Dr Joaquim Radua  MD BStat
PhD student

biography

Dr Radua received his Medical Degree from Universitat Autònoma de Barcelona in 2003. He completed a Psychiatry internship at the Hospital Universitari de Bellvitge (Barcelona) in 2008. He also received a Degree in Statistics from Universitat Autònoma de Barcelona in 2010, being given the prize awarded to the most outstanding graduate.

He is nowadays specialized in neuroimaging research of psychiatric disorders, as well as in the development of new statistical methods and software for neuroimaging research.

activities and interests

Affective neuroscience

Research into mechanisms of emotion and emotional dysregulation in psychiatric disorders, with special focus on the investigation of the neural substrates of emotional processing by means of functional magnetic resonance imaging (fMRI).

Voxel-based meta-analysis

Development of Signed Differential Mapping, a new meta-analytic method for voxel-based neuroimaging modalities such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), voxel-based morphometry (VBM) or diffusion tensor imaging (DTI), as well as its application for investigating a range of neuropsychiatric disorders.

Development of new neuroimaging software

♦   Occ package for R  . This package may be used to estimate positron emission tomography (PET) neuroreceptor occupancies with different fitting methods.

♦   SDM algorithms and graphical interface  . This program may be used to meta-analyse neuroimaging studies using techniques such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), voxel-based morphometry (VBM) or diffusion tensor imaging (DTI). It also includes some utilities to perform simple standard meta-analyses (e.g. for global grey matter volume) as well as to conduct simple arithmetic or statistical operations with 3D images.

publications

2012

♦   The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder.
Radua J, Surguladze SA, Marshall N, Walshe M, Bramon E, Collier DA, Prata D, Murray RM and McDonald C.
Molecular Psychiatry 2012; in Press.

♦   Brain functional abnormality in schizoaffective disorder: a fMRI study.
Madre M, Pomarol-Clotet E, McKenna P, Radua J, Ortiz-Gil J, Panicali F, Goikolea JM, Vieta E, Sarró S, Salvador R and Amann B.
Psychological Medicine 2012; in Press.

♦   Intra- and inter-observer agreement among bronchial endosonographers for the description of intrathoracic lymph nodes.
Garcia-Olive I, Radua J, Serra P, Andreo F, Sanz-Santos J, Monso E, Rosell A, Cases-Viedma E, Fernandez-Villar JA, Nuñez-Delgado M, Garcia-Lujan R, Morera J and Ruiz-Manzano J.
Ultrasound in Medicine and Biology 2012; in Press.

♦   White matter development in adolescence: diffusion tensor imaging and meta-analytic results.
Peters BD, Szeszko PR, Radua J, Ikuta T, Gruner P, Derosse P, Zhang JP, Giorgio A, Qiu D, Tapert SF, Brauer J, Asato MR, Khong PL, James AC, Gallego JA and Malhotra AK.
Schizophrenia Bulletin 2012; in Press.

♦   Meta-analytic methods for neuroimaging data explained  .
Radua J and Mataix-Cols D.
Biology of Mood and Anxiety Disorders 2012; 2:6.

♦   Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis  .
Palaniyappan L, Balain V, Radua J and Liddle PF.
Schizophrenia Research 2012; in Press.

♦   Interaction of catechol O-methyltransferase and serotonin transporter genes modulates effective connectivity in a facial emotion processing circuitry  .
Surguladze SA, Radua J, El-Hage W, Gohier B, Sato J, Kronhaus D, Proitsi P, Powel J and Phillips ML.
Translational Psychiatry 2012; 2:e70.

2011

♦   Genetic modulation of neural response during working memory in healthy individuals: interaction of glucocorticoid receptor and dopaminergic genes  .
El-Hage W, Phillips ML, Radua J, Gohier B, Zelaya FO, Collier DA and Surguladze SA.
Molecular Psychiatry 2011; in Press.

♦   Neuroanatomical maps of psychosis onset: Voxel-wise meta-analysis of antipsychotic-naive VBM studies  .
Fusar-Poli P, Radua J, McGuire P and Stefan B.
Schizophrenia Bulletin 2011; in Press.

♦   Gray matter volume abnormalities in ADHD: Voxel-based meta-analysis exploring the effects of age and stimulant medication  .
Nakao T, Radua J, Rubia K and Mataix-Cols D.
American Journal of Psychiatry 2011; 168:1154-1163.

♦   Deep brain stimulation of the subcallosal cingulate gyrus: further evidence in treatment-resistant major depression  .
Puigdemont D, Perez-Egea R, Portella MJ, Molet J, de Diego-Adelino J, Gironell A, Radua J, Gomez-Anson B, Rodriguez R, Serra M, de Quintana C, Artigas F, Alvarez E and Perez V.
International Journal of Neuropsychopharmacology 2011; 15:121-133.

♦   Restricted maximum likelihood estimation of PET neuroreceptor occupancy in the absence of a reference region  .
Radua J, Bullich S, Lopez N and Catafau AM.
Medical Physics 2011; 38:2558.

♦   A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps  .
Radua J, Mataix-Cols D, Phillips ML, El-Hage W, Kronhaus DM, Cardoner N and Surguladze S.
European Psychiatry 2011; in Press.

♦   Meta-analysis of gray matter abnormalities in autism spectrum disorder  .
Via E, Radua J, Cardoner N, Happe F and Mataix-Cols D.
Archives of General Psychiatry 2011; 68:409-418.

♦   Neuroanatomical abnormalities in schizophrenia: A multimodal voxelwise meta-analysis and meta-regression analysis  .
Bora E, Fornito A, Radua J, Walterfang M, Seal M, Wood SJ, Yucel M, Velakoulis D and Pantelis C.
Schizophrenia Research 2011; 127:46-57.

♦   Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls  .
Radua J, Via E, Catani M and Mataix-Cols D.
Psychological Medicine 2011; 41:1539-1550.

2010

♦   Meta-analytical comparison of voxel-based morphometry studies in obsessive compulsive disorder vs other anxiety disorders  .
Radua J, van den Heuvel OA, Surguladze S and Mataix-Cols D.
Archives of General Psychiatry 2010; 67:701-711.

♦   Heterogeneity of coordinate-based meta-analyses of neuroimaging data: an example from studies in OCD - Authors’ reply  .
Radua J and Mataix-Cols D.
British Journal of Psychiatry 2010; 197:77.

♦   Depression is associated with increased sensitivity to signals of disgust: a functional magnetic resonance imaging study  .
Surguladze SA, El-Hage W, Dalgleish T, Radua J, Gohier B and Phillips ML.
Journal of Psychiatric Research 2010; 44:894-902.

♦   Climatic relationships with specific clinical subtypes of depression  .
Radua J, Pertusa A and Cardoner N.
Psychiatry Research 2010; 175:217-20.

♦   Imaging cortical dopamine D₁ receptors using ¹¹C-NNC112 and ketanserin blockade of the 5-HT_2A receptors  .
Catafau AM, Searle G, Bullich S, Gunn R, Rabiner E, Herance R, Radua J, Farre M and Laruelle M.
Journal of Cerebral Blood Flow and Metabolism 2010; 30:985-93.

♦   Neural response to specific components of fearful faces in healthy and schizophrenic adults  .
Radua J, Phillips ML, Russell T, Lawrence N, Marshall N, Kalidindi S, El-Hage W, McDonald C, Giampietro V, Brammer JM, David AS and Surguladze SA.
NeuroImage 2010; 49:939-946.

2009

♦   Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder  .
Radua J and Mataix-Cols D.
British Journal of Psychiatry 2009; 195:393-402.