Dr Bill Crum BSc. D.Phil PGCAP
Senior Research Worker
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Institute of Psychiatry
Centre for Neuroimaging Sciences
NIHR BRC for Mental Health
Bill Crum trained as a physicist gaining a BSc in Theoretical Physics in 1988 and a D.Phil in Computational Physics in 1992, both from the University of York. He worked as a post-doc within the Centre of Medical Imaging Research at The University of Leeds and Leeds General Infirmary on projects concerning CT-SPECT registration and analysis of tagged cardiac MRI. From 1997 to 2001 Bill worked at the Dementia Research Centre (Institute of Neurology) where he was responsible for support and development of image analysis for dementia. From 2001 Bill has worked predominantly on non-rigid registration, segmentation and evaluation techniques first within the Computational Imaging Sciences Group at KCL and more recently in the Center for Medical Image Computing at UCL. Since September 2007 he has been at the Centre for Neuroimaging Sciences with an interest in developing novel image analysis techniques to complement and enhance imaging-based studies at IoP. He works within the Biomedical Research Centre for Mental Health (20%) and the King’s Centre of Excellence in Medical Engineering (80%).
activities and interests
I am interested in image analysis applied to structural brain imaging. Application areas include classic structural imaging cross-sectional or serial studies, structural aspects of functional studies, and study-specific methods which combine or build on fundamental image analysis techniques, e.g. atrophy measurement from MRI.
The three corner-stones of structural image analysis are registration, segmentation and classification, and population modelling. I am also interested in evaluation and validation strategies for these techniques.
I am particularly interested in image processing challenges associated with large multi-centre studies.
I run an image processing computing laboratory on imaging pipelines for the Neuroimaging MSc.
Introduction to structural MRI and related image analysis techniques.
Introduction to ethics for imaging.
See full publication details at:
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AC Vernon, S Natesan, WR Crum, JD Cooper, M Modo, SCR Williams and S Kapur, Contrasting effects of haloperidol and lithium on rodent brain structure: an MRI study with post-mortem confirmation, Biological Psychiatry 71(10), pp 855-63, 2012.
E Smith, RP Stroemer, N Gorenkova, M Nakajima, WR Crum, E Tang, L Stevanoto, JD Sinden and M Modo, Implantation site and lesion topology determine efficacy of a human neural stell cell line in a rat model of chronic stroke, Stem Cells 30, pp 785-796, 2012, doi: 10.1002/stem.1024.
MJ Kempton, TSA Underwood, S Brunton, F Stylios, A Schmechtig, U Ettinger, MS Smith, S Lovestone, WR Crum, S Frangou, SCR Williams and A Simmons, A comprehensive testing protocol for neuroanatomical segmentation techniques: Evaluation of a novel lateral ventricle segmentation method, NeuroImage 58(4), pp 1051-1059, 2011.
C Traynor, GJ Barker, WR Crum, SCR Williams and MP Richardson, Segmentation of the thalamus in MRI based on T1 and T2, NeuroImage 56(3), pp 939-950, 2011.
AC Vernon, WR Crum, SM Johansson and MM Modo, Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson’s disease, Public Library of Science One, PLoS ONE 6(2): e17269. doi:10.1371/journal.pone.0017269, 2011. I designed, implemented and applied the image analysis pipeline used in this paper.
WR Crum, Investigations of learning using brain imaging, King’s College Higher Education Research Network Journal 1, 2010.
C Traynor, RA Heckemann, A Hammers, J O’Muircheartaigh, WR Crum, GJ Barker and MP Richardson, Reproducibility of thalamic segmentation based on probabilistic tractography, NeuroImage 52, pp 69-85, 2010.
WR Crum, Spectral Clustering and Label Fusion For 3D Tissue Classification: Sensitivity and Consistency Analysis, Annals of the British Machine Vision Association 6, pp 1-12, 2009.
B Crum, It should be possible to replace animals in research, Nature 457, pp 657, 5 February 2009. (Note: Nature imposed this title on my letter which is somewhat misleading!)
NA Thacker, AF Clark, JL Barron, JR Beveridge, P Courtney, WR Crum, V Ramesh and C Clark, Performance characterization in computer vision: A guide to best practices, Computer Vision and Image Understanding, Volume 109, Issue 3, March 2008, Pages 305-334
K Chen, EM Reiman, GE Alexander, RJ Caselli, R Gerkin, D Bandy, A Domb, D Osborne, N Fox, WR Crum, AM Saunders and J. Hardy, Correlations Between Apolipoprotein E e4 Gene Dose and Whole Brain Atrophy Rates, The American Journal of Psychiatry 164, pp 916-921, 2007.
JH Hipwell, C Tanner, WR Crum, JA Schnabel and DJ Hawkes, A New Validation Method for X-Ray Mammogram Registration Algorithms using a Projection Model of Breast X-Ray Compression, IEEE Transactions in Medical Imaging 26(9), pp 1190-1200, 2007.
WR Crum, O Camara, and DLG Hill, Generalised Overlap Measures for Evaluation and Validation in Medical Image Analysis, IEEE Transactions on Medical Imaging 25(11), pp 1451-1461, 2006. (30 citations)
O Camara, M Schweiger, RI Scahill, WR Crum, B Sneller, JA Schnabel, GR Ridgway, DM Cash, DLG. Hill and NC Fox, Phenomenological model of diffuse global and regional atrophy using Finite-Element methods, IEEE Transactions on Medical Imaging 25(11), pp 1417-1430, 2006. (8 citations)
WR Crum, C Tanner and DJ Hawkes, Multiresolution Anisotropic Fluid Registration: Evaluation in Magnetic Resonance Breast Imaging, Physics in Medicine and Biology 50, pp 5153-5174, 2005. (38 citations)
WR Crum, T Hartkens and DLG Hill, Non-rigid Registration, Theory and Practice, British Journal of Radiology 77: S140-S153, 2004. (43 citations)
WR Crum, Shape and Texture, Chapter 17 in Quantitative MRI of the Brain, editor: Professor Paul Tofts, John Wiley and Sons Ltd, Chichester, UK 2003. http://www.qmri.org/ Winner of 2004 British Medical Association radiology book prize.
WR Crum, LD Griffin, DLG Hill and DJ Hawkes, Zen and the Art of Medical Image Registration: Correspondence, Homology and Quality, NeuroImage 20, pp. 1425-1437, 2003. (75 citations)
WR Crum, RI Scahill and NC Fox, Automated hippocampal segmentation by regional fluid registration of serial MRI: Validation and application in Alzheimer’s disease, NeuroImage 13 (5): pp 847-855 May 2001. (67 citations)
last updated: Thursday, May 09, 2013