho AS, Chagas MH, Zuardi AW, Hallak JE, McGuire PK, Crippa JA (2011)
Adhesio Interthalamica Alterations in Schizophrenia Spectrum Disorders: A systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry Feb 4. Epub ahead of print

Duka T, Trick L, Nikolaou K, Gray MA, Kempton MJ, Williams H, Williams SC, Critchley HD, Stephens DN (2011) Unique Brain Areas Associated with Abstinence Control Are Damaged in Multiply Detoxified Alcoholics Biol Psychiatry. 2011 May 23. (Epub ahead of print) doi:10.1016/j.biopsych.2011.04.006

Trzesniak C, Irismar OR, Kempton MJ, Almeida A, MHN Chagas. Chagasa MHN, Ferrari MCF, Filho AS, Zuardia AW, Prado DA, Busatto GF, McGuire PK, Hallak JEC, José Alexandre S. Crippa JASC (2011) Are cavum septum pellucidum abnormalities more common in schizophrenia spectrum disorders? A systematic review and meta-analysis Schizophr Res 125 (1) 1-12

Lelli-Chiesa G, Kempton MJ, Jogia J, Collier D, Powell J, Frangou S (2011) The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives Psychol Med. 2011 Apr;41(4):779-88.

Fusar-Poli P, Borgwardt S, Crescini A, Deste G, Kempton MJ, Lawrie S, Mc Guire P, Sacchetti E (2011) Neuroanatomy of vulnerability to psychosis: a voxel-based meta-analysis. Neurosci Biobehav Rev. 2011 Apr;35(5):1175-85


Kempton MJ, Stahl D, Williams SCR, DeLisi LE (2010). Progressive lateral ventricular enlargement in schizophrenia: a meta-analysis of longitudinal MRI studies. Schizophr Res 120(1-3) 54-62

Kempton MJ (2010) Response to letter by Scott Kaplan. Schizophr Res 124 (1-3) 245

Germana C, Kempton MJ, Sarnicola A, Christodoulou T, Haldane M, Hadjulis, Girardi P, Tatarelli R, Frangou S (2010) The effects of Lithium and anticonvulsants on brain structure in bipolar disorder. Acta Psychiatr Scand 122(6): 481-7

Takahashi T, Walterfang M, Wood SJ, Kempton MJ, Jogia J, Lorenzetti V, Soulsby B, Suzuki M, Velakoulis D, Pantelis C, Frangou S (2010) Pituitary volume in patients with bipolar disorder and their first-degree relatives. J Affect Disord 124(3) 256-61


Kempton MJ, Ruberto G, Vassos E, Tatarelli R, Girardi P, Collier D, Frangou S (2009) The CACNA1C risk allele for bipolar disorder impacts on cerebral gray matter volume in healthy subjects. American Journal of Psychiatry 166(12) 1413-4

Kempton MJ, Haldane M, Jogia J, Grasby PM, Collier D, Frangou S (2009) Dissociable brain structural changes associated with predisposition, resilience and disease expression in Bipolar Disorder. Journal of Neuroscience 29(35) 10863-8

Kempton MJ, Haldane M, Jogia J, Christodoulou T, Powell J, Collier D, Williams SCR, Frangou S (2009) The effects of gender and COMT val158met polymorphism on fearful facial affect recognition: An fMRI study. The International Journal of Neuropsychopharmacology 12(3):371-81

Kempton MJ, Ettinger U, Schmechtig A, Winter EM, Smith L, McMorris T, Wilkinson ID, Williams SC, Smith MS (2009) Effects of acute dehydration on brain morphology in healthy humans. Human Brain Mapping. 30(1):291-8

Sarnicola A, Kempton M, Germanà C, Haldane M, Hadjulis M, Christodoulou T, Koukopoulos A, Girardi P, Tatarelli R, Frangou S (2009) No Differential Effect of Age on Brain Matter Volume and Cognition in Bipolar Patients and Healthy Individuals. Bipolar Disorders 11(3):316-22

Walterfang M, Wood AG, Barton S, Velakoulis D, Chen J, Reutens DC, Kempton MJ, Haldane M, Pantelis C, Frangou S (2009) Corpus callosum size and shape alterations in individuals with bipolar disorder and their first-degree relatives. Prog Neuropsychopharmacol Biol Psychiatry 33(6) 1050-7

Bose SK, Mackinnon T, Mehta MA, Turkheimer FE, Howes OD, Selvaraj S, Kempton MJ, Grasby PM (2009) The effect of ageing on grey and white matter reductions in schizophrenia. Schizophrenia Research Jul;112(1-3):7-13

Before 2009

Kempton MJ, Geddes JR, Ettinger U, Williams SCR, Grasby PM (2008) Meta-analysis, database and meta-regression of 98 structural imaging studies in bipolar disorder. Archives of General Psychiatry 65(9) 1017-1032.

Reid AG, Daglish MR, Kempton MJ, Williams TM, Watson B, Nutt DJ, Lingford-Hughes AR (2008) Reduced thalamic grey matter volume in opioid dependence is influenced by degree of alcohol use: a voxel-based morphometry study. J Psychopharmacol Jan;22(1):7-10.

Clark L, Kempton MJ, Scarna A, Grasby PM, Goodwin GM (2005) Sustained attention deficit confirmed in euthymic bipolar disorder, but not in first-degree relatives of bipolar patients or euthymic unipolar depression. Biological Psychiatry 57(2) 183-187.

last updated: Thursday, May 09, 2013