Dr Christoph Anacker MSc PhD
Postdoctoral research fellow
|contact this person|
Institute of Psychiatry
The James Black Centre, Institute of Psychiatry, King's College London, 125 Coldharbour Lane, London SE5 9NU
|departments||NIHR BRC for Mental Health|
|also||Centre for the Cellular Basis of Behaviour (CCBB)|
Perinatal Psychiatry & Stress, Psychiatry and Immunology
activities and interests
I am interested in the relationship between stress, depression and adult hippocampal neurogenesis.
Studies have shown that both psychosocial stress and glucocorticoid hormones can reduce the birth of new neurons in the hippocampus of the adult brain. These changes in neurogenesis correlate with the elevation in glucocorticoid levels and the severity of depressive symptoms in animal models. Antidepressants are known to reverse depressive symptoms in humans and rodents and also to normalize stress dependent reduction in hippocampal neurogenesis. Furthermore, research from our laboratory has shown that antidepressants can modulate the function of the glucocorticoid receptor (GR), a ligand-dependent transcription factor, which causes alterations in gene expression upon activation by glucocorticoid hormones.
My research focuses on the effects of glucocorticoid hormones and antidepressants on proliferation, differentiation and neuronal maturation of human hippocampal progenitor cells. I am investigating the role of the GR in these changes in neurogenesis, and I am examining molecular signaling pathways by which antidepressants regulate GR function in stem cells.
Can adult neurogenesis buffer stress responses and depressive behaviour?
Anacker C. and Pariante CM.,
Mol Psychiatry. 2012; Jan; 17(1):9-10
Interleukin-1ß: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis
Zunszain PA., Anacker C., Cattaneo A., Choudhury S., Musaelyan K., Myint AM., Thuret S., Price J., Pariante CM Neuropsychopharmacology. 2011
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J, Pariante CM
Mol Psychiatry. 2011 Jul;16(7):738-50.
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
Anacker C, Zunszain PA, Carvalho LA, Pariante CM.
Psychoneuroendocrinology. 2011 Apr;36(3):415-25. Review.
Glucocorticoids, cytokines and brain abnormalities in depression.
Zunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM.
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):722-9.
Neuronal and vascular protection by the prostaglandin E2 EP4 receptor in a mouse model of cerebral ischemia.
Liang X., Lin L., Woodling N., Wang Q., Anacker C., Pan T., Merchant M., Andreasson KA.,
Journal of Clinical Investigation 2011
Function of prostaglandin E(2) EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy
Taniguchi H, Anacker C, Suarez-Mier GB, Wang Q, Andreasson K.
Neurosci Lett. 2011 Sep 12.
Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants.
Abumaria N, Ribic A, Anacker C, Fuchs E, Flügge G.
Cell Mol Neurobiol. 2008 May;28(3):331-42.
last updated: Friday, June 22, 2012